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Do comorbidities and triggers expedite chronicity in migraine?
(Wolters Kluwer Medknow Publications, 2023) Özçelik, Emel Ur; Karaci, Rahsan; Domac, Fuesun Mayda; Iskender, Mustafa; Ozge, Aynur; Uluduz, Derya; ; School of Medicine;
Background and Aim: Several factors are suggested to be associated with an increased risk of transforming from episodic migraine (EM) to chronic migraine (CM). We aimed to examine whether some specific attack triggers and comorbidities were associated with CM. Methods: Patients followed up with a diagnosis of definite migraine for at least 1 year were divided into two groups, EM (<15 attacks per month) and CM (>15 attacks per month). The demographic and clinical data, attack-triggering factors, and comorbid diseases were compared between the groups. Results: A total of 403 (286 females) patients were analyzed; 227 (56.3%) of the migraineurs had EM and 176 (43.7%) had CM. The mean age was 40.9 +/- 11.3 years in EM, and 42.2 +/- 11.7 years in CM. Disease duration was longer in CM compared with EM (P = 0.007). Missing meals (P = 0.044), exposure to heavy scents/perfumes (P = 0.012), intense physical activity (P = 0.037), and withdrawal of caffeine (P = 0.012) were reported significantly higher in CM than in EM. Comorbid history of medication overuse (P < 0.001), hypertension (P = 0.048), hyperlipidemia (P = 0.025), depression (P = 0.021), chronic painful health problems (P = 0.003), iron deficiency anemia (P = 0.006), and history of surgery (P = 0.006) were found significantly high in CM. Conclusion: This study demonstrates that attack-triggering factors, vascular comorbidities, depression, medication overuse, and chronic painful health problems pose significant risks for CM. Vascular comorbidities are independent risk factors for chronification in migraine and might increase the patient's lifetime morbidity and mortality. Therefore, prompt diagnosis of migraine before the transformation to chronicity and effective early management have the utmost importance.
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The effectiveness of organic vegetable oils with high biocompatibility in preventing epidural fibrosis: an experimental study
(Lifetime Media Ltd, 2023) Akgül, Mehmet Hüseyin; Anteplioğlu, Tuğçe; Kul, Oğuz; Akgün, Mehmet Yiğit; ; Koç University Hospital
Background and purpose – Epidural fibrosis after all spinal surgeries is an important surgical issue. Various biological and non-biological materials have been tried to inhibit epidural fibrosis, which is deemed to be the most important cause of pain after spinal surgery. Olive oil, nigella sativa oil and soybean oil employed in oral nutrition in clinics involving liquid fatty acids, palmatic acid, linoleic acid, stearic acid and palmitoleic acid. The effectiveness of olive oil, nigella sativa oil and soybean oil on epidural fibrosis was researched on for the first time in laminectomy model. Methods – Fifty adult male Wistar albino rats weighing between 300 and 400 grams were used in the research. A total of 5 groups were formed: sham (Group I) (n = 10), no application was created;Group II (n = 10) 1 cc saline;Group III (n = 10) 1 cc olive oil;Group IV (n = 10) 1 cc nigella sativa oil;Group V (n = 10);1 cc soybean oil was applied topically to the epidural region after laminectomy. The total spine of the rats was dissected, histopathological and immunochemical measurements were conducted. Neuro-histopathological results were scored semi-quantitatively in terms of vascular modification, neuron degeneration, gliosis and bleeding criteria. Results – The lowest level of fibrosis and connective tissue proliferation was observed in the group where nigella sativa oil was used after the operation, followed by the group treated with olive oil and lastly with the group given soybean oil. Conclusion – Nigella sativa oil and olive oil are very efficient for lowering the degree of epidural fibrosis and adhesions following laminectomy and can be employed as a simple, inexpensive and highly biocompatible material in clinical practice. © 2023 Ifjusagi Lap-es Konyvkiado Vallalat. All rights reserved.
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Reliability and validity of the Turkish version of the 39-item parkinson disease questionnaire
(Literatura Medica, 2023) Dereli, Elif Elçin; Kayapınar Aylak, Emine Eda; Bilge, Tuba Kayapınar; Çakmak, Özgür Öztop; Ertan, Fatoş Sibel; Taşkıran, Özden Özyemişçi; ; School of Medicine; Koç University Hospital
Background and purpose - This study aims to investigate the validity and reliability of the Turkish Version of the 39-item Parkinson Disease Questionnaire. Methods - A total of 100 patients with Parkinson's disease who were admitted to the outpatient neurology clinic in Koc University and Istanbul University were enrolled. 39-item Parkinson Disease Questionnaire, Parkinson Disease Quality of Life Questionnaire, Unified Parkinson's Disease Rating Scale, Hoehn-Yahr Scale, and Short Form Health Survey-36 were administered to all participants. 39-item Parkinson Disease Questionnaire was repeated 2 weeks later. Results - The internal consistency coefficient of the 39-item Parkinson Disease Questionnaire was 0.957. Test-retest correlation ranged between r = 0.693-0.979. Reliability of Turkish version of the 39-item Parkinson Disease Questionnaire was found to be very high with the exclusion of one item (30(th) item). The scale was found to be consistent over time and correlated positively with Hoehn-Yahr Scale, and negatively with Unified Parkinson's Disease Rating Scale, Parkinson Disease Quality of Life Questionnaire, and Short Form Health Survey-36. Conclusion - Turkish version of the 39-item Parkinson Disease Questionnaire, with the exclusion of the 30th item can be used reliably in assessing the quality of life of Parkinson's patients.

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