Publication: Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2)
dc.contributor.coauthor | Towns, Clodagh | |
dc.contributor.coauthor | Richer, Madeleine | |
dc.contributor.coauthor | Jasaityte, Simona | |
dc.contributor.coauthor | Stafford, Eleanor J. | |
dc.contributor.coauthor | Joubert, Julie | |
dc.contributor.coauthor | Antar, Tarek | |
dc.contributor.coauthor | Martinez-Carrasco, Alejandro | |
dc.contributor.coauthor | Makarious, Mary B. | |
dc.contributor.coauthor | Casey, Bradford | |
dc.contributor.coauthor | Vitale, Dan | |
dc.contributor.coauthor | Levine, Kristin | |
dc.contributor.coauthor | Leonard, Hampton | |
dc.contributor.coauthor | Pantazis, Caroline B. | |
dc.contributor.coauthor | Screven, Laurel A. | |
dc.contributor.coauthor | Hernandez, Dena G. | |
dc.contributor.coauthor | Wegel, Claire E. | |
dc.contributor.coauthor | Solle, Justin | |
dc.contributor.coauthor | Nalls, Mike A. | |
dc.contributor.coauthor | Blauwendraat, Cornelis | |
dc.contributor.coauthor | Singleton, Andrew B. | |
dc.contributor.coauthor | Tan, Manuela M. X. | |
dc.contributor.coauthor | Iwaki, Hirotaka | |
dc.contributor.coauthor | Morris, Huw R. | |
dc.contributor.coauthor | Gatto, Emilia M. | |
dc.contributor.coauthor | Kauffman, Marcelo | |
dc.contributor.coauthor | Khachatryan, Samson | |
dc.contributor.coauthor | Tavadyan, Zaruhi | |
dc.contributor.coauthor | Shepherd, Claire E. | |
dc.contributor.coauthor | Hunter, Julie | |
dc.contributor.coauthor | Kumar, Kishore | |
dc.contributor.coauthor | Ellis, Melina | |
dc.contributor.coauthor | Rentería, Miguel E. | |
dc.contributor.coauthor | Koks, Sulev | |
dc.contributor.coauthor | Zimprich, Alexander | |
dc.contributor.coauthor | Schumacher-Schuh, Artur F. | |
dc.contributor.coauthor | Rieder, Carlos | |
dc.contributor.coauthor | Awad, Paula Saffie | |
dc.contributor.coauthor | Tumas, Vitor | |
dc.contributor.coauthor | Camargos, Sarah | |
dc.contributor.coauthor | Fon, Edward A. | |
dc.contributor.coauthor | Monchi, Oury | |
dc.contributor.coauthor | Fon, Ted | |
dc.contributor.coauthor | Galleguillos, Benjamin Pizarro | |
dc.contributor.coauthor | Miranda, Marcelo | |
dc.contributor.coauthor | Bustamante, Maria Leonor | |
dc.contributor.coauthor | Olguin, Patricio | |
dc.contributor.coauthor | Chana, Pedro | |
dc.contributor.coauthor | Tang, Beisha | |
dc.contributor.coauthor | Shang, Huifang | |
dc.contributor.coauthor | Guo, Jifeng | |
dc.contributor.coauthor | Chan, Piu | |
dc.contributor.coauthor | Luo, Wei | |
dc.contributor.coauthor | Arboleda, Gonzalo | |
dc.contributor.coauthor | Orozco, Jorge | |
dc.contributor.coauthor | del Rio, Marlene Jimenez | |
dc.contributor.coauthor | Hernandez, Alvaro | |
dc.contributor.coauthor | Salama, Mohamed | |
dc.contributor.coauthor | Kamel, Walaa A. | |
dc.contributor.coauthor | Zewde, Yared Z. | |
dc.contributor.coauthor | Brice, Alexis | |
dc.contributor.coauthor | Corvol, Jean-Christophe | |
dc.contributor.coauthor | Westenberger, Ana | |
dc.contributor.coauthor | Illarionova, Anastasia | |
dc.contributor.coauthor | Mollenhauer, Brit | |
dc.contributor.coauthor | Klein, Christine | |
dc.contributor.coauthor | Vollstedt, Eva-Juliane | |
dc.contributor.coauthor | Hopfner, Franziska | |
dc.contributor.coauthor | Höglinger, Günter | |
dc.contributor.coauthor | Madoev, Harutyun | |
dc.contributor.coauthor | Trinh, Joanne | |
dc.contributor.coauthor | Junker, Johanna | |
dc.contributor.coauthor | Lohmann, Katja | |
dc.contributor.coauthor | Lange, Lara M. | |
dc.contributor.coauthor | Sharma, Manu | |
dc.contributor.coauthor | Groppa, Sergiu | |
dc.contributor.coauthor | Gasser, Thomas | |
dc.contributor.coauthor | Fang, Zih-Hua | |
dc.contributor.coauthor | Akpalu, Albert | |
dc.contributor.coauthor | Xiromerisiou, Georgia | |
dc.contributor.coauthor | Hadjigorgiou, Georgios | |
dc.contributor.coauthor | Dagklis, Ioannis | |
dc.contributor.coauthor | Tarnanas, Ioannis | |
dc.contributor.coauthor | Stefanis, Leonidas | |
dc.contributor.coauthor | Stamelou, Maria | |
dc.contributor.coauthor | Dadiotis, Efthymios | |
dc.contributor.coauthor | Medina, Alex | |
dc.contributor.coauthor | Chan, Germaine Hiu-Fai | |
dc.contributor.coauthor | Ip, Nancy | |
dc.contributor.coauthor | Cheung, Nelson Yuk-Fai | |
dc.contributor.coauthor | Chan, Phillip | |
dc.contributor.coauthor | Zhou, Xiaopu | |
dc.contributor.coauthor | Kishore, Asha | |
dc.contributor.coauthor | Kp, Divya | |
dc.contributor.coauthor | Pal, Pramod | |
dc.contributor.coauthor | Kukkle, Prashanth Lingappa | |
dc.contributor.coauthor | Rajan, Roopa | |
dc.contributor.coauthor | Borgohain, Rupam | |
dc.contributor.coauthor | Salari, Mehri | |
dc.contributor.coauthor | Quattrone, Andrea | |
dc.contributor.coauthor | Valente, Enza Maria | |
dc.contributor.coauthor | Parnetti, Lucilla | |
dc.contributor.coauthor | Avenali, Micol | |
dc.contributor.coauthor | Schirinzi, Tommaso | |
dc.contributor.coauthor | Funayama, Manabu | |
dc.contributor.coauthor | Hattori, Nobutaka | |
dc.contributor.coauthor | Shiraishi, Tomotaka | |
dc.contributor.coauthor | Karimova, Altynay | |
dc.contributor.coauthor | Kaishibayeva, Gulnaz | |
dc.contributor.coauthor | Shambetova, Cholpon | |
dc.contributor.coauthor | Krüger, Rejko | |
dc.contributor.coauthor | Tan, Ai Huey | |
dc.contributor.coauthor | Ahmad-Annuar, Azlina | |
dc.contributor.coauthor | Norlinah, Mohamed Ibrahim | |
dc.contributor.coauthor | Murad, Nor Azian Abdul | |
dc.contributor.coauthor | Azmin, Shahrul | |
dc.contributor.coauthor | Lim, Shen-Yang | |
dc.contributor.coauthor | Mohamed, Wael | |
dc.contributor.coauthor | Tay, Yi Wen | |
dc.contributor.coauthor | Martinez-Ramirez, Daniel | |
dc.contributor.coauthor | Rodriguez-Violante, Mayela | |
dc.contributor.coauthor | Reyes-Pérez, Paula | |
dc.contributor.coauthor | Tserensodnom, Bayasgalan | |
dc.contributor.coauthor | Ojha, Rajeev | |
dc.contributor.coauthor | Anderson, Tim J. | |
dc.contributor.coauthor | Pitcher, Toni L. | |
dc.contributor.coauthor | Sanyaolu, Arinola | |
dc.contributor.coauthor | Okubadejo, Njideka | |
dc.contributor.coauthor | Ojo, Oluwadamilola | |
dc.contributor.coauthor | Aasly, Jan O. | |
dc.contributor.coauthor | Pihlstrøm, Lasse | |
dc.contributor.coauthor | Tan, Manuela | |
dc.contributor.coauthor | Ur-Rehman, Shoaib | |
dc.contributor.coauthor | Cornejo-Olivas, Mario | |
dc.contributor.coauthor | Doquenia, Maria Leila | |
dc.contributor.coauthor | Rosales, Raymond | |
dc.contributor.coauthor | Vinuela, Angel | |
dc.contributor.coauthor | Iakovenko, Elena | |
dc.contributor.coauthor | Mubarak, Bashayer Al | |
dc.contributor.coauthor | Umair, Muhammad | |
dc.contributor.coauthor | Tan, Eng-King | |
dc.contributor.coauthor | Foo, Jia Nee | |
dc.contributor.coauthor | Amod, Ferzana | |
dc.contributor.coauthor | Carr, Jonathan | |
dc.contributor.coauthor | Bardien, Soraya | |
dc.contributor.coauthor | Jeon, Beomseok | |
dc.contributor.coauthor | Kim, Yun Joong | |
dc.contributor.coauthor | Cubo, Esther | |
dc.contributor.coauthor | Alvarez, Ignacio | |
dc.contributor.coauthor | Hoenicka, Janet | |
dc.contributor.coauthor | Beyer, Katrin | |
dc.contributor.coauthor | Periñan, Maria Teresa | |
dc.contributor.coauthor | Pastor, Pau | |
dc.contributor.coauthor | El-Sadig, Sarah | |
dc.contributor.coauthor | Zweier, Christiane | |
dc.contributor.coauthor | Krack, Paul | |
dc.contributor.coauthor | Lin, Chin-Hsien | |
dc.contributor.coauthor | Wu, Hsiu-Chuan | |
dc.contributor.coauthor | Kung, Pin-Jui | |
dc.contributor.coauthor | Wu, Ruey-Meei | |
dc.contributor.coauthor | Wu, Yihru | |
dc.contributor.coauthor | Amouri, Rim | |
dc.contributor.coauthor | Sassi, Samia Ben | |
dc.contributor.coauthor | Genc, Gencer | |
dc.contributor.coauthor | Noyce, Alastair | |
dc.contributor.coauthor | Schrag, Anette | |
dc.contributor.coauthor | Schapira, Anthony | |
dc.contributor.coauthor | Carroll, Camille | |
dc.contributor.coauthor | Bale, Claire | |
dc.contributor.coauthor | Grosset, Donald | |
dc.contributor.coauthor | Houlden, Henry | |
dc.contributor.coauthor | Hardy, John | |
dc.contributor.coauthor | Mok, Kin Ying | |
dc.contributor.coauthor | Rizig, Mie | |
dc.contributor.coauthor | Wood, Nicholas | |
dc.contributor.coauthor | Williams, Nigel | |
dc.contributor.coauthor | Okunoye, Olaitan | |
dc.contributor.coauthor | Lewis, Patrick Alfryn | |
dc.contributor.coauthor | Kaiyrzhanov, Rauan | |
dc.contributor.coauthor | Weil, Rimona | |
dc.contributor.coauthor | Love, Seth | |
dc.contributor.coauthor | Stott, Simon | |
dc.contributor.coauthor | Jasaitye, Simona | |
dc.contributor.coauthor | Dey, Sumit | |
dc.contributor.coauthor | Obese, Vida | |
dc.contributor.coauthor | Espay, Alberto | |
dc.contributor.coauthor | O’Grady, Alyssa | |
dc.contributor.coauthor | Sobering, Andrew K. | |
dc.contributor.coauthor | Siddiqi, Bernadette | |
dc.contributor.coauthor | Fiske, Brian | |
dc.contributor.coauthor | Jonas, Cabell | |
dc.contributor.coauthor | Cruchaga, Carlos | |
dc.contributor.coauthor | Comart, Charisse | |
dc.contributor.coauthor | Wegel, Claire | |
dc.contributor.coauthor | Hall, Deborah | |
dc.contributor.coauthor | Hernandez, Dena | |
dc.contributor.coauthor | Shiamim, Ejaz | |
dc.contributor.coauthor | Riley, Ekemini | |
dc.contributor.coauthor | Faghri, Faraz | |
dc.contributor.coauthor | Serrano, Geidy E. | |
dc.contributor.coauthor | Chen, Honglei | |
dc.contributor.coauthor | Mata, Ignacio F. | |
dc.contributor.coauthor | Sarmiento, Ignacio Juan Keller | |
dc.contributor.coauthor | Williamson, Jared | |
dc.contributor.coauthor | Kim, Jonggeol Jeff | |
dc.contributor.coauthor | Jankovic, Joseph | |
dc.contributor.coauthor | Shulman, Joshua | |
dc.contributor.coauthor | Solle, Justin C. | |
dc.contributor.coauthor | Murphy, Kaileigh | |
dc.contributor.coauthor | Nuytemans, Karen | |
dc.contributor.coauthor | Kieburtz, Karl | |
dc.contributor.coauthor | Markopoulou, Katerina | |
dc.contributor.coauthor | Marek, Kenneth | |
dc.contributor.coauthor | Levine, Kristin S. | |
dc.contributor.coauthor | Chahine, Lana M. | |
dc.contributor.coauthor | Ibanez, Laura | |
dc.contributor.coauthor | Screven, Laurel | |
dc.contributor.coauthor | Ruffrage, Lauren | |
dc.contributor.coauthor | Shulman, Lisa | |
dc.contributor.coauthor | Marsili, Luca | |
dc.contributor.coauthor | Kuhl, Maggie | |
dc.contributor.coauthor | Dean, Marissa | |
dc.contributor.coauthor | Koretsky, Mathew | |
dc.contributor.coauthor | Puckelwartz, Megan J. | |
dc.contributor.coauthor | Inca-Martinez, Miguel | |
dc.contributor.coauthor | Louie, Naomi | |
dc.contributor.coauthor | Mencacci, Niccolò Emanuele | |
dc.contributor.coauthor | Albin, Roger | |
dc.contributor.coauthor | Alcalay, Roy | |
dc.contributor.coauthor | Walker, Ruth | |
dc.contributor.coauthor | Bandres-Ciga, Sara | |
dc.contributor.coauthor | Chowdhury, Sohini | |
dc.contributor.coauthor | Dumanis, Sonya | |
dc.contributor.coauthor | Lubbe, Steven | |
dc.contributor.coauthor | Xie, Tao | |
dc.contributor.coauthor | Foroud, Tatiana | |
dc.contributor.coauthor | Beach, Thomas | |
dc.contributor.coauthor | Sherer, Todd | |
dc.contributor.coauthor | Song, Yeajin | |
dc.contributor.coauthor | Nguyen, Duan | |
dc.contributor.coauthor | Nguyen, Toan | |
dc.contributor.coauthor | Atadzhanov, Masharip | |
dc.contributor.department | School of Medicine | |
dc.contributor.kuauthor | Çakmak, Özgür Öztop | |
dc.contributor.kuauthor | Başak, Ayşe Nazlı | |
dc.contributor.kuauthor | Ertan, Fatoş Sibel | |
dc.contributor.schoolcollegeinstitute | SCHOOL OF MEDICINE | |
dc.date.accessioned | 2025-01-19T10:29:00Z | |
dc.date.issued | 2023 | |
dc.description.abstract | The Global Parkinson’s Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our understanding of the genetic architecture of PD. This report details the workflow for cohort integration into the complex arm of GP2, and together with our outline of the monogenic hub in a companion paper, provides a generalizable blueprint for establishing large scale collaborative research consortia. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 1 | |
dc.description.openaccess | All Open Access; Gold Open Access | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | Funding text 1: This research is supported by the Aligning Science Across Parkinson’s Initiative, the Intramural Research Program, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, project ZO1 AG000949, and the Michael J. Fox Foundation for Parkinson’s Research. Data used in the preparation of this article were obtained from Global Parkinson’s Genetics Program (GP2). GP2 is funded by the Aligning Science Across Parkinson’s (ASAP) initiative and implemented by The Michael J. Fox Foundation for Parkinson’s Research ( https://gp2.org ). For a complete list of GP2 members see https://gp2.org . ; Funding text 2: A.B.S. and C.B. are supported by the Intramural Research Program of the National Institute on Aging and have received grant support from the Michael J. Fox Foundation for Parkinson’s Research and the Aligning Science Across Parkinson’s Initiative. A.B.S. has received royalty payments related to a diagnostic for stroke. A.B.S. is an editor for npj Parkinson’s Disease. A.B.S. was not involved in the journal’s review of, or decisions related to, this manuscript. H.L., H.I., D.V., K.L., and M.A.N. are consultants employed by Data Tecnica International. Data Tecnica is engaged in a consulting agreement with the US National Institutes of Health. H.R.M. is employed by UCL. In the last 24 months, he reports paid consultancy from Biogen, Biohaven, Lundbeck; lecture fees/honoraria from Wellcome Trust, Movement Disorders Society; Research Grants from Parkinson’s UK, Cure Parkinson’s Trust, PSP Association, CBD Solutions, Drake Foundation, Medical Research Council, Michael J. Fox Foundation. H.R.M. is also a co-applicant on a patent application related to C9ORF72—Method for diagnosing a neurodegenerative disease (PCT/GB2012/052140). BC and JS are employed by the Michael J. Fox Foundation for Parkinson’s Research. All other authors declare no financial or non-financial competing interests. | |
dc.description.volume | 9 | |
dc.identifier.doi | 10.1038/s41531-023-00533-w | |
dc.identifier.issn | 2373-8057 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85170643330 | |
dc.identifier.uri | https://doi.org/10.1038/s41531-023-00533-w | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/25808 | |
dc.identifier.wos | 1188490300001 | |
dc.keywords | Cerebrospinal fluid | |
dc.keywords | Clinical outcome | |
dc.keywords | Clinical study | |
dc.keywords | Data analysis | |
dc.keywords | Demography | |
dc.keywords | Diffuse Lewy body disease | |
dc.language.iso | eng | |
dc.publisher | Nature Research | |
dc.relation.grantno | Aligning Science Across Parkinson’s Initiative; Parkinson’s UK, Cure Parkinson’s Trust; National Institutes of Health, NIH; U.S. Department of Health and Human Services, HHS, (ZO1 AG000949); National Institute on Aging, NIA; Michael J. Fox Foundation for Parkinson's Research, MJFF; International Parkinson and Movement Disorder Society, MDS; Wellcome Trust, WT; PSP Association, PSPA; Aligning Science Across Parkinson's, ASAP; PCB Solutions; Medical Research Council, MRC; Drake Foundation | |
dc.relation.ispartof | NPJ Parkinson's Disease | |
dc.subject | Neurosciences | |
dc.title | Defining the causes of sporadic Parkinson’s disease in the global Parkinson’s genetics program (GP2) | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Başak, Ayşe Nazlı | |
local.contributor.kuauthor | Çakmak, Özgür Öztop | |
local.contributor.kuauthor | Ertan, Fatoş Sibel | |
local.publication.orgunit1 | SCHOOL OF MEDICINE | |
local.publication.orgunit2 | School of Medicine | |
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