Publication: A hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells
dc.contributor.department | Department of Chemistry | |
dc.contributor.department | KUTTAM (Koç University Research Center for Translational Medicine) | |
dc.contributor.department | KUYTAM (Koç University Surface Science and Technology Center) | |
dc.contributor.department | Graduate School of Health Sciences | |
dc.contributor.department | Graduate School of Sciences and Engineering | |
dc.contributor.kuauthor | Acari, Alperen | |
dc.contributor.kuauthor | Kölemen, Safacan | |
dc.contributor.kuauthor | Dırak, Musa | |
dc.contributor.kuauthor | Almammadov, Toghrul | |
dc.contributor.schoolcollegeinstitute | College of Sciences | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF HEALTH SCIENCES | |
dc.contributor.schoolcollegeinstitute | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
dc.contributor.schoolcollegeinstitute | Research Center | |
dc.date.accessioned | 2025-01-19T10:28:00Z | |
dc.date.issued | 2023 | |
dc.description.abstract | A resorufin-based dual-locked fluorescent probe (RHT) was introduced to image melanoma cells selectively. RHT was shown to function as an AND molecular logic gate as it emitted a signal only in the presence of both hydrogen sulfide (H2S) and tyrosinase (Tyr), which are known to be overexpressed in melanoma cells. In vitro cell culture studies revealed that RHT can be activated with endogenous H2S and Tyr and allows selective imaging of B16-F10 cancer cells under confocal microscopy. RHT marks the first ever example of a fluorescent probe that is sequentially activated by H2S and Tyr. | |
dc.description.indexedby | WOS | |
dc.description.indexedby | Scopus | |
dc.description.indexedby | PubMed | |
dc.description.issue | 66 | |
dc.description.publisherscope | International | |
dc.description.sponsoredbyTubitakEu | N/A | |
dc.description.sponsorship | This study was supported by the Turkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program. The authors are grateful to Dr Sundus Erbas Cakmak from NecmettinErbakan University for providing B16-F10 cells. We also thank Berkan Bozkurt for his help during cell studies. | |
dc.description.volume | 59 | |
dc.identifier.doi | 10.1039/d3cc02676k | |
dc.identifier.eissn | 1364-548X | |
dc.identifier.issn | 1359-7345 | |
dc.identifier.quartile | Q2 | |
dc.identifier.scopus | 2-s2.0-85167462212 | |
dc.identifier.uri | https://doi.org/10.1039/d3cc02676k | |
dc.identifier.uri | https://hdl.handle.net/20.500.14288/25657 | |
dc.identifier.wos | 1037414700001 | |
dc.keywords | Cancer cells | |
dc.keywords | Cell culture | |
dc.keywords | Cells | |
dc.keywords | Dermatology | |
dc.keywords | Fluorescence | |
dc.keywords | Locks (fasteners) | |
dc.keywords | Probes | |
dc.keywords | Sulfur determination | |
dc.language.iso | eng | |
dc.publisher | Royal Society of Chemistry | |
dc.relation.grantno | Turkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program | |
dc.relation.ispartof | Chemical Communications | |
dc.subject | Chemistry, multidisciplinary | |
dc.title | A hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells | |
dc.type | Journal Article | |
dspace.entity.type | Publication | |
local.contributor.kuauthor | Almammadov, Toghrul | |
local.contributor.kuauthor | Dırak, Musa | |
local.contributor.kuauthor | Saymaz, Ayça | |
local.contributor.kuauthor | Acari, Alperen | |
local.contributor.kuauthor | Kölemen, Safacan | |
local.publication.orgunit1 | College of Sciences | |
local.publication.orgunit1 | GRADUATE SCHOOL OF SCIENCES AND ENGINEERING | |
local.publication.orgunit1 | GRADUATE SCHOOL OF HEALTH SCIENCES | |
local.publication.orgunit1 | Research Center | |
local.publication.orgunit2 | Department of Chemistry | |
local.publication.orgunit2 | KUTTAM (Koç University Research Center for Translational Medicine) | |
local.publication.orgunit2 | KUYTAM (Koç University Surface Science and Technology Center) | |
local.publication.orgunit2 | Graduate School of Sciences and Engineering | |
local.publication.orgunit2 | Graduate School of Health Sciences | |
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