Publication:
Pre-chemoradiotherapy low hemoglobin levels indicate increased osteoradionecrosis risk in locally advanced nasopharyngeal cancer patients

dc.contributor.coauthorYilmaz, B.
dc.contributor.coauthorSomay, E.
dc.contributor.coauthorTopkan, E.
dc.contributor.coauthorPehlivan, B.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSelek, Uğur
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:40:26Z
dc.date.issued2023
dc.description.abstractPurpose: We aimed to determine whether pretreatment hemoglobin (Hb) levels can predict the risk of osteoradionecrosis (ORN) in patients receiving concurrent chemoradiotherapy (CCRT) for locally advanced nasopharyngeal carcinoma (LA-NPC). Methods: ORN cases were identified from the records of LA-NPCs who had oral exams before and after CCRT. All Hb measurements were obtained on the first day of treatment. Receiving operating characteristic curve analysis was used to determine the relationship between Hb levels and ORN rates. The relationship between pretreatment Hb levels and ORN rates served as the primary endpoint, and secondary endpoints included the discovery of additional potential ORN risk factors. Results: Among the 263 eligible LA-NPCs, we identified 8.7% ORN cases. The ideal cutoff Hb before CCRT was 10.6 g/dL. It was revealed that HPR ≤ 10.6 group had a significantly higher ORN rate (32.5% vs. 1.5% for Hb > 10.6; P < 0.001). The mandibular V59.8 ≥ 36% Gy, pre-CCRT ≥ 4 tooth extractions, the presence of post-CCRT tooth extractions, and the time of post-CCRT tooth extractions > 8 months were the other factors associated with significantly increased ORN rates (P < 0.05 for each). Conclusion: Low pre-CCRT Hb levels appeared to be independently linked to significantly higher ORN rates. Pretreatment Hb levels may be used to establish preventive measures and predict ORN.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume280
dc.identifier.doi10.1007/s00405-023-07864-7
dc.identifier.eissn1434-4726
dc.identifier.issn0937-4477
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85147555640
dc.identifier.urihttps://doi.org/10.1007/s00405-023-07864-7
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23321
dc.identifier.wos928561000001
dc.keywordsCarcinoma
dc.keywordsChemoradiotherapy
dc.keywordsHemoglobins
dc.keywordsHumans
dc.keywordsNasopharyngeal carcinoma
dc.keywordsNasopharyngeal neoplasms
dc.keywordsOsteoradionecrosis
dc.language.isoeng
dc.publisherSpringer Science and Business Media Deutschland GmbH
dc.relation.ispartofEuropean Archives of Oto-Rhino-Laryngology
dc.subjectOtorhinolaryngology
dc.titlePre-chemoradiotherapy low hemoglobin levels indicate increased osteoradionecrosis risk in locally advanced nasopharyngeal cancer patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSelek, Uğur
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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