Anaplastic multiple myeloma: an aggressive Myeloma variant with a poor response to autologous stem cell transplantation

Abstract

Anaplastic multiple myeloma is an aggressive, chemotherapy-resistant subtype of myeloma with a poor prognosis. Approximately 2% of plasma cell myelomas are pleomorphic, anaplastic, and resemble metastatic tumor cells. Morphological differentiation of anaplastic cells is difficult, and immunohistochemistry and flow cytometry should be performed for immunophenotyping. We shared our experience with peripheral stem cell transplantation in this rare malignancy.

Anaplastik multipl miyeloma agresif seyirli, kemoterapilere dirençli, kötü prognozlu miyeloma alt tipidir. Plazma hücreli miyelomun yaklaşık %2’si pleomorfik, anaplastik özellikte olup metastatik tümör hücrelerine benzer. Anaplastik hücrelerin morfolojik ayırımı güç olup, immünfenotipleme için immünhistokimya ve akım sitometrik inceleme yapılmalıdır. Nadir görülen bu malignitede otolog periferik kök hücre nakil deneyimimizi paylaştık.