Publication: Emerging applications of electrochemical impedance spectroscopy in tear film analysis
dc.contributor.department | Department of Mechanical Engineering | |
dc.contributor.department | KUAR (KU Arçelik Research Center for Creative Industries) | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.kuauthor | Atçeken, Nazente | |
dc.contributor.kuauthor | Gül, Münire | |
dc.contributor.kuauthor | Özdalgıç, Berin | |
dc.contributor.kuauthor | Taşoğlu, Savaş | |
dc.contributor.kuauthor | Uygun, Zihni Onur | |
dc.contributor.schoolcollegeinstitute | College of Engineering | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.date.accessioned | 2024-11-09T13:13:34Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Human tear film, with a flow rate of 1–3 µL/min, is a rich bodily fluid that transmits a variety of metabolites and hormones containing proteins, lipids and electrolytes that provide clues about ocular and systemic diseases. Analysis of disease biomarkers such as proteins, mRNA, enzymes and cytokines in the tear film, collected by noninvasive methods, can provide significant results for sustaining a predictive, preventive and personalized medicine regarding various diseases such as glaucoma, diabetic retinopathy, keratoconus, dry eye, cancer, Alzheimer’s disease, Parkinson’s disease and COVID-19. Electrochemical impedance spectroscopy (EIS) offers a powerful technique for analyzing these biomarkers. EIS detects electrical equivalent circuit parameters related to biorecognition of receptor–analyte interactions on the electrode surface. This method is advantageous as it performs a label-free detection and allows the detection of non-electroactive compounds that cannot be detected by direct electron transfer, such as hormones and some proteins. Here, we review the opportunities regarding the integration of EIS into tear fluid sampling approaches. | |
dc.description.fulltext | YES | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 10 | |
dc.description.openaccess | YES | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | EU - TÜBİTAK | |
dc.description.sponsorship | Scientific and Technological Research Council of Turkey (TÜBİTAK) | |
dc.description.sponsorship | 2232 International Fellowship for Outstanding Researchers Award | |
dc.description.sponsorship | European Union (EU) | |
dc.description.sponsorship | Horizon 2020 | |
dc.description.sponsorship | Marie Sklodowska-Curie Individual Fellowship | |
dc.description.sponsorship | Royal Academy Newton-Katip Çelebi Transforming Systems Through Partnership Award | |
dc.description.sponsorship | Alexander von Humboldt Research Fellowship for Experienced Researchers | |
dc.description.version | Publisher version | |
dc.description.volume | 12 | |
dc.identifier.doi | 10.3390/bios12100827 | |
dc.identifier.embargo | NO | |
dc.identifier.filenameinventoryno | IR04032 | |
dc.identifier.issn | 2079-6374 | |
dc.identifier.quartile | N/A | |
dc.identifier.scopus | 2-s2.0-85140366406 | |
dc.identifier.uri | https://doi.org/10.3390/bios12100827 | |
dc.identifier.wos | 872260200001 | |
dc.keywords | Biosensing | |
dc.keywords | Electrochemical impedance spectroscopy | |
dc.keywords | Ocular diagnosis | |
dc.keywords | Systemic disease diagnosis | |
dc.keywords | Tear fluid | |
dc.language.iso | eng | |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
dc.relation.grantno | 120N019 | |
dc.relation.grantno | 101003361 | |
dc.relation.grantno | 118C391 | |
dc.relation.ispartof | Biosensors | |
dc.relation.uri | http://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10912 | |
dc.subject | Chemistry | |
dc.subject | Science and technology | |
dc.subject | Other topics | |
dc.subject | Instruments and instrumentation | |
dc.title | Emerging applications of electrochemical impedance spectroscopy in tear film analysis | |
dc.type | Review | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Taşoğlu, Savaş | |
local.contributor.kuauthor | Özdalgıç, Berin | |
local.contributor.kuauthor | Gül, Münire | |
local.contributor.kuauthor | Atçeken, Nazente | |
local.contributor.kuauthor | Uygun, Zihni Onur | |
local.publication.orgunit1 | College of Engineering | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | KUAR (KU Arçelik Research Center for Creative Industries) | |
local.publication.orgunit2 | Department of Mechanical Engineering | |
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relation.isParentOrgUnitOfPublication.latestForDiscovery | 8e756b23-2d4a-4ce8-b1b3-62c794a8c164 |
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