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A hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells

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dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.kuauthorAcari, Alperen
dc.contributor.kuauthorKölemen, Safacan
dc.contributor.kuauthorDırak, Musa
dc.contributor.kuauthorAlmammadov, Toghrul
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2025-01-19T10:28:00Z
dc.date.issued2023
dc.description.abstractA resorufin-based dual-locked fluorescent probe (RHT) was introduced to image melanoma cells selectively. RHT was shown to function as an AND molecular logic gate as it emitted a signal only in the presence of both hydrogen sulfide (H2S) and tyrosinase (Tyr), which are known to be overexpressed in melanoma cells. In vitro cell culture studies revealed that RHT can be activated with endogenous H2S and Tyr and allows selective imaging of B16-F10 cancer cells under confocal microscopy. RHT marks the first ever example of a fluorescent probe that is sequentially activated by H2S and Tyr.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue66
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipThis study was supported by the Turkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program. The authors are grateful to Dr Sundus Erbas Cakmak from NecmettinErbakan University for providing B16-F10 cells. We also thank Berkan Bozkurt for his help during cell studies.
dc.description.volume59
dc.identifier.doi10.1039/d3cc02676k
dc.identifier.eissn1364-548X
dc.identifier.issn1359-7345
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85167462212
dc.identifier.urihttps://doi.org/10.1039/d3cc02676k
dc.identifier.urihttps://hdl.handle.net/20.500.14288/25657
dc.identifier.wos1037414700001
dc.keywordsCancer cells
dc.keywordsCell culture
dc.keywordsCells
dc.keywordsDermatology
dc.keywordsFluorescence
dc.keywordsLocks (fasteners)
dc.keywordsProbes
dc.keywordsSulfur determination
dc.language.isoeng
dc.publisherRoyal Society of Chemistry
dc.relation.grantnoTurkish Academy of Sciences, Young Scientists (TUBA-GEBIP) program
dc.relation.ispartofChemical Communications
dc.subjectChemistry, multidisciplinary
dc.titleA hydrogen sulfide and tyrosinase responsive dual-locked fluorophore for selective imaging of melanoma cells
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAlmammadov, Toghrul
local.contributor.kuauthorDırak, Musa
local.contributor.kuauthorSaymaz, Ayça
local.contributor.kuauthorAcari, Alperen
local.contributor.kuauthorKölemen, Safacan
local.publication.orgunit1College of Sciences
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Chemistry
local.publication.orgunit2KUTTAM (Koç University Research Center for Translational Medicine)
local.publication.orgunit2KUYTAM (Koç University Surface Science and Technology Center)
local.publication.orgunit2Graduate School of Sciences and Engineering
local.publication.orgunit2Graduate School of Health Sciences
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