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Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)

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dc.contributor.coauthorTowns, Clodagh
dc.contributor.coauthorRicher, Madeleine
dc.contributor.coauthorJasaityte, Simona
dc.contributor.coauthorStafford, Eleanor J.
dc.contributor.coauthorJoubert, Julie
dc.contributor.coauthorAntar, Tarek
dc.contributor.coauthorMartinez-Carrasco, Alejandro
dc.contributor.coauthorMakarious, Mary B.
dc.contributor.coauthorCasey, Bradford
dc.contributor.coauthorVitale, Dan
dc.contributor.coauthorLevine, Kristin
dc.contributor.coauthorLeonard, Hampton
dc.contributor.coauthorPantazis, Caroline B.
dc.contributor.coauthorScreven, Laurel A.
dc.contributor.coauthorHernandez, Dena G.
dc.contributor.coauthorWegel, Claire E.
dc.contributor.coauthorSolle, Justin
dc.contributor.coauthorNalls, Mike A.
dc.contributor.coauthorBlauwendraat, Cornelis
dc.contributor.coauthorSingleton, Andrew B.
dc.contributor.coauthorTan, Manuela M. X.
dc.contributor.coauthorIwaki, Hirotaka
dc.contributor.coauthorMorris, Huw R.
dc.contributor.coauthorGatto, Emilia M.
dc.contributor.coauthorKauffman, Marcelo
dc.contributor.coauthorKhachatryan, Samson
dc.contributor.coauthorTavadyan, Zaruhi
dc.contributor.coauthorShepherd, Claire E.
dc.contributor.coauthorHunter, Julie
dc.contributor.coauthorKumar, Kishore
dc.contributor.coauthorEllis, Melina
dc.contributor.coauthorRentería, Miguel E.
dc.contributor.coauthorKoks, Sulev
dc.contributor.coauthorZimprich, Alexander
dc.contributor.coauthorSchumacher-Schuh, Artur F.
dc.contributor.coauthorRieder, Carlos
dc.contributor.coauthorAwad, Paula Saffie
dc.contributor.coauthorTumas, Vitor
dc.contributor.coauthorCamargos, Sarah
dc.contributor.coauthorFon, Edward A.
dc.contributor.coauthorMonchi, Oury
dc.contributor.coauthorFon, Ted
dc.contributor.coauthorGalleguillos, Benjamin Pizarro
dc.contributor.coauthorMiranda, Marcelo
dc.contributor.coauthorBustamante, Maria Leonor
dc.contributor.coauthorOlguin, Patricio
dc.contributor.coauthorChana, Pedro
dc.contributor.coauthorTang, Beisha
dc.contributor.coauthorShang, Huifang
dc.contributor.coauthorGuo, Jifeng
dc.contributor.coauthorChan, Piu
dc.contributor.coauthorLuo, Wei
dc.contributor.coauthorArboleda, Gonzalo
dc.contributor.coauthorOrozco, Jorge
dc.contributor.coauthordel Rio, Marlene Jimenez
dc.contributor.coauthorHernandez, Alvaro
dc.contributor.coauthorSalama, Mohamed
dc.contributor.coauthorKamel, Walaa A.
dc.contributor.coauthorZewde, Yared Z.
dc.contributor.coauthorBrice, Alexis
dc.contributor.coauthorCorvol, Jean-Christophe
dc.contributor.coauthorWestenberger, Ana
dc.contributor.coauthorIllarionova, Anastasia
dc.contributor.coauthorMollenhauer, Brit
dc.contributor.coauthorKlein, Christine
dc.contributor.coauthorVollstedt, Eva-Juliane
dc.contributor.coauthorHopfner, Franziska
dc.contributor.coauthorHöglinger, Günter
dc.contributor.coauthorMadoev, Harutyun
dc.contributor.coauthorTrinh, Joanne
dc.contributor.coauthorJunker, Johanna
dc.contributor.coauthorLohmann, Katja
dc.contributor.coauthorLange, Lara M.
dc.contributor.coauthorSharma, Manu
dc.contributor.coauthorGroppa, Sergiu
dc.contributor.coauthorGasser, Thomas
dc.contributor.coauthorFang, Zih-Hua
dc.contributor.coauthorAkpalu, Albert
dc.contributor.coauthorXiromerisiou, Georgia
dc.contributor.coauthorHadjigorgiou, Georgios
dc.contributor.coauthorDagklis, Ioannis
dc.contributor.coauthorTarnanas, Ioannis
dc.contributor.coauthorStefanis, Leonidas
dc.contributor.coauthorStamelou, Maria
dc.contributor.coauthorDadiotis, Efthymios
dc.contributor.coauthorMedina, Alex
dc.contributor.coauthorChan, Germaine Hiu-Fai
dc.contributor.coauthorIp, Nancy
dc.contributor.coauthorCheung, Nelson Yuk-Fai
dc.contributor.coauthorChan, Phillip
dc.contributor.coauthorZhou, Xiaopu
dc.contributor.coauthorKishore, Asha
dc.contributor.coauthorKp, Divya
dc.contributor.coauthorPal, Pramod
dc.contributor.coauthorKukkle, Prashanth Lingappa
dc.contributor.coauthorRajan, Roopa
dc.contributor.coauthorBorgohain, Rupam
dc.contributor.coauthorSalari, Mehri
dc.contributor.coauthorQuattrone, Andrea
dc.contributor.coauthorValente, Enza Maria
dc.contributor.coauthorParnetti, Lucilla
dc.contributor.coauthorAvenali, Micol
dc.contributor.coauthorSchirinzi, Tommaso
dc.contributor.coauthorFunayama, Manabu
dc.contributor.coauthorHattori, Nobutaka
dc.contributor.coauthorShiraishi, Tomotaka
dc.contributor.coauthorKarimova, Altynay
dc.contributor.coauthorKaishibayeva, Gulnaz
dc.contributor.coauthorShambetova, Cholpon
dc.contributor.coauthorKrüger, Rejko
dc.contributor.coauthorTan, Ai Huey
dc.contributor.coauthorAhmad-Annuar, Azlina
dc.contributor.coauthorNorlinah, Mohamed Ibrahim
dc.contributor.coauthorMurad, Nor Azian Abdul
dc.contributor.coauthorAzmin, Shahrul
dc.contributor.coauthorLim, Shen-Yang
dc.contributor.coauthorMohamed, Wael
dc.contributor.coauthorTay, Yi Wen
dc.contributor.coauthorMartinez-Ramirez, Daniel
dc.contributor.coauthorRodriguez-Violante, Mayela
dc.contributor.coauthorReyes-Pérez, Paula
dc.contributor.coauthorTserensodnom, Bayasgalan
dc.contributor.coauthorOjha, Rajeev
dc.contributor.coauthorAnderson, Tim J.
dc.contributor.coauthorPitcher, Toni L.
dc.contributor.coauthorSanyaolu, Arinola
dc.contributor.coauthorOkubadejo, Njideka
dc.contributor.coauthorOjo, Oluwadamilola
dc.contributor.coauthorAasly, Jan O.
dc.contributor.coauthorPihlstrøm, Lasse
dc.contributor.coauthorTan, Manuela
dc.contributor.coauthorUr-Rehman, Shoaib
dc.contributor.coauthorCornejo-Olivas, Mario
dc.contributor.coauthorDoquenia, Maria Leila
dc.contributor.coauthorRosales, Raymond
dc.contributor.coauthorVinuela, Angel
dc.contributor.coauthorIakovenko, Elena
dc.contributor.coauthorMubarak, Bashayer Al
dc.contributor.coauthorUmair, Muhammad
dc.contributor.coauthorTan, Eng-King
dc.contributor.coauthorFoo, Jia Nee
dc.contributor.coauthorAmod, Ferzana
dc.contributor.coauthorCarr, Jonathan
dc.contributor.coauthorBardien, Soraya
dc.contributor.coauthorJeon, Beomseok
dc.contributor.coauthorKim, Yun Joong
dc.contributor.coauthorCubo, Esther
dc.contributor.coauthorAlvarez, Ignacio
dc.contributor.coauthorHoenicka, Janet
dc.contributor.coauthorBeyer, Katrin
dc.contributor.coauthorPeriñan, Maria Teresa
dc.contributor.coauthorPastor, Pau
dc.contributor.coauthorEl-Sadig, Sarah
dc.contributor.coauthorZweier, Christiane
dc.contributor.coauthorKrack, Paul
dc.contributor.coauthorLin, Chin-Hsien
dc.contributor.coauthorWu, Hsiu-Chuan
dc.contributor.coauthorKung, Pin-Jui
dc.contributor.coauthorWu, Ruey-Meei
dc.contributor.coauthorWu, Yihru
dc.contributor.coauthorAmouri, Rim
dc.contributor.coauthorSassi, Samia Ben
dc.contributor.coauthorGenc, Gencer
dc.contributor.coauthorNoyce, Alastair
dc.contributor.coauthorSchrag, Anette
dc.contributor.coauthorSchapira, Anthony
dc.contributor.coauthorCarroll, Camille
dc.contributor.coauthorBale, Claire
dc.contributor.coauthorGrosset, Donald
dc.contributor.coauthorHoulden, Henry
dc.contributor.coauthorHardy, John
dc.contributor.coauthorMok, Kin Ying
dc.contributor.coauthorRizig, Mie
dc.contributor.coauthorWood, Nicholas
dc.contributor.coauthorWilliams, Nigel
dc.contributor.coauthorOkunoye, Olaitan
dc.contributor.coauthorLewis, Patrick Alfryn
dc.contributor.coauthorKaiyrzhanov, Rauan
dc.contributor.coauthorWeil, Rimona
dc.contributor.coauthorLove, Seth
dc.contributor.coauthorStott, Simon
dc.contributor.coauthorJasaitye, Simona
dc.contributor.coauthorDey, Sumit
dc.contributor.coauthorObese, Vida
dc.contributor.coauthorEspay, Alberto
dc.contributor.coauthorO’Grady, Alyssa
dc.contributor.coauthorSobering, Andrew K.
dc.contributor.coauthorSiddiqi, Bernadette
dc.contributor.coauthorFiske, Brian
dc.contributor.coauthorJonas, Cabell
dc.contributor.coauthorCruchaga, Carlos
dc.contributor.coauthorComart, Charisse
dc.contributor.coauthorWegel, Claire
dc.contributor.coauthorHall, Deborah
dc.contributor.coauthorHernandez, Dena
dc.contributor.coauthorShiamim, Ejaz
dc.contributor.coauthorRiley, Ekemini
dc.contributor.coauthorFaghri, Faraz
dc.contributor.coauthorSerrano, Geidy E.
dc.contributor.coauthorChen, Honglei
dc.contributor.coauthorMata, Ignacio F.
dc.contributor.coauthorSarmiento, Ignacio Juan Keller
dc.contributor.coauthorWilliamson, Jared
dc.contributor.coauthorKim, Jonggeol Jeff
dc.contributor.coauthorJankovic, Joseph
dc.contributor.coauthorShulman, Joshua
dc.contributor.coauthorSolle, Justin C.
dc.contributor.coauthorMurphy, Kaileigh
dc.contributor.coauthorNuytemans, Karen
dc.contributor.coauthorKieburtz, Karl
dc.contributor.coauthorMarkopoulou, Katerina
dc.contributor.coauthorMarek, Kenneth
dc.contributor.coauthorLevine, Kristin S.
dc.contributor.coauthorChahine, Lana M.
dc.contributor.coauthorIbanez, Laura
dc.contributor.coauthorScreven, Laurel
dc.contributor.coauthorRuffrage, Lauren
dc.contributor.coauthorShulman, Lisa
dc.contributor.coauthorMarsili, Luca
dc.contributor.coauthorKuhl, Maggie
dc.contributor.coauthorDean, Marissa
dc.contributor.coauthorKoretsky, Mathew
dc.contributor.coauthorPuckelwartz, Megan J.
dc.contributor.coauthorInca-Martinez, Miguel
dc.contributor.coauthorLouie, Naomi
dc.contributor.coauthorMencacci, Niccolò Emanuele
dc.contributor.coauthorAlbin, Roger
dc.contributor.coauthorAlcalay, Roy
dc.contributor.coauthorWalker, Ruth
dc.contributor.coauthorBandres-Ciga, Sara
dc.contributor.coauthorChowdhury, Sohini
dc.contributor.coauthorDumanis, Sonya
dc.contributor.coauthorLubbe, Steven
dc.contributor.coauthorXie, Tao
dc.contributor.coauthorForoud, Tatiana
dc.contributor.coauthorBeach, Thomas
dc.contributor.coauthorSherer, Todd
dc.contributor.coauthorSong, Yeajin
dc.contributor.coauthorNguyen, Duan
dc.contributor.coauthorNguyen, Toan
dc.contributor.coauthorAtadzhanov, Masharip
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorÇakmak, Özgür Öztop
dc.contributor.kuauthorBaşak, Ayşe Nazlı
dc.contributor.kuauthorErtan, Fatoş Sibel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:29:00Z
dc.date.issued2023
dc.description.abstractThe Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessAll Open Access; Gold Open Access
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipFunding text 1: This research is supported by the Aligning Science Across Parkinson’s Initiative, the Intramural Research Program, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949, and the Michael J. Fox Foundation for Parkinson’s Research. Data used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org . ; Funding text 2: A.B.S. and C.B. are supported by the Intramural Research Program of the National Institute on Aging and have received grant support from the Michael J. Fox Foundation for Parkinson’s Research and the Aligning Science Across Parkinson’s Initiative. A.B.S. has received royalty payments related to a diagnostic for stroke. A.B.S. is an editor for npj Parkinson’s Disease. A.B.S. was not involved in the journal’s review of, or decisions related to, this manuscript. H.L., H.I., D.V., K.L., and M.A.N. are consultants employed by Data Tecnica International. Data Tecnica is engaged in a consulting agreement with the US National Institutes of Health. H.R.M. is employed by UCL. In the last 24 months, he reports paid consultancy from Biogen, Biohaven, Lundbeck; lecture fees/honoraria from Wellcome Trust, Movement Disorders Society; Research Grants from Parkinson’s UK, Cure Parkinson’s Trust, PSP Association, CBD Solutions, Drake Foundation, Medical Research Council, Michael J. Fox Foundation. H.R.M. is also a co-applicant on a patent application related to C9ORF72—Method for diagnosing a neurodegenerative disease (PCT/GB2012/052140). BC and JS are employed by the Michael J. Fox Foundation for Parkinson’s Research. All other authors declare no financial or non-financial competing interests.
dc.description.volume9
dc.identifier.doi10.1038/s41531-023-00533-w
dc.identifier.issn2373-8057
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85170643330
dc.identifier.urihttps://doi.org/10.1038/s41531-023-00533-w
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25808
dc.identifier.wos1188490300001
dc.keywordsCerebrospinal fluid
dc.keywordsClinical outcome
dc.keywordsClinical study
dc.keywordsData analysis
dc.keywordsDemography
dc.keywordsDiffuse Lewy body disease
dc.language.isoeng
dc.publisherNature Research
dc.relation.grantnoAligning Science Across Parkinson’s Initiative; Parkinson’s UK, Cure Parkinson’s Trust; National Institutes of Health, NIH; U.S. Department of Health and Human Services, HHS, (ZO1 AG000949); National Institute on Aging, NIA; Michael J. Fox Foundation for Parkinson's Research, MJFF; International Parkinson and Movement Disorder Society, MDS; Wellcome Trust, WT; PSP Association, PSPA; Aligning Science Across Parkinson's, ASAP; PCB Solutions; Medical Research Council, MRC; Drake Foundation
dc.relation.ispartofNPJ Parkinson's Disease
dc.subjectNeurosciences
dc.titleDefining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorBaşak, Ayşe Nazlı
local.contributor.kuauthorÇakmak, Özgür Öztop
local.contributor.kuauthorErtan, Fatoş Sibel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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