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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only The predictive power of coping strategies of pediatric oncology patients on their quality of life and their attitudes toward diseases(Wiley, 2024) Uysal, Gulzade; Alki, Kubra; Semerci, Remziye; Umaç, Eyşan Hanzade; ; School of Nursing; Graduate School of Health Sciences;Background/objectives Pediatric oncology patients face several physical and psychological challenges that can significantly impact their quality of life (QoL) and attitudes toward their illness. Coping strategies are pivotal in managing the emotional and physical burdens of disease. This study aimed to examine the impact of coping strategies of pediatric oncology patients on their QoL and attitudes towards their illness. Design/methods The descriptive, correlational, and cross-sectional study was conducted with 112 pediatric oncology patients aged 10-18 years. The Sociodemographic Form, Pediatric Cancer Coping Scale (PCCS), Pediatric Quality of Life Inventory (PedsQL), and Child Attitude Towards Illness Scale (CATIS) were used for data collection. Results Significant correlations were identified between cognitive coping, defensive coping, and CATIS (p < .001). The PCCS and subdimensions significantly predicted CATIS (p < .001), accounting for 15.3% of the cognitive and defensive coping variation. However, there was no relationship between PCCS total and subdimension scores on PedsQL (p = .534). The PedsQL and subdimensions significantly predicted CATIS (p < .001) and accounted for 27.2% of the variation in physical health summary score, emotional functioning, psychosocial health summary score, and total PedsQL score. Conclusion The study reveals that cognitive coping strategies positively predict attitudes toward illness, whereas defensive coping strategies have an inverse effect. The study proposes that comprehensive care models in pediatric oncology support effective coping mechanisms and enhance the QoL of those who receive them.Publication Metadata only The quality and content analysis of YouTube videos about chemotherapy for children(Wiley, 2024) Semerci, Remziye; Şimşek, Enes; Orhan, Eda; Erbey, Mehmet Fatih; ; School of Nursing; Graduate School of Health Sciences; School of Medicine;Purpose: This study undertook a systematic examination of YouTube videos about chemotherapy for pediatric patients, with a primary focus on assessing the videos' quality, content, and reliability.Method: The research was conducted by searching YouTube using the keywords "chemotherapy for children" and "chemotherapy for pediatric," employing filters for "worldwide" and "all categories." The top 100 videos, based on popularity, were selected for evaluation according to the power analysis calculation. Two independent experts in pediatric oncology reviewed these videos. Video characteristics were recorded: length, view count, likes, dislikes, view ratio, and video-like ratio. The Video Power Index was calculated to measure video popularity. The modified DISCERN and Global Quality Scale (GQS) assessed the videos for quality and reliability.Results: The 100 videos were analyzed. Official health institutions uploaded 54%, while independent users contributed 46%. Independent user uploads garnered significantly more views than official health institutions (p = .006). The number of likes, view ratio, and Video Power Index of independent users' videos were significantly higher than official health institutions' videos (respectively, p = .007, .007, and .008). On the other hand, the modified DISCERN score and GQS were significantly higher in YouTube videos of official health institutions than in independent users (p < .001). A strong correlation was observed between the modified DISCERN score and GQS (r = .879, p < .001).Conclusion: This study provides valuable insights into the YouTube videos on pediatric chemotherapy, emphasizing the need to improve the quality and reliability of online health information for this vulnerable population.Publication Metadata only Virtual reality to improve cancer patients' quality of life: a systematic review(Oncology Nursing Soc, 2023) Aydin, Aydanur; Bağçivan, Gülcan; Özkan, Aleyna; ; School of Nursing; Graduate School of Health Sciences;Quality of life (QoL) encompasses important elements of a patients emotional, social, and physical well being. Cancer patients face psychological issues such as stress, anxiety, and depression, as well as physiological side effects such as hair loss, pain, tiredness, nausea, and vomiting, as well as social issues such as social isolation, role, and function loss, and, eventually, this worsened their quality of life. These issues cause the deterioration in the QoL of cancer...Publication Metadata only Editorial expression of concern: generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization(Springer Nature, 2024) Esai Selvan, Myvizhi; Bhere, Deepak; Shah, Khalid.; Cingöz, Ahmet; Özyerli, Ezgi; Gümüş, Zeynep Hülya; Solaroğlu, İhsan; Önder, Tuğba Bağcı; Morova, Tunç; Şeker-Polat, Fidan; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Sciences and Engineering; School of Medicine;Editorial Expression of Concern to: Oncogenehttps://doi.org/10.1038/s41388-021-01697-6, published online 25 March 2021 The Editors-in-Chief would like to alert the readers that concerns have been raised regarding some of the figures presented in this article [1]. Specifically: The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The authors have provided the raw data pertaining to Figs. 4A, 4F and 6B and stated that the errors in the panels in question occurred during manuscript preparation inadvertently. The conclusions of these figures remain unchanged. However, the original images for Fig. 6E are no longer available. Readers are therefore advised to interpret these results with caution. All authors agree to this Editorial Expression of Concern. © Springer Nature Limited 2024.Publication Metadata only Comparative analysis of autophagy in drug responses and aggressive behavior of adult versus pediatric glioma cell lines(Oxford Univ Press Inc, 2023) ; Yenidoğan, İrem; ; School of Medicine;Abstract Central nervous system tumors are the most common solid cancer and a leading cause of cancer-related deaths in children. Glioma is the most challenging pediatric CNS tumor with therapy resistance and poor prognosis in pediatric patients. Although histopathological analyses revealed similarities with adult brain glioma, emerging evidence suggests that the deregulated molecular pathways in pediatric glioma (p-GM) are different from that of adults. Autophagy, a cellular clearance system and a drug resistance mechanism, has been implicated in glioma progression, invasion, and relapse, yet its role in pediatric patients is not well documented. In this study, we compared the autophagic capacity of adult versus p-GM cell lines and evaluated the effect of autophagy manipulation on drug responses. In addition, migration, extracellular matrix invasion ability, and the metabolism of pediatric and adult gliomas were compared and the contribution of autophagy to the aggressive phenotype was evaluated.Publication Metadata only Risk of new tumor, carotid stenosis, and stroke after stereotactic radiosurgery for pituitary tumor: a multicenter study of 2254 patients with imaging follow-up(Oxford Univ Press, 2024) Dumot, C.; Mantziaris, G.; Dayawansa, S.; Brantley, C.; Lee, C. C.; Yang, H. C.; Mathieu, D.; Tourigny, J. N.; Moreno, N. M.; Álvarez, R. M.; Chytka, T.; Liscák, R.; Speckter, H.; Lazo, E.; Brito, A.; Picozzi, P.; Franzini, A.; Alzate, J.; Mashiach, E.; Bernstein, K.; Kondziolka, D.; Tripathi, M.; Bowden, G. N.; Warnick, R. E.; Sheehan, D.; Sheehan, K.; Fuentes, A.; Jane, J. A. Jr.; Lee Vance, M.; Sheehan, J. P.; Peker, Selçuk; Samancı, Mustafa Yavuz; ; School of Medicine;Background A higher risk of secondary brain tumor, carotid stenosis, and stroke has been reported after conventional sella irradiation for pituitary neuroendocrine tumors (PitNET). Stereotactic radiosurgery (SRS), which is a more focused approach, is now increasingly used instead. The aim was to assess the risk of secondary brain tumor, carotid stenosis/occlusion, and stroke after SRS. Methods In this multicentric retrospective study, 2254 patients with PitNET were studied, 1377 in the exposed group, and 877 in the control group. Results There were 9840.1 patient-years at risk for the SRS and 5266.5 for the control group. The 15-year cumulative probability of secondary intracranial tumor was 2.3% (95% CI: 0.5%, 4.1%) for SRS and 3.7% (95% CI: 0%, 8.7%) for the control group (P = .6), with an incidence rate of 1.32 per 1000 and 0.95 per 1000, respectively. SRS was not associated with an increased risk of tumorigenesis when stratified by age (HR: 1.59 [95% CI: 0.57, 4.47], Pp = .38). The 15-year probability of new carotid stenosis/occlusion was 0.9% (95% CI: 0.2, 1.6) in the SRS and 2% (95% CI: 0, 4.4) in the control group (P = .8). The 15-year probability of stroke was 2.6% (95% CI: 0.6%, 4.6%) in the SRS and 11.1% (95% CI: 6%, 15.9%) in the control group (P < .001). In Cox multivariate analysis stratified by age, SRS (HR 1.85 [95% CI:0.64, 5.35], P = .26) was not associated with risk of new stroke. Conclusions No increased risk of long-term secondary brain tumor, new stenosis or occlusion, and stroke was demonstrated in the SRS group compared to the control in this study with imaging surveillance.