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MEMS biosensor for parallel and highly sensitive and specific detection of hepatitis

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dc.contributor.coauthorKavaklı, I.H.
dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.kuauthorAlaca, Burhanettin Erdem
dc.contributor.kuauthorErmek, Erhan
dc.contributor.kuauthorTimurdoğan, Erman
dc.contributor.kuauthorÜrey, Hakan
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.date.accessioned2024-11-10T00:01:03Z
dc.date.issued2011
dc.description.abstractA label-free biosensor array that offers highly sensitive, high-dynamic-range and highly specific detection of Hepatitis A antigen is reported. Sensor array consists of Ni cantilevers with surfaces functionalized with Hepatitis A antibody. Cantilevers are self-actuated at resonance using a single electromagnetic drive coil. Detection of resonance frequency is optical and facilitated by diffraction gratings embedded on cantilevers. All antibody-antigen interactions take place within undiluted bovine serum providing a high background noise due to unspecific molecules. A minimum detection limit of less than 0.1 ng/ml target molecule concentration is demonstrated. A high dynamic range is achieved, which is greater than 1000:1 concentration range. The proposed sensor array is shown to be compatible with most of the requirements of a hand-held biosensor including label-free, robust and real-time measurement with well integrated components.
dc.description.indexedbyScopus
dc.description.indexedbyWOS
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipIEEE
dc.description.sponsorshipIEEE Robotics and Automation Society
dc.identifier.doi10.1109/MEMSYS.2011.5734576
dc.identifier.isbn9781-4244-9632-7
dc.identifier.issn1084-6999
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-79953797757
dc.identifier.urihttps://doi.org/10.1109/MEMSYS.2011.5734576
dc.identifier.urihttps://hdl.handle.net/20.500.14288/15902
dc.identifier.wos295841200229
dc.keywordsAntibody-antigen interactions
dc.keywordsAt resonance
dc.keywordsBackground noise
dc.keywordsBovine serum
dc.keywordsConcentration ranges
dc.keywordsDetection limits
dc.keywordsDrive coils
dc.keywordsFunctionalized
dc.keywordsHigh dynamic range
dc.keywordsHighly sensitive
dc.keywordsLabel free
dc.keywordsLabel-free biosensor
dc.keywordsReal time measurements
dc.keywordsResonance frequencies
dc.keywordsSpecific detection
dc.keywordsTarget molecule
dc.keywordsAntibodies
dc.keywordsAntigens
dc.keywordsChemical sensors
dc.keywordsDynamics
dc.keywordsMechanical engineering
dc.keywordsMEMS
dc.keywordsMolecules
dc.keywordsNanocantilevers
dc.keywordsReactive ion etching
dc.keywordsResonance
dc.keywordsSensor arrays
dc.keywordsBiosensors
dc.language.isoeng
dc.publisherIEEE
dc.relation.ispartofProceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS)
dc.subjectElectrical electronics engineering
dc.titleMEMS biosensor for parallel and highly sensitive and specific detection of hepatitis
dc.typeConference Proceeding
dspace.entity.typePublication
local.contributor.kuauthorÜrey, Hakan
local.contributor.kuauthorErmek, Erhan
local.contributor.kuauthorTimurdoğan, Erman
local.contributor.kuauthorAlaca, Burhanettin Erdem
local.publication.orgunit1College of Engineering
local.publication.orgunit1College of Sciences
local.publication.orgunit2Department of Electrical and Electronics Engineering
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relation.isOrgUnitOfPublication.latestForDiscovery21598063-a7c5-420d-91ba-0cc9b2db0ea0
relation.isParentOrgUnitOfPublication8e756b23-2d4a-4ce8-b1b3-62c794a8c164
relation.isParentOrgUnitOfPublicationaf0395b0-7219-4165-a909-7016fa30932d
relation.isParentOrgUnitOfPublication.latestForDiscovery8e756b23-2d4a-4ce8-b1b3-62c794a8c164

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