Publication:
Neuroprotective effects of halofuginone in Rat's sciatic nerve injury

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dc.contributor.coauthorŞahin, Ömer
dc.contributor.coauthorTaşçıoğlu, Tuncer
dc.contributor.coauthorFırat, Ayşegül
dc.contributor.coauthorÇaydere, Muzaffer
dc.contributor.coauthorCemil, Duran Berker
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorSürücü, Hüseyin Selçuk
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2025-05-22T10:33:32Z
dc.date.available2025-05-22
dc.date.issued2025
dc.description.abstractObjective: The object of the present study was to investigate the neuroprotective effects of halofuginone—with its antifibrotic and anti-inflammatory effects—on peripheral nerve injuries frequently encountered in daily life, at the functional, pathological, and cellular levels through the use of electron microscopy. Methods: Forty Wistar rats were distributed into 4 groups. Group 1 (sham group) consisted of rats with only exposed nerves; group 2 (control group) consisted of traumatized rats; group 3 (methylprednisolone [MP] group) consisted of rats receiving MP treatment after trauma; group 4 (halofuginone group) consisted of rats receiving halofuginone treatment after trauma. The rats were decapitated after one month. During this period, gait track analysis, muscle mass ratio, and pathological and electron microscopic evaluations were performed. Results: Significant functional improvement was observed in the animal groups receiving MP and halofuginone compared to the trauma group. It was determined that halofuginone and MP provided improvement in peripheral nerve structure at both the pathological and cellular levels. Conclusions: Halofuginone has peripheral nerve protective effects on a rat peripheral nerve injury model. © 2025 The Author(s)
dc.description.fulltextYes
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessGold OA
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionPublished Version
dc.identifier.doi10.1016/j.wneu.2025.123877
dc.identifier.eissn1878-8769
dc.identifier.embargoNo
dc.identifier.filenameinventorynoIR06184
dc.identifier.issn1878-8750
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-105000915465
dc.identifier.urihttps://hdl.handle.net/20.500.14288/29286
dc.identifier.urihttps://doi.org/10.1016/j.wneu.2025.123877
dc.identifier.volume197
dc.identifier.wos001461537400001
dc.keywordsAnti-inflammatory
dc.keywordsHalofuginone
dc.keywordsMethylprednisolone
dc.keywordsPeripheral nerve injury
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofWorld Neurosurgery
dc.relation.openaccessNo
dc.rightsCC BY-NC-ND (Attribution-NonCommercial-NoDerivs)
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleNeuroprotective effects of halofuginone in Rat's sciatic nerve injury
dc.typeJournal Article
dspace.entity.typePublication
person.familyNameSürücü
person.givenNameHüseyin Selçuk
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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