Publication:
Regional differences in stage III nonseminoma germ cell tumor patients across seer registries

dc.contributor.coauthorCano Garcia, Cristina
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorPiccinelli, Mattia Luca
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorMorra, Simone
dc.contributor.coauthorScheipner, Lukas
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorAhyai, Sascha
dc.contributor.coauthorLongo, Nicola
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorBanek, Severine
dc.contributor.coauthorKluth, Luis A.
dc.contributor.coauthorChun, Felix K.H.
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:57Z
dc.date.issued2024
dc.description.abstractPurpose: We investigated regional differences in patients with stage III nonseminoma germ cell tumor (NSGCT). Specifically, we investigated differences in baseline patient, tumor characteristics and treatment characteristics, as well as cancer-specific mortality (CSM) across different regions of the United States. Methods: Using the Surveillance, Epidemiology, and End Results (SEER) database (2004-2018), patient (age, race/ethnicity), tumor (International Germ Cell Cancer Collaborative Group [IGCCCG] prognostic groups) and treatment (systemic therapy and retroperitoneal lymph dissection [RPLND] status) characteristics were tabulated for stage III NSGCT patients, according to 12 SEER registries representing different geographic regions. Multinomial regression models and multivariable Cox regression models testing for cancer-specific mortality (CSM) were used. Results: In 3,174 stage III NSGCT patients, registry-specific patient counts ranged from 51 (1.5%) to 1630 (51.3%). Differences across registries existed for age (12%-31% for age 40+), race/ethnicity (5%-73% for others than non-Hispanic whites), IGCCCG prognostic groups (24%-43% vs. 14-24% vs. 3%-20%, in respectively poor vs. intermediate vs. good prognosis), systemic therapy (87%-96%) and RPLND status (12%-35%). After adjustment, clinically meaningful inter-registry differences remained for systemic therapy (84%-97%) and RPLND (11%-32%). Unadjusted 5-year CSM rates ranged from 7.1% to 23.3%. Finally in multivariable analyses addressing CSM, 2 registries exhibited more favorable outcomes than SEER registry of reference (SEER Registry 12): SEER Registry 4 (Hazard Ratio (HR): 0.36) and SEER Registry 9 (HR: 0.64;both P = .004). Conclusion: We identified important regional differences in patient, tumor and treatment characteristics, as well as CSM which may be indicative of regional differences in quality of care or expertise in stage III NGSCT management.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume22
dc.identifier.doi10.1016/j.clgc.2024.102161
dc.identifier.eissn1938-0682
dc.identifier.issn1558-7673
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85201459062
dc.identifier.urihttps://doi.org/10.1016/j.clgc.2024.102161
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22198
dc.identifier.wos1318579500001
dc.keywordsNon-seminoma
dc.keywordsSEER
dc.keywordsStage III
dc.keywordsTreatment
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofClinical Genitourinary Cancer
dc.subjectOncology
dc.subjectUrology and nephrology
dc.titleRegional differences in stage III nonseminoma germ cell tumor patients across seer registries
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
local.publication.orgunit2School of Medicine
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