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Detection of human kappa-opioid antibody using microresonators with integrated optical readout

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dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.departmentDepartment of Mechanical Engineering
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAlaca, Burhanettin Erdem
dc.contributor.kuauthorKavaklı, İbrahim Halil
dc.contributor.kuauthorKılıç, M. Salih
dc.contributor.kuauthorNargül, Sezin
dc.contributor.kuauthorÖzber, Natali
dc.contributor.kuauthorTimurdoğan, Erman
dc.contributor.kuauthorÜrey, Hakan
dc.contributor.kuauthorYavuz, Serhat
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.date.accessioned2024-11-09T22:52:53Z
dc.date.issued2010
dc.description.abstractLabel-free detection of the interaction between hexahistidine-tagged human kappa-opioid receptor membrane protein and anti-His antibody is demonstrated in liquid by an optical microelectromechanical system utilizing electromagnetically actuated microresonators Shift in resonance frequency due to accretion of mass on the sensitive surface of microresonators is monitored via an integrated optical readout a frequency resolution of 2 Hz is obtained Together with a sensitivity of 7 ppm/(ng/ml)) this leads to a minimum detectable antibody concentration of 57 ng/ml for a 50-kHz device the measurement principle is shown to impart immunity to environmental noise, facilitate operation in liquid media and bring about the prospect for further miniaturization of actuator and readout leading to a portable biochemical sensor.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipTUBITAK[105E148, 109E222]
dc.description.sponsorshipTUBa-GEBIP authors acknowledge support by TUBITAKunder Grant No. 105E148 and 109E222. the work of B. E. alaca, H. Urey and I. H. Kayakli was supported by a TUBa-GEBIP Distinguished Young Scientist award.
dc.description.volume26
dc.identifier.doi10.1016/j.bios.2010.06.004
dc.identifier.eissn1873-4235
dc.identifier.issn0956-5663
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-79953767822
dc.identifier.urihttps://doi.org/10.1016/j.bios.2010.06.004
dc.identifier.urihttps://hdl.handle.net/20.500.14288/7097
dc.identifier.wos282560500031
dc.keywordsMicrocantilever immunosensor
dc.keywordsResonator
dc.keywordsElectromagnetic actuation
dc.keywordsDiffraction grating interferometry
dc.keywordsintegrated readout
dc.keywordsProtein-antibody interaction
dc.language.isoeng
dc.publisherElsevier advanced Technology
dc.relation.ispartofBiosensors and Bioelectronics
dc.subjectBiophysics
dc.subjectBiotechnology
dc.subjectMicrobiology
dc.subjectChemistry, Analytic
dc.subjectElectrochemistry
dc.subjectNanoscience
dc.subjectNanotechnology
dc.titleDetection of human kappa-opioid antibody using microresonators with integrated optical readout
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTimurdoğan, Erman
local.contributor.kuauthorÖzber, Natali
local.contributor.kuauthorNargül, Sezin
local.contributor.kuauthorYavuz, Serhat
local.contributor.kuauthorKılıç, M. Salih
local.contributor.kuauthorKavaklı, İbrahim Halil
local.contributor.kuauthorÜrey, Hakan
local.contributor.kuauthorAlaca, Burhanettin Erdem
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Mechanical Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2Department of Electrical and Electronics Engineering
local.publication.orgunit2Graduate School of Sciences and Engineering
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