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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only 268th ENMC workshop - Genetic diagnosis, clinical classification, outcome measures, and biomarkers in Facioscapulohumeral Muscular Dystrophy (FSHD): Relevance for clinical trials(Elsevier B.V., 2023) Montagnese F, de Valle K, Lemmers RJLF, Mul K, Dumonceaux J, Voermans N; 268th ENMC workshop participants.; Oflazer, Piraye; ; School of Medicine;Highlights This ENMC workshop has seen the participation of many important stakeholders working together to improve trial readiness in FSHD: patients and patients’ organizations (FSHD-Europe, FSHD-Society and FSHD Global), neuromuscular clinicians, geneticists, basic researchers, representatives of the TREAT-NMD network, the FSHD-CTRN and EMA. COMs represent useful tools for the standardized collection of clinical features but need to be selected to match the clinical setting of use. For patient care, they need to be informative, with practical and time efficient utility so as not to detract from clinical care. For clinical trial purposes, the need to be reliable, valid, meaningful and sensitive to change to better depict therapeutic responses. An optimized clinical evaluation and genetic test form is one of the goals of WG1 and 2. A diagnostic flowchart for FSHD1 and FSHD2 has been proposed. Another important unmet need for clinical trial readiness in FSHD is the identification of good therapeutic biomarkers, which ideally should be quantitative, non-invasive, applicable across the entire range of disease severity, sensitive to change, reliable and clinically meaningful. The WG 3 will produce standard operating procedures (SOPs) for DUX4 detection. Similarly, large differences in the reporting of studies performed on animal models, thus hindering interpretation, repeatability and comparison of the results need to be addressed. Guidelines regarding minimum information for publication of work including animal models for FSHD will therefore be published.Publication Metadata only [68Ga]Ga-PSMA-11 and [18F]FDG uptake of venous tumor thrombus in inferior vena cava and left common iliac vein from prostate cancer on positron emission tomography(Springer Science and Business Media Deutschland GmbH, 2023) Kabaoglu, Z.U.; Seymen, Hülya; Esen, Barış; Kulaç, İbrahim; Aksoy, Murat; Demirkol, Mehmet Onur; Kordan, Yakup; School of MedicineN/APublication Metadata only A glimpse into the future of TAVR(Wiley-Blackwell, 2016) Marmagkiolis, Konstantinos; N/A; Çilingiroğlu, Mehmet; Other; School of Medicine; Koç University Hospital; N/AImportant differences still exist in the management of patients who receive TAVR in Europe and in the USA. Provisional participation of cardiovascular surgeons and imaging cardiologists, use of TEE, general anesthesia with endotracheal intubation, and length of stay are some of the major differences which may define the future of TAVR in the USA. TAVR procedure will most likely be performed without CT surgery presence and with limited echocardiographic imaging guidance in USA in the near future as it is already being done in Europe.Publication Metadata only A global brand management roadmap(Elsevier, 2012) Batra, Rajeev; Chattopadhyay, Amitava; ter Hofstede, Frenkel; Department of Business Administration; Tunalı, Ayşegül Özsomer; Faculty Member; Department of Business Administration; College of Administrative Sciences and Economics; 108158N/APublication Metadata only A late preterm infant with progressive respiratory distress(Marmara Univ, Fac Medicine, 2017) N/A; Gürsoy, Tuğba; Faculty Member; School of Medicine; Koç University Hospital; 214691A 2300 g female baby was born at 36+4 gestational age via caesarean section. Prenatal history was unremarkable. At 2 hours of age the baby was transferred to neonatal intensive care unit due to progressive respiratory distress and received poractant alfa as intubation-surfactant-extubation therapy after which FiO2 requirement decreased from 0.50 to 0.25. At 34 hours of age, while she was still on nasal continuous positive airway pressure (CPAP), she had sudden deterioration with retractions, desaturation and bradycardia. The infant was immediately intubated and put on high frequency oscillatory ventilation (HFOV) after which her oxygen saturations and heart rate stabilized.Publication Metadata only A new risk factor for cardiovascular disease and associated risk factors: education(Wiley-Blackwell, 2015) N/A; N/A; Bertelsen, Nathan; Kanbay, Mehmet; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; 110580N/APublication Metadata only A practical method for accurate coordination between the plastic surgeon and the pathologist: the clockwork technique(Korean Soc Plastic & Reconstructive Surgery, 2018) N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezgin, Billur; Kapucu, İrem; Yenidünya, Bahar Güliz; Bulutay, Pınar; Armutlu, Ayşe; Özmen, Selahattin; Yavuzer, Cahit Reha; Faculty Member; Researcher; Undergraduate Student; Teaching Faculty; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 133762; 327602; N/A; N/A; 133565; 133567; 125951; N/ACooperation between the surgeon and the pathologist is essential for the correct diagnosis and treatment of skin tumors [1]. Precise communication between these two specialties allows for the precise evaluation of the tumor borders by the pathologist, which in turn reduces the amount of unnecessary tissue removed, thereby improving functional preservation and the aesthetic outcomes of surgery. Although not every skin tumor excision requires a high level of interdisciplinary interaction, the location and the type of tumor are key elements that can make such a collaboration necessary. This is especially true for tumors located near critical facial aesthetic subunits such as the eyelids, nostrils, and mouth, and for locally aggressive tumors that spread in unpredictable patterns. Mohs micrographic surgery (MMS) is an alternative to conventional surgery in such cases, and allows tissue preservation to be maximized without compromising adequate surgical excision of the tumor [2]. MMS remains an effective, yet not commonly accessible option, as it can only be performed by pathologically trained surgeons. Nevertheless, regardless of the surgical method, establishing the orientation of the specimen is always critical, and accuracy in this regard can be achieved by various techniques, such as using sutures in different lengths or color codes for each side. Surgeons may use hand-drawn pictures, printed maps of the areas in question, and photographs to guide the patholoCOMMUNICATION A practical method for accurate coordination between the plastic surgeon and the pathologist: The clockwork technique Billur Sezgin1 , Irem Kapucu1 , Guliz Yenidunya1 , Pinar Bulutay2 , Ayse Armutlu2 , Selahattin Ozmen1 , Reha Yavuzer1 Departments of 1 Plastic, Reconstructive, and Aesthetic Surgery and 2 Pathology, Koc University School of Medicine, Istanbul, Turkey Correspondence: Billur Sezgin Department of Plastic, Reconstructive, and Aesthetic Surgery, Koç University Hospital, Maltepe Mh., Davutpasa cad. No 4, Topkapı, 34010 Zeytinburnu, Istanbul, Turkey Tel: +90-850-250-8250–20201, Fax: +90-0442-232-5300, E-mail: bsezgin@ku.edu.tr This article was presented as a poster at the 38th Congress of the Turkish Society of Plastic, Reconstructive and Aesthetic Surgeons on 27–30 October, 2016 in Antalya,Turkey. gist. Tissue nicks or poly-angulated drawings can also be used to improve the orientation [3]. These markings are especially useful when determining the need for re-excision; thus, precision is key for minimizing further tissue loss while obtaining tumor-free margins. We present an easily applicable technique that has been developed to increase the precision of surgical margin evaluation in various skin tumors. The ‘clockwork technique’ uses a clock face template for the orientation of the specimen. This method ensures accurate coordination between the surgeon excising the tumor and the pathologist who guides the surgeon in re-excision until tumor-free margins are achieved. The first step is to determine the type of the lesion via biopsies if necessary, as the safety margin will be adjusted according to the characteristics of the primary tumor. Lesions involving facial subunits may be an exception, as the required margin may not be planned accordingly in certain critical locations. The second step is to outline the approximate borders of the visually apparent tumor and to draw a safety margin that will serve as the clock face for the orientation of the specimen. Then, the periphery of the circle is numbered through 12 as in a clock (Fig. 1). The hourly markings go through both the excised specimen and the healthy tissue, so that the surgeon knows which part of the excised tissue corresponds to which ‘hour.’ The lesion is excised as a complete circle and a single suture is placed at a pre-determined hourly interval as a guide if the marking is disrupted. After microscopic examination, the pathologist can state which hour slice corresponds to a tumor-positive margin, and further excision can be carried out only in the area of that hour slice. Plastic surgeons need to work very meticulously alongside pathologists, as every millimeter of skin preserved can be used to achieve better aesthetic and functional outcomes. The clockwork technique can be applied to any type and size of lesion. It is also beneficial for tumors that have unpredictable growth patterns, where it is not possible to agree on a standard optimal safety margin, such as dermatofibrosarcoma protuberans. Moreover, in areas where aesthetic and functional preservation are concerns, it helps to preserve more healthy tissue, as further re-excision can be carried out in only onetwelfth of the excisional border. In conclusion, this technique is advantageous because it is an easily applicable and fast method that facilitates optimal communication between the surgeon and pathologist regarding specimen borders, allowing precise re-excisions that can be limited to intervals corresponding to one-twelfth of the surgical margin.Publication Metadata only A promising tool: triglyceride-glucose index to stratify the risk of cardiovascular events in chronic kidney disease(Oxford University Press (OUP), 2022) N/A; N/A; N/A; Yıldırım, Fatma; Yıldız, Abdullah Burak; Kanbay, Mehmet; Master Student; Undergraduate Student; Faculty Member; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; 110580Lipid profile management is one of the crucial components to optimize outcomes in patients with chronic kidney disease (CKD). CKD is associated with poor cardiovascular outcomes due to both a direct cardiovascular impact of CKD and the presence of metabolic comorbidities. Low-density lipoprotein cholesterol is the main target of current lipid-lowering drugs. However, the derangement of lipid metabolism in CKD is more complex. the recently described triglyceride-glucose index (TyG) is associated with cardiovascular outcomes in the general population. in recent studies, the TyG was associated with CKD progression in CKD patients and with cardiovascular death in patients on peritoneal dialysis. Quiroga et al. now show that the TyG is associated with the occurrence of major cardiovascular events in individuals free from diabetes with non-dialysis-dependent CKD.Publication Metadata only A qualitative evaluation of online active learning modalities in the chronic wound management lecture of nursing students' experiences in Turkey(Elsevier, 2022) Shoqirat, Noordeen; Singh, Charleen; Mahasneh, Deema; N/A; Şengül, Tuba; Karadağ, Ayişe; Faculty Member; Faculty Member; School of Nursing; School of Nursing; 59230; 3549N/APublication Metadata only A rare cause of AA amyloidosis and end-stage kidney failure: questions and answers(Springer, 2019) Baba, Zeliha Füsun; Taşdemir, Mehmet; Yılmaz, Sezen Güçlü; Bilge, İlmay; Faculty Member; Undergraduate Student; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 175867; N/A; 198907N/APublication Metadata only A rare cause of chronic hyponatremia in an infant: questions(Springer, 2020) Guran, Tulay; N/A; Yeşiltepe Mutlu, Rahime Gül; Taşdemir, Mehmet; Kızılkan, Nuray Uslu; Hatun, Şükrü; Kayserili, Hülya; Bilge, İlmay; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 153511; 175867; 221274; 153504; 7945; 198907N/APublication Metadata only A tour de force of primary cilium biogenesis(Nature Portfolio, 2021) N/A; Department of Molecular Biology and Genetics; Karalar, Elif Nur Fırat; Faculty Member; Department of Molecular Biology and Genetics; College of Sciences; 206349N/APublication Metadata only A tribute to Dr. Freddie H. Fu: remembering a “good friend”(Aves, 2021) Taşkıran, Emin; Kılıçoğlu, Önder; Pınar, Halit; Demirhan, Mehmet; Faculty Member; School of Medicine; 9882The orthopaedic community is deeply saddened by the loss of renowned orthopaedic surgeon Dr. Freddie H. Fu, on September 24. A relentless and irreconcilable disease has taken the “good friend” from us at the very early age of 70, when he was dwelling at the highest summit of the mountain of success he built with his own hands. Freddie was definitely a legend, but he has never been inaccessible. Apart from thousands of people he treated or restored to a higher degree of sportive performance, he built countless number of personal relationships with friends, fellows, students, and people from every possible area of the community. He never ceased to connect himself to the society and made everyone feel endeared to him, as a reason why many is mourning today and not only the orthopaedic community.Publication Metadata only Acknowledgments(Cambridge University Press (CUP), 2006) Georgas, J.; Berry, J. W.; van de Vijver, F. J. R.; Poortinga, Y. H.; Department of Psychology; Kağıtçıbaşı, Çiğdem; Faculty Member; Department of Psychology; College of Social Sciences and Humanities; N/AThis book is about similarities and differences in families across cultures. Family has been studied during the past two centuries by many disciplines, including sociology, cultural anthropology, psychology, education, psychiatry, economics, and historical demography, among other disciplines. The perspective in this book is the relationships between psychological variables, the ecocultural context of countries, and family variables. The book centers around three issues. The first examines how families differ in cultures across the world. What are the differences in family networks, family roles, and psychological variables among countries with different ecological and sociopolitical systems? The second issue examines how families are alike across cultures. That is, to what degree are features of family similar in countries throughout the word? The third issue involves family changes in societies throughout the world as a result of social changes, such as economic level, education, political systems, the global influence of television, and of communication through telephones, email, and the internet. Changes in family types in the last two centuries, as a result of industrialization and urbanization, have been described as transitions from the extended types of family systems to the nuclear family and more recently to the one-parent family. Understanding the nature of these developments is of scientific interest, but these changes are also important social issues in almost all countries throughout the world; research on the family has influenced government policies in many countries. Some family researchers as well as the media and governments talk about the crisis of the institution of family.Publication Metadata only ACM MobiCom 2012 general co-chairs' welcome(ACM, 2012) Ekici, Eylem; Department of Electrical and Electronics Engineering; Akan, Özgür Barış; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; 6647Publication Metadata only Acute kidney injury from SGLT2 inhibitors: Potential mechanisms(Nature Portfolio, 2016) Hahn, Kai; Ejaz, A. Ahsan; Lanaspa, Miguel A.; Johnson, Richard J.; N/A; Kanbay, Mehmet; Faculty Member; School of Medicine; 110580SGLT2 inhibitors have shown great promise in the management of diabetes mellitus and the prevention of cardiovascular complications, but increasing evidence suggests that their use can be associated with an increased risk of acute kidney injury. Insights into the mechanisms involved might help to identify individuals who are at risk of renal injury.Publication Metadata only ADCHEM 2009 special issue(Elsevier Sci Ltd, 2010) Engell, Sebastian; Department of Chemical and Biological Engineering; Arkun, Yaman; Faculty Member; Department of Chemical and Biological Engineering; College of Engineering; 108526Publication Metadata only Addendum to “On the mean square average of special values of L-functions” [J. Number Theory 131 (8) (2011) 1470–1485](Elsevier, 2011) Department of Mathematics; Alkan, Emre; Faculty Member; Department of Mathematics; College of Sciences; 32803Publication Metadata only Advanced practice pediatric oncology nursing as imagined or in place in four lower- and upper-middle-income countries(Elsevier Science Inc, 2024) Samba, Vera Larfi; Diaz, Dorian René Navarro; Punjwani, Rehana; Challinor, Julia; Semerci, Remziye; School of NursingObjectives: The implementation of pediatric oncology advanced practice nurse (s) roles in low- and middleincome countries (LMICs) presents opportunities and challenges. The authors explore the implications of pediatric oncology advanced practice nursing roles in Pakistan, Cameroon, Turkey, and Mexico. Potential bene fits and drawbacks of advanced practice nursing roles, impacts on nursing care, and strategies for advanced practice nursing role development in LMIC settings are considered. Methods: Information from scholarly articles, policy documents, and four LMIC pediatric oncology nurse expert perspectives on existing and imagined advanced practice nursing roles in pediatric oncology in LMIC were synthesized. Results: Current literature and policies point to efforts across LMICs to establish a wide variety of advanced nursing practices, not necessarily aligned with internationally accepted advanced practice nursing standards of practice or education. The LMIC nurses describe a wide range of national general nurse education and government advanced practice nurse recognition/licensing. Challenges to achieving or strengthening advanced practice nursing roles include, for example, healthcare professional resistance, government unwillingness to recognize/license advanced practice nurses, and lack of advanced practice nursing faculty. To promote a pediatric oncology advanced practice nursing role in LMICs requires navigating the national nursing scope of practice and nursing culture. Conclusion: The strategic introduction of pediatric oncology advanced practice nursing roles in LMICs has the potential to signi ficantly enhance patient care by, for example, addressing healthcare workforce shortages and facilitating timely care delivery. However, challenges related to role complexity, resistance from traditional healthcare structures, and role overlap must be considered. Tailoring these roles to local contexts and fostering stakeholder collaboration are essential for successful implementation. Implications for Nursing Practice: The adoption of advanced practice nursing roles can lead to improved quality of care for pediatric oncology patients and their families in LMICs, where cancer care is challenging. The positive impact of pediatric oncology advanced practice nurses on patient outcomes and healthcare delivery cannot be discounted but must align with local nursing and healthcare culture and expectations. (c) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.Publication Metadata only Aggregate investor preferences and beliefs: a comment(Elsevier Science Bv, 2013) Kopa, Milos; N/A; Post, Gerrit Tjeerd; Other; Graduate School of Business; N/AA recent study in this journal presents encouraging results of a daunting simulation analysis of the statistical properties of a centered bootstrap approach to stochastic dominance efficiency analysis. However, by relying on the first-order optimality condition in a situation where multiple optima may occur, the empirical analysis draws the questionable conclusion that some of the toughest data sets in empirical asset pricing can be rationalized by the representative investor maximizing an S-shaped utility function, consistent with the so-called Prospect Stochastic Dominance criterion. Further research could be directed to developing global optimization algorithms and consistent re-sampling methods for statistical inference for general risky choice problems.