Publication:
Technology roadmap of micro/nanorobots

dc.contributor.coauthorJu, Xiaohui
dc.contributor.coauthorChen, Chuanrui
dc.contributor.coauthorOral, Cagatay M.
dc.contributor.coauthorSevim, Semih
dc.contributor.coauthorGolestanian, Ramin
dc.contributor.coauthorSun, Mengmeng
dc.contributor.coauthorBouzari, Negin
dc.contributor.coauthorLin, Xiankun
dc.contributor.coauthorUrso, Mario
dc.contributor.coauthorNam, Jong Seok
dc.contributor.coauthorCho, Yujang
dc.contributor.coauthorPeng, Xia
dc.contributor.coauthorLanders, Fabian C.
dc.contributor.coauthorYang, Shihao
dc.contributor.coauthorAdibi, Azin
dc.contributor.coauthorTaz, Nahid
dc.contributor.coauthorWittkowski, Raphael
dc.contributor.coauthorAhmed, Daniel
dc.contributor.coauthorWang, Wei
dc.contributor.coauthorMagdanz, Veronika
dc.contributor.coauthorMedina-Sanchez, Mariana
dc.contributor.coauthorGuix, Maria
dc.contributor.coauthorBari, Naimat
dc.contributor.coauthorBehkam, Bahareh
dc.contributor.coauthorKapral, Raymond
dc.contributor.coauthorHuang, Yaxin
dc.contributor.coauthorTang, Jinyao
dc.contributor.coauthorWang, Ben
dc.contributor.coauthorMorozov, Konstantin
dc.contributor.coauthorLeshansky, Alexander
dc.contributor.coauthorAbbasi, Sarmad Ahmad
dc.contributor.coauthorChoi, Hongsoo
dc.contributor.coauthorGhosh, Subhadip
dc.contributor.coauthorFernandes, Barbara Borges
dc.contributor.coauthorBattaglia, Giuseppe
dc.contributor.coauthorFischer, Peer
dc.contributor.coauthorGhosh, Ambarish
dc.contributor.coauthorSanchez, Beatriz Jurado
dc.contributor.coauthorEscarpa, Alberto
dc.contributor.coauthorMartinet, Quentin
dc.contributor.coauthorPalacci, Jeremie
dc.contributor.coauthorLauga, Eric
dc.contributor.coauthorMoran, Jeffrey
dc.contributor.coauthorRamos-Docampo, Miguel A.
dc.contributor.coauthorStadler, Brigitte
dc.contributor.coauthorRestrepo, Ramon Santiago Herrera
dc.contributor.coauthorYossifon, Gilad
dc.contributor.coauthorNicholas, James D.
dc.contributor.coauthorIgnes-Mullol, Jordi
dc.contributor.coauthorPuigmarti-Luis, Josep
dc.contributor.coauthorLiu, Yutong
dc.contributor.coauthorZarzar, Lauren D.
dc.contributor.coauthorShields, C. Wyatt
dc.contributor.coauthorLi, Longqiu
dc.contributor.coauthorLi, Shanshan
dc.contributor.coauthorMa, Xing
dc.contributor.coauthorGracias, David H.
dc.contributor.coauthorVelev, Orlin
dc.contributor.coauthorSanchez, Samuel
dc.contributor.coauthorEsplandiu, Maria Jose
dc.contributor.coauthorSimmchen, Juliane
dc.contributor.coauthorLobosco, Antonio
dc.contributor.coauthorMisra, Sarthak
dc.contributor.coauthorWu, Zhiguang
dc.contributor.coauthorLi, Jinxing
dc.contributor.coauthorKuhn, Alexander
dc.contributor.coauthorNourhani, Amir
dc.contributor.coauthorMaric, Tijana
dc.contributor.coauthorXiong, Ze
dc.contributor.coauthorAghakhani, Amirreza
dc.contributor.coauthorMei, Yongfeng
dc.contributor.coauthorTu, Yingfeng
dc.contributor.coauthorPeng, Fei
dc.contributor.coauthorDiller, Eric
dc.contributor.coauthorSakar, Mahmut Selman
dc.contributor.coauthorSen, Ayusman
dc.contributor.coauthorLaw, Junhui
dc.contributor.coauthorSun, Yu
dc.contributor.coauthorPena-Francesch, Abdon
dc.contributor.coauthorVilla, Katherine
dc.contributor.coauthorLi, Huaizhi
dc.contributor.coauthorFan, Donglei Emma
dc.contributor.coauthorLiang, Kang
dc.contributor.coauthorHuang, Tony Jun
dc.contributor.coauthorChen, Xiang-Zhong
dc.contributor.coauthorTang, Songsong
dc.contributor.coauthorZhang, Xueji
dc.contributor.coauthorCui, Jizhai
dc.contributor.coauthorWang, Hong
dc.contributor.coauthorGao, Wei
dc.contributor.coauthorBandari, Vineeth Kumar
dc.contributor.coauthorSchmidt, Oliver G.
dc.contributor.coauthorWu, Xianghua
dc.contributor.coauthorGuan, Jianguo
dc.contributor.coauthorSitti, Metin
dc.contributor.coauthorNelson, Bradley J.
dc.contributor.coauthorPane, Salvador
dc.contributor.coauthorZhang, Li
dc.contributor.coauthorShahsavan, Hamed
dc.contributor.coauthorHe, Qiang
dc.contributor.coauthorKim, Il-Doo
dc.contributor.coauthorWang, Joseph
dc.contributor.coauthorPumera, Martin
dc.contributor.departmentSchool of Medicine
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.kuauthorSitti, Metin
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2025-09-10T04:59:59Z
dc.date.available2025-09-09
dc.date.issued2025
dc.description.abstractInspired by Richard Feynman's 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to scaling up production, commercialization, and regulatory frameworks that are crucial for transitioning from research to practical applications. We also emphasize the need for interdisciplinary collaboration to address both technical and nontechnical challenges, such as sustainability, ethics, and business considerations. Finally, we propose a roadmap for future research to accelerate the development of micro/nanorobots, positioning them as essential tools for addressing grand challenges and enhancing the quality of life.
dc.description.fulltextYes
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessGold OA
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuEU
dc.description.sponsorshipGrant Agency of the Czech Republic [EXPRO: 25-15484X]; ERDF/ESF project TECHSCALE [CZ.02.01.01/00/22_008/0004587]; Czech Grant Agency GACR [25-15996S]; European Union [952152, 101047081, 853609, 101086998]; Hong Kong Research Grants Council (RGC) [R4015-2, RFS2122-4S03, STG1/E-401/23-N]; Natural Sciences and Engineering Research Council of Canada (NSERC); WIN-CEITEC BUT Joint Seed Funding Program; National Natural Science Foundation of China [22193033, U22A20346, T2322006, 52125505, U23A20637, 62375054, 52473254]; Heilongjiang Provincial Key RD Program [2022ZX02C23]; National Research Foundation of Korea (NRF) - Korea government (MSIT) [RS-2024-00435493]; Shanghai Rising-Star Program; Max Planck School Matter to Life; National Key Research and Development Program of China; MaxSynBio Consortium by the Federal Ministry of Education and Research (BMBF) of Germany; MaxSynBio Consortium by the Max Planck Society; Swiss National Science Foundation under SNSF-Sinergia [198643]; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [535275785]; European Research Council, as part of the European Union [853309]; Swiss National Science Foundation (SNSF) under the SNSF Project funding MINT 2022 [213058]; Shenzhen Science and Technology Program [RCYX20210609103122038, RCJC20231211090000001]; HORIZON-MSCA [101126600]; MICIU/AEI [PID2023-148899OA-I00]; Spanish Ministry of Science - MCIN/AEI [RYC2020-945030119-I, PID2023-151682NA-I00]; Spanish Ministry of Science - FEDER [RYC2020-945030119-I, PID2023-151682NA-I00]; Unidades de Excelencia Maria de Maeztu 2021 [CEX2021-001202-M]; National Science Foundation [CBET-2318093, CMMI 2323917, ECCS-2216131, ECCS 2339495, ECCS-2334134]; Virginia Tech Presidential Postdoctoral Fellowship; European Research Council ChessTaG [769798]; Ministry of Science and Innovation of Spain [PID2020-119914RBI00, PID2023-149206OB-I00]; Agencia de Gestion de Ayudas Universitarias y de Investigacion (AGAUR) [SGR 01538, 2022 BP 00214]; Israel Science Foundation (ISF) [2899/21]; Spanish Ministry of Science, Innovation and University - MCIN/AEI [PID2023-152298NB-I00, CNS2023-144653]; Spanish Ministry of Science, Innovation and University - FEDER, UE [PID2023-152298NB-I00]; Spanish Ministry of Science, Innovation and University - European Union [CNS2023-144653]; Junta de Comunidades de Castilla la Mancha [SBPLY/23/180225/000058]; Agencia Estatal de Investigacion (AEI) for the Maria de Maeztu [CEX2021-001202-M]; Ministerio de Ciencia, Innovacion y Universidades - MCIN/AEI [PID2020-116612RB-C33]; Generalitat de Catalunya [2021 SGR 00270, 2021 SGR 01606]; Ministerio de Ciencia, Innovacion y Universidades - MICIU/AEI [PID2022-137713NB-C21]; US Army Research Office [W911NF-18-1-0414]; National Science Foundation (NSF) through a CAREER grant [CBET 2143419]; NIH-NIBIB [R01EB017742]; European Research Council (ERC) under the European Union [866348, 866494, 101076680]; Centro de Excelencia Severo Ochoa [CEX2023-001282-S]; Ministerio de Ciencia e Innovacion of Spain (MICIN) [PID 2021-124568NB-I00, TED2021-129898B-C21]; NIH NIBIB Trailblazer R21 Award; Henry Ford Hospital + MSU Cancer Research Pilot Award; International S&T Cooperation Program of Shanghai [24490710900]; ShanghaiTech University [2023F0209-000-02]; Science and Technology Commission of Shanghai Municipality [24520750200, 24CL2900200]; Shanghai Talent Programs; Air Force Office of Scientific Research [FA9550-24-1-0185]; Sloan Foundation; Spanish Ministry of Science (MCIN/AEI); European Union (Next generation EU/PRTR) through the Ramon y Cajal grant [RYC2021-031075-I]; Australian Research Council [DP250101401, FT220100479]; National Breast Cancer Foundation, Australia [IIRS-22-104]; National Key Technologies R&D Program of China [2022YFA1207000]; [24QA2700700]; [2023YFB35070003]; European Research Council (ERC) [101076680, 101086998, 769798] Funding Source: European Research Council (ERC); Academy of Finland (AKA) [213058] Funding Source: Academy of Finland (AKA)
dc.description.versionPublished Version
dc.description.volume19
dc.identifier.doi10.1021/acsnano.5c03911
dc.identifier.eissn1936-086X
dc.identifier.embargoNo
dc.identifier.endpage24334
dc.identifier.filenameinventorynoIR06562
dc.identifier.grantno952152
dc.identifier.grantno101047081
dc.identifier.grantno853609
dc.identifier.grantno101086998
dc.identifier.issn1936-0851
dc.identifier.issue27
dc.identifier.pubmed40577644
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-105009484326
dc.identifier.startpage24174
dc.identifier.urihttps://doi.org/10.1021/acsnano.5c03911
dc.identifier.urihttps://hdl.handle.net/20.500.14288/30434
dc.identifier.wos001519731400001
dc.keywordsMicro/nanorobots
dc.keywordsSmart materials
dc.keywordsPropulsion
dc.keywordsFunctionality
dc.keywordsIntelligence
dc.keywordsCollective behavior
dc.keywordsTechnological translation
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofACS Nano
dc.relation.openaccessYes
dc.rightsCC BY (Attribution)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectChemistry, physical
dc.subjectNanoscience
dc.subjectNanotechnology
dc.titleTechnology roadmap of micro/nanorobots
dc.typeReview
dspace.entity.typePublication
person.familyNameSitti
person.givenNameMetin
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