Publication:
How do we make progress in phenotyping patients with LUT such as OAB and underactive detrusor, including using urine markers and microbiome data, in order to personalize therapy? ICI-RS 2023 - Part 1

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SCHOOL OF MEDICINE
Upper Org Unit

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KU Authors

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Agro, Enrico Finazzi
Rosato, Eleonora
Wagg, Adrian
Sinha, Sanjay
Spicchiale, Claudia Fede
Serati, Maurizio
Mancini, Vito
de Rijk, Mathijs
Wein, Alan
Abrams, Paul

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Abstract

IntroductionOveractive bladder (OAB) and Underactive bladder (UAB) could be associated with metabolic syndrome, affective disorders, sex hormone deficiency, changes in urinary microbiota, functional gastrointestinal disorders, or autonomic nervous system dysfunction.ObjectivesThe aim of this Think Tank was to provide a guide on how to investigate OAB and/or detrusor underactivity (DU) patients to better clarify the underlying pathophysiology and possibly personalize the treatment.MethodsA compendium of discussion based on the current evidence related to phenotyping patients with OAB or DU investigating metabolic, neurogical, psychological and gastrointestinal aspects with the aim to personalize the treatment.Results and ConclusionsThe article emphasizes the critical significance of adopting a comprehensive yet tailored approach to phenotyping patients with lower urinary tract symptoms, such as OAB and UAB. The intricate interplay between the lower urinary tract and various factors, metabolic, neurological, psychological, and gastrointestinal can define unique LUT profiles, enabling personalized therapies to replace the one-size-fits-all approach.

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Wiley

Subject

Urology and nephrology

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Has Part

Source

Neurourology and Urodynamics

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DOI

10.1002/nau.25377

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