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Transcriptional regulatory network topology from statistics of DNA binding sites

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We show that the out-degree distribution of the gene regulation network of the budding yeast, Saccharomyces cerevisiae, can be reproduced to high accuracy from the statistics of TF binding sequences. Our observation suggests a particular microscopic mechanism for the observed universal global topology in these networks. The numerical data and analytical solution of our model disagree with a simple power-law for the experimentally obtained degree distribution in the case of yeast.

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Elsevier

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Physics

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Physica A-Statistical Mechanics and Its Applications

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10.1016/j.physa.2007.07.013

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