Editorial expression of concern: generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization

Abstract

Editorial Expression of Concern to: Oncogenehttps://doi.org/10.1038/s41388-021-01697-6, published online 25 March 2021 The Editors-in-Chief would like to alert the readers that concerns have been raised regarding some of the figures presented in this article [1]. Specifically: The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The authors have provided the raw data pertaining to Figs. 4A, 4F and 6B and stated that the errors in the panels in question occurred during manuscript preparation inadvertently. The conclusions of these figures remain unchanged. However, the original images for Fig. 6E are no longer available. Readers are therefore advised to interpret these results with caution. All authors agree to this Editorial Expression of Concern.