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Comparative prognostic performance of CARWL and Naples prognostic score in stage IIIC non-small cell lung cancer treated with definitive chemoradiotherapy

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dc.contributor.coauthorTopkan, E.
dc.contributor.coauthorOzturk, D.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSelek, Uğur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2026-07-19T19:48:31Z
dc.date.issued2026
dc.description.abstractPrognostic stratification remains challenging in patients with stage IIIC non-small cell lung cancer (NSCLC) treated with definitive chemoradiotherapy (CCRT), and the relative performance of host-related prognostic indices in this setting is unclear. The CARWL (C-reactive Protein, Albumin, and Recent Weight Loss) score and the Naples prognostic score (NPS) have each been proposed as prognostic tools, but direct comparisons are lacking. This study compared their prognostic performance. Methods: We retrospectively analyzed 795 patients with stage IIIC NSCLC treated with CCRT between 2010 and 2020. Patients were stratified into three prognostic groups according to CARWL and NPS. Overall survival (OS) was the primary endpoint; progression-free survival (PFS) and locoregional PFS (LRPFS) were secondary endpoints. Survival was assessed using Kaplan–Meier analysis and Cox regression. Results: Both CARWL and NPS significantly stratified OS, PFS, and LRPFS (all p
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionPublished Version
dc.identifier.ScopusPercentile83
dc.identifier.ScopusQuartileQ1
dc.identifier.WoSPercentile90.3
dc.identifier.WoSQuartileQ1
dc.identifier.doi10.3390/medsci14020310
dc.identifier.embargoN/A
dc.identifier.issn2076-3271
dc.identifier.issue2
dc.identifier.pubmed42346849
dc.identifier.scopus2-s2.0-105042855442
dc.identifier.urihttp://doi.org/10.3390/medsci14020310
dc.identifier.urihttps://hdl.handle.net/20.500.14288/33553
dc.identifier.volume14
dc.identifier.wos001804662800001
dc.keywordsCarcinoma
dc.keywordsNon-small-cell lung
dc.keywordsChemoradiotherapy
dc.keywordsPrognosis
dc.keywordsCARWL score
dc.keywordsNaples prognostic score
dc.languageeng
dc.publisherMDPI
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofMedical Sciences
dc.relation.openaccessN/A
dc.rightsN/A
dc.rights.uriN/A
dc.subjectHealth sciences
dc.subjectMedicine
dc.titleComparative prognostic performance of CARWL and Naples prognostic score in stage IIIC non-small cell lung cancer treated with definitive chemoradiotherapy
dc.typeJournal Article
dspace.entity.typePublication
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