Publication:
Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology

Placeholder

School / College / Institute

Organizational Unit

Program

KU Authors

Co-Authors

Publication Date

Language

Type

Embargo Status

Journal Title

Journal ISSN

Volume Title

Alternative Title

Abstract

Skeletal muscle is essential in generating mechanical force and regulating energy metabolism and body temperature. Pathologies associated with muscle tissue often lead to impaired physical activity and imbalanced metabolism. Recently, ectodysplasin A2 receptor (EDA2R) signaling has been shown to promote muscle loss and glucose intolerance. Upregulated EDA2R expression in muscle tissue was associated with aging, denervation, cancer cachexia, and muscular dystrophies. Here, we describe the roles of EDA2R signaling in muscle pathophysiology, including muscle atrophy, insulin resistance, and aging-related sarcopenia. We also discuss the EDA2R pathway, which involves EDA-A2 as the ligand and nuclear factor (NF)κB-inducing kinase (NIK) as a downstream mediator, and the therapeutic potential of targeting these proteins in the treatment of muscle wasting and metabolic dysfunction. © 2024 Elsevier Ltd

Source

Publisher

Elsevier Ltd

Subject

Biochemistry and molecular biology, Cell biology, Medicine, research and experimental

Citation

Has Part

Source

Trends in Molecular Medicine

Book Series Title

Edition

DOI

10.1016/j.molmed.2024.02.002

item.page.datauri

Link

Rights

Copyrights Note

Endorsement

Review

Supplemented By

Referenced By

3

Views

0

Downloads

View PlumX Details