COST action CA22103 Net4Brain: Pan-European network advancing translational research in brain cancer

Abstract

Brain and central nervous system cancers remain the deadliest forms of cancer, with limited improvement in survival following treatment. The Net4Brain COST Action (CA22103) addresses the urgent need for coordinated and multidisciplinary approaches to understand the pathogenesis, optimize early diagnosis, and personalize treatment strategies. Net4Brain unites a pan-European network of experts in basic and clinical neuroscience, oncology, molecular biology, data science and bioengineering. Through five thematic Working Groups (WGs), innovative Young Researchers Group and one dissemination WG, supported by Creative Group, the Action focuses on non-invasive biomarker discovery, preclinical modeling, tumor profiling, computational modeling, and treatment optimization. This initiative supports collaborative research, capacity building, and the development of a shared pan-European brain cancer centralized virtual database and biobank. Progress has been made in standardizing biomarker discovery, building innovative advanced preclinical models, and fostering integration of "omics" and imaging data for clinical applications. Net4Brain overcomes existing fragmentation in brain cancer research by providing a transdisciplinary platform for research and development, innovation, dissemination, and training, ultimately aiming to improve diagnostic accuracy, therapeutic outcomes, and patient quality of life. It also builds critical mass of knowledge/experts in the field of brain cancer and neuro-oncology.