Publication:
Contemporary conditional cancer-specific survival rates in surgically treated adrenocortical carcinoma patients: a stage-specific analysis

dc.contributor.coauthorPanunzio, Andrea
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorCano Garcia, Cristina
dc.contributor.coauthorPiccinelli, Mattia
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorLaw, Kyle W.
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorTafuri, Alessandro
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorChun, Felix K. H.
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorBourdeau, Isabelle
dc.contributor.coauthorCerruto, Maria A.
dc.contributor.coauthorAntonelli, Alessandro
dc.contributor.coauthorKarakiewicz, Pierre I. Panunzio, Andrea
dc.contributor.coauthorBarletta, Francesco
dc.contributor.coauthorTappero, Stefano
dc.contributor.coauthorCano Garcia, Cristina
dc.contributor.coauthorPiccinelli, Mattia
dc.contributor.coauthorIncesu, Reha-Baris
dc.contributor.coauthorLaw, Kyle W.
dc.contributor.coauthorTian, Zhe
dc.contributor.coauthorTafuri, Alessandro
dc.contributor.coauthorDe Cobelli, Ottavio
dc.contributor.coauthorChun, Felix K. H.
dc.contributor.coauthorTerrone, Carlo
dc.contributor.coauthorBriganti, Alberto
dc.contributor.coauthorSaad, Fred
dc.contributor.coauthorShariat, Shahrokh F.
dc.contributor.coauthorBourdeau, Isabelle
dc.contributor.coauthorCerruto, Maria A.
dc.contributor.coauthorAntonelli, Alessandro
dc.contributor.coauthorKarakiewicz, Pierre I.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorTilki, Derya
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:18:06Z
dc.date.issued2023
dc.description.abstractBackground and Objectives: We examined the effect of disease-free interval (DFI) duration on cancer-specific mortality (CSM)-free survival, otherwise known as the effect of conditional survival, in surgically treated adrenocortical carcinoma (ACC) patients. Methods: Within the Surveillance, Epidemiology, and End Results database (2004−2018), 867 ACC patients treated with adrenalectomy were identified. Conditional survival estimates at 5-years were assessed based on DFI duration and according to stage at presentation. Separate Cox regression models were fitted at baseline and according to DFI. Results: Overall, 406 (47%), 285 (33%), and 176 (20%) patients were stage I−II, III and IV, respectively. In conditional survival analysis, providing a DFI of 24 months, 5-year CSM-free survival at initial diagnosis increased from 66% to 80% in stage I−II, from 35% to 66% in stage III, and from 14% to 36% in stage IV. In multivariable Cox regression models, stage III (hazard ratio [HR]: 2.38; p < 0.001) and IV (HR: 4.67; p < 0.001) independently predicted higher CSM, relative to stage I−II. The magnitude of this effect decreased over time, providing increasing DFI duration. Conclusions: In surgically treated ACC, survival probabilities increase with longer DFI duration. This improvement is more pronounced in stage III, followed by stages IV and I−II patients, in that order. Survival estimates accounting for DFI may prove valuable in patients counseling.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume127
dc.identifier.doi10.1002/jso.27161
dc.identifier.eissn1096-9098
dc.identifier.issn0022-4790
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85142759103
dc.identifier.urihttps://doi.org/10.1002/jso.27161
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10328
dc.keywordsACC
dc.keywordsAdrenalectomy
dc.keywordsConditional survival
dc.language.isoeng
dc.publisherJohn Wiley and Sons Inc
dc.relation.ispartofJournal of Surgical Oncology
dc.subjectSurgery
dc.subjectOncology
dc.titleContemporary conditional cancer-specific survival rates in surgically treated adrenocortical carcinoma patients: a stage-specific analysis
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTilki, Derya
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files