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A narrative review of the clinical trials in sleep-related breathing disorders from 2022 to present

dc.contributor.coauthorPıhtılı A, Gündüz Gürkan C, Habeşoğlu MA, Öztürk Ö, Özsancak Uğurlu A, Taşbakan MS, Sleep Related Breathing Disorders Working Group OBOTTTS.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorPeker, Yüksel
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-01-19T10:33:55Z
dc.date.issued2023
dc.description.abstractSleep-related breathing disorders (SRBD) comprise obstructive sleep apnea (OSA), central sleep apnea (CSA), obesity-hypoventilation syndrome (OHS), as well as isolated sleep-related hypoxemia (ISRH), according to the recent International Classification of Sleep Disorders 3. During the last decades, there have been cumulative research reports indicating an association between the SRBD and increased cardiometabolic illness and death, as well as decreased quality of life. Notwithstanding, the results have been inconclusive, and the evidence level was not high regarding the effect of treatment for the SRBD on adverse outcomes. In the current work, we aim to give a comprehensive review of the clinical trials published from January 2022 to August 31, 2023. We highlight the heterogeneity of cardiometabolic disorders among adults with SRBD and particularly emphasize OSA management, drug therapy for OSA, positive airway pressure (PAP) therapy and cardiovascular outcomes, other effects of PAP in pregnancy and neurocognitive function, as well as the effects of surgical treatment and oral appliances. We also underline future directions in OSA management, telemonitoring, and druginduced sleep endoscopy in managing the SRBD, especially OSA. We ascertain that more studies are needed within the CSA, OHS, and ISRH research fields. © Author(s).
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume25
dc.identifier.doi10.5152/ThoracResPract.2023.23104
dc.identifier.eissn2979-9139
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85183182842
dc.identifier.urihttps://doi.org/10.5152/ThoracResPract.2023.23104
dc.identifier.urihttps://hdl.handle.net/20.500.14288/26673
dc.identifier.wos1190907500006
dc.keywordsCardiovascular
dc.keywordsDrug therapy
dc.keywordsObstructive sleep apnea
dc.keywordsSleep-related breathing disorders
dc.keywordsTelemedicine
dc.language.isoeng
dc.publisherAVES
dc.relation.ispartofThorac Res Pract
dc.subjectMedicine
dc.titleA narrative review of the clinical trials in sleep-related breathing disorders from 2022 to present
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorPeker, Yüksel
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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