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Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy

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dc.contributor.coauthorErkısa, Merve
dc.contributor.coauthorUlukaya, Engin
dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentDepartment of Physics
dc.contributor.departmentKUBAM (Koç University Boron and Advanced Materials Application and Research Center)
dc.contributor.departmentKUTEM (Koç University Tüpraş Energy Center)
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.departmentDepartment of Electrical and Electronics Engineering
dc.contributor.facultymemberYes
dc.contributor.kuauthorAcar, Havva Funda Yağcı
dc.contributor.kuauthorÇelikbaş, Eda
dc.contributor.kuauthorGündüz, Hande
dc.contributor.kuauthorKhan, Minahil
dc.contributor.kuauthorKölemen, Safacan
dc.contributor.kuauthorMuti, Abdullah
dc.contributor.kuauthorOnbaşlı, Kübra
dc.contributor.kuauthorSavani, Samira
dc.contributor.kuauthorSennaroğlu, Alphan
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.date.accessioned2024-11-09T23:18:47Z
dc.date.issued2022
dc.description.abstractA cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessNO
dc.description.peerreviewstatusN/A
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipSK thanks BAGEP award of Science Academy for the financial support. Authors thank Kübra Nur Özvural Sertçelik for the graphical abstract.
dc.description.sponsorshipBilim Akademisi
dc.description.studentonlypublicationNo
dc.description.studentpublicationYes
dc.description.versionN/A
dc.identifier.WoSQuartileQ1
dc.identifier.doi10.1016/j.bioorg.2022.105725
dc.identifier.eissn1090-2120
dc.identifier.embargoN/A
dc.identifier.issn0045-2068
dc.identifier.pubmed35316664
dc.identifier.scopus2-s2.0-85126525592
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2022.105725
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10444
dc.identifier.volume122
dc.identifier.wos000788718500004
dc.keywordsPhototherapy
dc.keywordsTheranostics
dc.keywordsHemicyanine
dc.keywordsCysteine
dc.keywordsPhotosensitizers
dc.keywordsCancer
dc.language.isoeng
dc.publisherAcademic Press Inc.
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofBioorganic Chemistry
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectBiochemistry
dc.subjectMolecular biology
dc.subjectChemistry
dc.titleDevelopment of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorSavani, Samira
local.contributor.kuauthorOnbaşlı, Kübra
local.contributor.kuauthorGündüz, Hande
local.contributor.kuauthorÇelikbaş, Eda
local.contributor.kuauthorMuti, Abdullah
local.contributor.kuauthorKhan, Minahil
local.contributor.kuauthorSennaroğlu, Alphan
local.contributor.kuauthorAcar, Havva Funda Yağcı
local.contributor.kuauthorKölemen, Safacan
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