Publication:
Emerging applications of electrochemical impedance spectroscopy in tear film analysis

dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentKUAR (KU Arçelik Research Center for Creative Industries)
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.kuauthorAtçeken, Nazente
dc.contributor.kuauthorGül, Münire
dc.contributor.kuauthorÖzdalgıç, Berin
dc.contributor.kuauthorTaşoğlu, Savaş
dc.contributor.kuauthorUygun, Zihni Onur
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T13:13:34Z
dc.date.issued2022
dc.description.abstractHuman tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, mRNA, enzymes and cytokines in the tear film, collected by noninvasive methods, can provide significant results for sustaining a predictive, preventive and personalized medicine regarding various diseases such as glaucoma, diabetic retinopathy, keratoconus, dry eye, cancer, Alzheimer’s disease, Parkinson’s disease and COVID-19. Electrochemical impedance spectroscopy (EIS) offers a powerful technique for analyzing these biomarkers. EIS detects electrical equivalent circuit parameters related to biorecognition of receptor–analyte interactions on the electrode surface. This method is advantageous as it performs a label-free detection and allows the detection of non-electroactive compounds that cannot be detected by direct electron transfer, such as hormones and some proteins. Here, we review the opportunities regarding the integration of EIS into tear fluid sampling approaches.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuEU - TÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.sponsorship2232 International Fellowship for Outstanding Researchers Award
dc.description.sponsorshipEuropean Union (EU)
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipMarie Sklodowska-Curie Individual Fellowship
dc.description.sponsorshipRoyal Academy Newton-Katip Çelebi Transforming Systems Through Partnership Award
dc.description.sponsorshipAlexander von Humboldt Research Fellowship for Experienced Researchers
dc.description.versionPublisher version
dc.description.volume12
dc.identifier.doi10.3390/bios12100827
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR04032
dc.identifier.issn2079-6374
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85140366406
dc.identifier.urihttps://doi.org/10.3390/bios12100827
dc.identifier.wos872260200001
dc.keywordsBiosensing
dc.keywordsElectrochemical impedance spectroscopy
dc.keywordsOcular diagnosis
dc.keywordsSystemic disease diagnosis
dc.keywordsTear fluid
dc.language.isoeng
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI)
dc.relation.grantno120N019
dc.relation.grantno 101003361
dc.relation.grantno 118C391
dc.relation.ispartofBiosensors
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10912
dc.subjectChemistry
dc.subjectScience and technology
dc.subjectOther topics
dc.subjectInstruments and instrumentation
dc.titleEmerging applications of electrochemical impedance spectroscopy in tear film analysis
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorTaşoğlu, Savaş
local.contributor.kuauthorÖzdalgıç, Berin
local.contributor.kuauthorGül, Münire
local.contributor.kuauthorAtçeken, Nazente
local.contributor.kuauthorUygun, Zihni Onur
local.publication.orgunit1College of Engineering
local.publication.orgunit1Research Center
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUAR (KU Arçelik Research Center for Creative Industries)
local.publication.orgunit2Department of Mechanical Engineering
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