Publication:
Treatment outcome and mortality among geriatric patients diagnosed with multiple-drug resistant tuberculosis: a comparative analysis from a tertiary referral center

dc.contributor.coauthorOnur, Seda Tural
dc.contributor.coauthorOrtaköylü, Mediha Gönenç
dc.contributor.coauthorAlkan, Figen
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorİliaz, Sinem
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-11-09T11:37:54Z
dc.date.issued2021
dc.description.abstractAim: multidrug-resistant (MDR) tuberculosis (TB) and drug-sensitive-TB have long treatment periods which affect patient compliance and treatment outcomes. We planned to determine the factors that will affect the management of this disease in the elderly population. Methods: in a period of two years, a total of 82 elderly patients with bacteriologically proven TB enrolled into our retrospective study between 2011-2018. The patients' demographic features, laboratory findings, and hospital records were analyzed. Results: we enrolled 67 (87.7%) patients with drug-sensitive TB and 15 (18.2%) MDR-TB in our study. In the study population, 73.2% (n=60) were male and the mean age was 75 +/- 9 years. When we compare treatment complications of MDR-TB and drug-sensitive-TB, we found out the rate of electrolyte imbalance, nephrotoxicity, and ocular toxicity more common among the MDR-TB group (p=0.008, p=0.008, and p=0.032, respectively). When we compare the mortality rate, cure, and treatment success between MDR-TB and drug sensitive TB, there were no statistically significant results (p=0.898, p=0.549, p=0.488; respectively). Conclusion: however, we think that this was due to the low sample size. Nevertheless, we should be careful in terms of complications management of the geriatric population.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyTR Dizin
dc.description.openaccessYES
dc.description.publisherscopeNational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume59
dc.identifier.doi10.4274/haseki.galenos.2021.7596
dc.identifier.eissn2147-2688
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03409
dc.identifier.issn1302-0072
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85120671032
dc.identifier.urihttps://doi.org/10.4274/haseki.galenos.2021.7596
dc.identifier.wos729649700005
dc.keywordsGeriatric
dc.keywordsMortality
dc.keywordsPulmonary
dc.keywordsTuberculosis
dc.keywordsMultidrug resistant
dc.language.isoeng
dc.publisherGalenos Yayınevi
dc.relation.grantnoNA
dc.relation.ispartofThe Medical Bulletin of Haseki / Haseki Tıp Bülteni
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10195
dc.subjectGeneral and internal medicine
dc.titleTreatment outcome and mortality among geriatric patients diagnosed with multiple-drug resistant tuberculosis: a comparative analysis from a tertiary referral center
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorİliaz, Sinem
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

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