Publication: Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
dc.contributor.coauthor | Erkısa, Merve | |
dc.contributor.coauthor | Ulukaya, Engin | |
dc.contributor.department | Department of Physics | |
dc.contributor.department | Department of Chemistry | |
dc.contributor.kuauthor | Savani, Samira | |
dc.contributor.kuauthor | Onbaşlı, Kübra | |
dc.contributor.kuauthor | Gündüz, Hande | |
dc.contributor.kuauthor | Çelikbaş, Eda | |
dc.contributor.kuauthor | Muti, Abdullah | |
dc.contributor.kuauthor | Khan, Minahil | |
dc.contributor.kuauthor | Sennaroğlu, Alphan | |
dc.contributor.kuauthor | Acar, Havva Funda Yağcı | |
dc.contributor.kuauthor | Kölemen, Safacan | |
dc.contributor.kuprofile | Master Student | |
dc.contributor.kuprofile | PhD Student | |
dc.contributor.kuprofile | Researcher | |
dc.contributor.kuprofile | PhD Student | |
dc.contributor.kuprofile | PhD Student | |
dc.contributor.kuprofile | PhD Student | |
dc.contributor.kuprofile | Faculty Member | |
dc.contributor.kuprofile | Faculty Member | |
dc.contributor.kuprofile | Faculty Member | |
dc.contributor.yokid | N/A | |
dc.contributor.yokid | 365341 | |
dc.contributor.yokid | 224496 | |
dc.contributor.yokid | N/A | |
dc.contributor.yokid | N/A | |
dc.contributor.yokid | N/A 23851 | |
dc.contributor.yokid | 178902 | |
dc.contributor.yokid | 272051 | |
dc.date.accessioned | 2024-11-09T23:18:47Z | |
dc.date.issued | 2022 | |
dc.description.abstract | A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and activated its singlet oxygen generation as well as photothermal conversion potentials upon reacting with Cys. The laser irradiation of Cl-Cys induced significant cell death in cancer cells with high Cys level, while it stayed deactivated and non-emissive in a healthy cell line. A profound synergistic PDT/PTT effect was observed at high doses. Remarkably, Cl-Cys marks the first ever example of Cys-responsive small organic-based therapeutic agent and holds a great promise to develop new activity-based photosensitizers for dual phototherapy action. | |
dc.description.indexedby | WoS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.openaccess | NO | |
dc.description.publisherscope | International | |
dc.description.volume | 122 | |
dc.identifier.doi | 10.1016/j.bioorg.2022.105725 | |
dc.identifier.eissn | 1090-2120 | |
dc.identifier.issn | 0045-2068 | |
dc.identifier.quartile | Q1 | |
dc.identifier.scopus | 2-s2.0-85126525592 | |
dc.identifier.uri | http://dx.doi.org/10.1016/j.bioorg.2022.105725 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/10444 | |
dc.identifier.wos | 788718500004 | |
dc.keywords | Phototherapy | |
dc.keywords | Theranostics | |
dc.keywords | Hemicyanine | |
dc.keywords | Cysteine | |
dc.keywords | Photosensitizers | |
dc.keywords | Cancer | |
dc.language | English | |
dc.publisher | Elsevier | |
dc.source | Bioorganic Chemistry | |
dc.subject | Biochemistry | |
dc.subject | Molecular biology | |
dc.subject | Chemistry, organic | |
dc.title | Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.authorid | 0000-0002-7663-1824 | |
local.contributor.authorid | 0000-0001-6573-8565 | |
local.contributor.authorid | 0000-0001-7828-892X | |
local.contributor.authorid | 0000-0003-4882-6445 | |
local.contributor.authorid | N/A | |
local.contributor.authorid | 0000-0003-1675-7369 | |
local.contributor.authorid | 0000-0003-4391-0189 | |
local.contributor.authorid | 0000-0001-5601-8814 | |
local.contributor.authorid | 0000-0003-4162-5587 | |
local.contributor.kuauthor | Savani, Samira | |
local.contributor.kuauthor | Onbaşlı, Kübra | |
local.contributor.kuauthor | Gündüz, Hande | |
local.contributor.kuauthor | Çelikbaş, Eda | |
local.contributor.kuauthor | Muti, Abdullah | |
local.contributor.kuauthor | Khan, Minahil | |
local.contributor.kuauthor | Sennaroğlu, Alphan | |
local.contributor.kuauthor | Acar, Havva Funda Yağcı | |
local.contributor.kuauthor | Kölemen, Safacan | |
local.publication.orgunit1 | Graduate School of Sciences and Engineering | |
local.publication.orgunit1 | College of Sciences | |
local.publication.orgunit2 | Department of Chemistry | |
local.publication.orgunit2 | Department of Physics | |
local.publication.orgunit2 | KUYTAM (Koç University Surface Science and Technology Center) | |
local.publication.orgunit2 | KUBAM (Koç University Boron and Advanced Materials Application and Research Center) | |
local.publication.orgunit2 | KUTEM (Koç University Tüpraş Energy Center) | |
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