Publications without Fulltext

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3

Browse

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Placeholder
    PublicationMetadata only
    Relation between non-alcoholic fatty liver disease and carotid artery intimal media thickness as a surrogate for atherosclerosis: a systematic review and meta-analysis
    (Lippincott Williams and Wilkins, 2024) Abosheaishaa, Hazem; Nassar, Mahmoud; Abdelhalim, Omar; Bahbah, Ammar Ayman; Morsi, Samah M.; Ghallab, Muhammad; Alagha, Zakaria; Omran, Ahmed; Elfert, Khaled; Bandaru, Praneeth; Forlemu, Arnold Nongmoh; Reddy, Madhavi; Abbas, Sharif Omar; School of Medicine
    Background and objective Non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis without heavy alcohol consumption or other chronic conditions, encompasses a spectrum from non-alcoholic fatty liver to non-alcoholic steatohepatitis leading to cirrhosis. This analysis aimed to investigate the correlation between NAFLD and carotid intimal media thickness (C-IMT), a non-invasive surrogate for atherosclerosis. Methodology Database searches, including PubMed, EMBASE and Cochrane Library, yielded studies up to April 2023. Included were studies exploring the NAFLD-C-IMT relationship in populations aged >18 years. Exclusions comprised non-English papers, those involving animals or pediatric populations and studies lacking control groups. Results No statistical significance was noted between mild and moderate NAFLD compared to the control group regarding C-IMT [95% confidence intervals (CI): -0.03, 0.12] and (95% CI: -0.03, 0.21), respectively. There was a statistically significant difference only in the Severe NAFLD group (P value 0.03). NAFLD with and without metabolic syndrome showed statistically significant differences compared to control regarding C-IMT (95% CI: 0.04, 0.12) and (95% CI: 0.01, 0.07), respectively. Fifty-nine studies were mentioned without classification of NAFLD severity and revealed a high statistically significant difference between NAFLD and controls regarding C-IMT with (95% CI: 0.09, 0.12, P < 0.00001). Stratified analysis according to sex was done in two studies and revealed statistical differences between NAFLD and control regarding C-IMT in both groups. Conclusion This meta-analysis underscores a significant association between NAFLD and increased C-IMT, emphasizing the importance of assessing C-IMT in NAFLD patients to identify cardiovascular risk and tailor therapeutic interventions for improved patient outcomes. © 2024 Lippincott Williams and Wilkins. All rights reserved.