Publications without Fulltext

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3

Browse

Filters

2016 - 20184

Advanced Search

Filter by

Settings

Department: search.filters.department.Department of Industrial EngineeringSubject: search.filters.subject.Oncology

Search Results

Now showing 1 - 4 of 4
  • Placeholder
    PublicationMetadata only
    Identification of novel molecular players of GBM cell dispersal through an in vitro profiling approach
    (Oxford Univ Press, 2016) Gümüş, Zeynep Hülya; N/A; N/A; N/A; N/A; Department of Industrial Engineering; N/A; Şeker-Polat, Fidan; Erkent, Mahmut Alp; Ergüder, Nazlı; Sevinç, Kenan; Gönen, Mehmet; Önder, Tuğba Bağcı; Phd Student; Undergraduate Student; Undergraduate Student; Phd Student; Faculty Member; Faculty Member; Department of Industrial Engineering; Graduate School of Health Sciences; School of Medicine; School of Medicine; Graduate School of Sciences and Engineering; College of Engineering; School of Medicine; N/A; N/A; N/A; N/A; 237468; 184359
    Glioblastoma multiforme (GBM) is the most common and aggressive type of gliomas with a mean survival of 1 year after diagnosis. A major obstacle in treating GBMs is extensive tumor cell infiltration into the surrounding brain. Despite tumor resection and combined therapy, recurrence occurs in the vicinity of the resection margin due to individual cells that dispersed out of the primary tumor, therefore; developing novel therapies that target tumor cell dispersal is of high priority. The goal of this project is to identify genes that are differentially regulated during GBM cell dispersal and to validate their function in in vitro models of dispersal. In this project, we have used an in vitro model of cell motility whereby the dynamics of GBM cell dispersal can be monitored in real-time and quantitated. Accordingly, we isolated motile/migratory/dispersive cells from non-motile/core cells and used these cells for investigating the genes that are differentially regulated during different phases of cell movement by using RNA sequencing. Analysis of the sequencing experiments showed the presence of many differentially expressed genes in motile vs non-motile cells. Most of the genes that have the highest expression in motile cells compared to non-motile ones were linked to epithelial to mesenchymal transition and cell motility based on our pathway and gene set enrichment analyses. Our current focus is on five different candidate genes: CTGF, CYR61, SERPINE1, INHBA and PTX3. Among these, the expression of SERPINE1, a serine protease inhibitor, had predictive value for overall survival of gliomas and therefore is an interesting therapeutic candidate. Currently, we are conducting loss-of-function and gain-of function experiments targeting these genes. Together, these studies have the potential to discover novel molecular players of GBM cell dispersal and open up new avenues for designing new therapeutic strategies against the invasive phenotype of otherwise untreatable malignant GBMs.
  • Placeholder
    PublicationMetadata only
    Comprehensive analysis of miRNA-mRNA regulatory modules and their association with survival in diffuse lower grade gliomas
    (2016) Tihan, Tarık; Keleş, Güven Evren; Department of Industrial Engineering; N/A; Gönen, Mehmet; Solaroğlu, İhsan; Faculty Member; Faculty Member; Department of Industrial Engineering; College of Engineering; School of Medicine; Koç University Hospital; 237468; 102059
    N/A
  • Placeholder
    PublicationMetadata only
    Profiling of different GBM cell populations with varying apoptotic thresholds identifies IGFBP-2 as a novel mediator of trail resistance
    (Oxford Univ Press Inc, 2016) Gümüş, Zeynep Hülya; N/A; Department of Industrial Engineering; N/A; Cingöz, Ahmet; Gönen, Mehmet; Önder, Tuğba Bağcı; Researcher; Faculty Member; Faculty Member; Department of Industrial Engineering; Graduate School of Health Sciences / Animal Laboratory; College of Engineering; School of Medicine; N/A; 237468; 184359
    N/A
  • Placeholder
    PublicationMetadata only
    Androgen receptor binding sites are highly mutated in prostate cancer
    (American Association for Cancer Research (AACR), 2018) N/A; Department of Industrial Engineering; Department of Computer Engineering; Department of Chemical and Biological Engineering; N/A; Morova, Tunç; Gönen, Mehmet; Gürsoy, Attila; Keskin, Özlem; Lack, Nathan Alan; N/A; Faculty Member; Faculty Member; Faculty Member; Faculty Member; Department of Industrial Engineering; Department of Computer Engineering; Department of Chemical and Biological Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; College of Engineering; College of Engineering; College of Engineering; School of Medicine; N/A; 237468; 8745; 26605; 120842