Publications without Fulltext
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
Browse
4980 results
Filters
Advanced Search
Filter by
Settings
Search Results
Publication Metadata only Discrepancy between IDSA and ESGBOR in Lyme disease: individual participant meta-analysis in Türkiye(Wiley, 2024) N/A; Yıldız, Abdullah Burak; Çetin, Ecesu; Pınarlık, Fatihan; Keske, Şiran; Can, Füsun; Ergönül, Önder; Koç University İşbank Center for Infectious Diseases (KU-IS CID); School of Medicine; Graduate School of Health SciencesBackground: The evidence on the prevalence of Lyme borreliosis (LB) is limited, but there is a suspicion of overdiagnosis of LB in recent years. We reviewed the LB diagnosis and treatment-related data in Turkiye, based on the Infectious Diseases Society of America (IDSA) 2020 and European Society of Clinical Microbiology and Infectious Diseases Study Group for Lyme Borreliosis (ESGBOR) 2018 guidelines. By detecting the disagreements between these two, we outlined the areas to be improved for future guidelines. Methods: We performed a literature search according to the PRISMA guidelines in PubMed, Ovid-Medline, Web of Science, Turkish Medline, Scopus, CINAHL, ULAKBIM TR Index, Google Scholar and Cochrane Library databases. We included the published cases in a database and evaluated according to IDSA and ESGBOR guidelines. We outlined the reasons for misdiagnoses and inappropriate uses of antibiotics. Results: We included 42 relevant studies with 84 LB cases reported from Turkiye between 1990 and December 2022. Among 84 cases, the most common clinical findings were nervous system findings (n = 37, 44.0%), erythema migrans (n = 29, 34.5%) and ophthalmologic findings (n = 15, 17.9%). The IDSA 2020 and ESGBOR 2018 guidelines agreed on the diagnosis of 71 (84.5%) cases; there was an agreement that 31 cases (36.9%) were misdiagnosed and 40 cases (47.6%) were correctly diagnosed, and there was disagreement for 13 cases (15.5%). Serum immunoglobulin M (IgM), IgG measurements by ELISA and western blot were widely performed, and they were effective in definitive diagnosis merely when used according to guidelines. Inappropriate use of antibiotics was detected in 42 (50.0%) of cases which were classified in the following categories: incorrect LB diagnosis, inappropriate choice of antibiotic, inappropriate route of drug administration and prolonged antibiotic treatment. Conclusion: Overdiagnosis and non-adherence to guidelines is a common problem. The discordance between seroprevalence and clinical studies necessitates a consensus over the best clinical approach.Publication Metadata only Investigation of nursing students' knowledge levels and attitudes in incontinence-associated dermatitis management through game-based learning: a mixed methods study(HMP, 2024) Kaya, Nurten; Kirkland-Kyhn, Holly; N/A; Şengül, Tuba; Akyaz, Dilek Yılmaz; Cevizci, Tuğba; Oldaç, Tuğçe; Koyun, Hamza Can; School of Nursing; Koç University HospitalPURPOSE: This study aimed to assess nursing students' knowledge levels and attitudes towards the etiology, risk factors, and preventive measures of incontinence-associated dermatitis (IAD) using an escape room game. DESIGN: A mixed-method study. SUBJECTS AND SETTING: The sample size of the study was 32 students. METHODS: Quantitative data obtained with the Knowledge, Attitude and Practice of Nurses in Managing Incontinence-Associated Dermatitis Questionnaire (KAP-IAD-Q) and qualitative data obtained through FGDs following the Consolidated Criteria for Reporting Qualitative Research (COREQ) checklist were analyzed using a thematic approach. RESULTS: The average age of the participants was 22.63 +/- 0.90, 87.5% of them were female (n=28), and 50% were third (n=16) and fourth-year students (n=16). KAP-IAD-Q total posttest score (88.06+7.00) was found to be high. Data obtained from the FGDs were categorized under 3 main themes: main focus areas during participation in the IAD-themed escape room game; advantages and disadvantages of teamwork in IAD management; and the game's contribution to a better understanding and classification of IAD. CONCLUSIONS: The use of the escape room game facilitated high, fast, and efficient learning of IAD knowledge and attitudes. It revealed challenges in collaborative decision-making, accurate diagnosis, distinguishing from other wounds, and attitude development in the management of IAD.Publication Metadata only The role of PSMA PET/CT in predicting downgrading in patients with Gleason score 4+4 prostate cancer in prostate biopsy(Springer, 2024) N/A; Aykanat, İbrahim Can; Kordan, Yakup; Seymen, Hülya; Köseoğlu, Ersin; Özkan, Arif; Esen, Barış; Tarım, Kayhan; Kulaç, İbrahim; Falay, Fikri Okan; Gürses, Bengi; Baydar, Dilek Ertoy; Canda, Abdullah Erdem; Balbay, Mevlana Derya; Demirkol, Mehmet Onur; Esen, Tarık; School of Medicine; Koç University HospitalBackground To investigate the predictable parameters associated with downgrading in patients with a Gleason score (GS) 8 (4+4) in prostate biopsy after radical prostatectomy. Methods We retrospectively analyzed 62 patients with a GS of 4+4 on prostate biopsy who underwent robotic radical prostatectomy between 2017 and 2022. Results 38 of 62 (61.2%) were downgraded. In multivariable logistic regression model, Ga-68 prostate-specific membrane antigen (PSMA) positron-emission tomography (PET)/computed tomography (CT) SUV max was independent predictor of downgrading (OR 0.904; p = 0.011) and a Logistic Regression model was constructed using the following formula: Y = 1.465-0.95 (PSMA PET/CT SUV max). The model using this variable correctly predicted the downgrading in 72.6% of patients. The AUC for PSMA PET/CT SUV max was 0.709 the cut off being 8.8. A subgroup analysis was performed in 37 patients who had no other European Association of Urology (EAU) high risk features. 25 out of 37 (67.5%) were downgraded, and 21 of these 25 had organ confined disease. Low PSMA SUV max (<8.1) and percentage of GS 4+4 biopsy cores to cancer bearing cores (45.0%) were independently associated with downgrading to GS 7. Conclusion PSMA PET/CT can be used to predict downgrading in patients with GS 4+4 PCa. Patients with GS 4+4 disease, but no other EAU high risk features, low percentage of GS 4+4 biopsy cores to cancer bearing cores, and a low PSMA PET/CT SUV max are associated with a high likelihood of the cancer reclassification to intermediate risk group.Publication Metadata only Anatomical parameters of percutaneous, minimally invasive, direct intralaminar pars screw fixation of spondylolysis(Elsevier Science Inc, 2024) Gudu, Burhan Oral; Aydin, Ahmet Levent; Mercan, Necip Engin; Dilbaz, Suna; Cirak, Musa; N/A; Özer, Ali Fahir; School of Medicine- OBJECTIVE: To investigate the anatomical parameters of the ideal screw trajectory for percutaneous intralaminar screw fixation of a pars defect in lumbar spondylolysis using computed tomography scans. - METHODS: Using advanced radiological software, the ideal intralaminar screw trajectory was determined. The anatomical parameters of this trajectory were analyzed using a total of 80 single-level lumbar tomography scans in patients with spondylolysis at the lumbar 4 vertebrae and lumbar 5 vertebrae levels. The ideal intralaminar screw trajectory started from the inferolateral edge of the lamina and was between the intralaminar region, pars defect, and defective pars neck and pedicle. Along this trajectory, the skin-lamina distance, intralaminar screw length, isthmic lamina length and width, defective pars neck width, lateral entry distance of the screw to the center of the spinous process, and sagittal and coronal screw application angles were analyzed. - RESULTS: When comparing the lumbar 4 vertebrae and lumbar 5 vertebrae parameters, the mean skin-to-lamina distances were 11-9 cm ( P = 0.000), intralaminar screw lengths 3.5-3.6 cm ( P = 0.067), isthmic lamina lengths 22 cm ( P = 0.698), mid-lamina widths 1-1 cm ( P = 0.941), defective pars neck widths 1-1 cm ( P = 0.674), screw lateral entry distances according to the spinous process 1-1.5 cm ( P = 0.000), sagittal screw angles 45 degrees-45 degrees ( P = 0.870), and coronal screw angles 10 degrees-20 degrees ( P = 0.000), respectively. There were no differences based on age and gender ( P < 0.05). - CONCLUSIONS: Percutaneous intralaminar rigid screw fixation of a pars defect in spondylolysis provides minimally invasive, low-profile instrumentation. In spondylolysis, a screw length of 3-4 cm and a screw diameter of 45 mm may be sufficient for pars fixation with intralaminar screws.Publication Metadata only Association of TaqI (rs731236) polymorphism of vitamin D receptor gene with lumbar degenerative disc disease(Elsevier Science Inc, 2024) Serifoglu, Luay; Yilmaz, Seda Gulec; Karaaslanli, Abdulmutalip; Etli, Mustafa Umut; Ozdogan, Selcuk; N/A; Düzkalır, Ali Haluk; N/A; Koç University Hospital- BACKGROUND: Lumbar degenerative disc disease (LDDD) significantly contributes to low back pain, with a complicated etiology involving genetic and environmental facts. The aim of study was to investigate the association between the Taq I (rs731236) polymorphism of the vitamin D receptor ( VDR ) gene with LDDD. - METHODS: In total, 248 patients with symptomatic LDDD and 146 control subjects were examined. The evaluation of clinical features of patients with LDDD comprised radiodiagnostic magnetic resonance imaging, neurologic examinations, pain scores including the visual analog scale (VAS), and disability investigation with Oswestry Disability Index (ODI). Genotyping of the VDR gene polymorphism was conducted using polymerase chain reaction ebased methods.- RESULTS: Individuals of the LDDD group who were VDR TaqI AA genotype carriers were significantly greater than the other group ( P = 0.014), whereas those with GG genotype were significantly lower ( P = 0.028) in the patient group. In addition, VAS and ODI scores were significantly lower in the GG genotype carrier group, whereas AA genotype carriers had the greatest scores ( P = 0.004). Carrying the G allele decreased the risk of LDDD 1.7 times ( P = 0.014) and carrying the A allele enhanced the risk 1.8 times ( P = 0.028). Moreover, G-allele carriers had significantly lower VAS ( P = 0.002) and ODI scores ( P < 0.0001). - CONCLUSIONS: VDR Taq I (rs731236) GG genotype and G allele have protective potential, whereas the AA genotype and A allele are risk factors for LDDD. The findings reveal a statistically significant association of the Taq I (rs731236) polymorphism of VDR gene polymorphism with LDDD. This result highlights the potential role of genetic factors in developing LDDD and suggests avenues for future research in genetic screening and personalized treatment strategies.Publication Metadata only Chitosan in cancer therapy: a dual role as a therapeutic agent and drug delivery system(Walter de Gruyter Gmbh, 2024) Atmaca, Harika; Ilhan, Suleyman; N/A; Oğuz, Ferdi; Graduate School of Health SciencesAlthough chemotherapy is still the most preferred treatment for cancer, most chemotherapeutic agents target both cancer cells and healthy cells and cause serious side effects due to high toxicity. Improved drug delivery systems (DDSs), which enhance the efficacy of current chemotherapeutic drugs while reducing their toxicity, offer potential solutions to these challenges. Chitosan (CS) and its derivatives are biopolymers with biodegradable, biocompatible, and low-toxicity properties, and their structure allows for convenient chemical and mechanical modifications. In its role as a therapeutic agent, CS can impede the proliferation of tumor cells through the inhibition of angiogenesis and metastasis, as well as by triggering apoptosis. CS and its derivatives are also frequently preferred as DDSs due to their properties such as high drug-carrying capacity, polycationic structure, long-term circulation, and direct targeting of cancer cells. Various therapeutic agents linked to CS and its derivatives demonstrate potent anticancer effects with advantages such as reduced side effects compared to the original drugs, owing to factors like targeted distribution within cancer tissues and sustained release. This review emphasizes the utilization of CS and its derivatives, both as therapeutic agents and as carriers for established chemotherapeutic drugs.Publication Metadata only The relationship between inflammatory processes and apoptosis in lumbar disc degeneration(Elsevier Inc., 2024) Cetintas, Semih Can; Akyol, Sibel; Alizada, Orkhan; Tahmazoglu, Burak; Hanci, Murat; Isler, Cihan; N/A; Akgün, Mehmet Yiğit; N/A; Koç University HospitalObjective: Degenerative Disc Disease (DDD) is a common health problem in the population. There are recent studies focusing on relationship between DDD and immunological factors. However, there is still a lack of data on the role of apoptosis in DDD pathophysiology. Therefore, we aimed to investigate the relationship between Modic-type changes and the apoptosis in DDD. Materials and Methods: Ninety adult male patients who presented with low back and/or radicular pain and were operated on due to lumbar disc herniation were included. Three groups were formed based on Modic type degeneration observed on magnetic resonance imaging. Specific parameters involved in the intrinsic and extrinsic pathways of apoptosis were assessed in excised disc materials using the enzyme-linked immunosorbent assay method. Results: All three groups formed according to Modic degeneration types were homogenous in all variances. Cytochrome-C was significantly decreased only in the Modic type-3 group, whereas Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor-1, B-Cell Lymphoma-2 (Bcl-2) Homologous Antagonist Killer-1, Direct Inhibitor of Apoptosis-Binding Protein with Low Pi, and Bcl-2 Associated X Apoptosis Regulator levels were significantly different in both Modic type-2 and -3 groups. However, BH3 interacting domain death agonist and Bcl-2 levels were similar across all groups. Conclusions: In conclusion, this study suggests that Direct Inhibitor of Apoptosis-Binding Protein with Low Pi, cytochrome - c, Bcl-2 Associated X Apoptosis Regulator, Bcl-2 Homologous Antagonist Killer-1, and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor-1proteins play important roles in the development and progression of DDD and are correlated with Modic types. Further studies are needed to explore the potential therapeutic role of inhibiting these apoptotic proteins in DDD. © 2024 Elsevier Inc.Publication Metadata only Survival benefit of nephroureterectomy in systemic therapy exposed metastatic upper tract urinary urothelial carcinoma patients(Springer, 2024) Morra, Simone; Incesu, Reha-Baris; Scheipner, Lukas; Baudo, Andrea; Jannello, Letizia Maria Ippolita; Siech, Carolin; de Angelis, Mario; Tian, Zhe; Creta, Massimiliano; Califano, Gianluigi; Colla Ruvolo, Claudia; Saad, Fred; Shariat, Shahrokh F.; Chun, Felix K. H.; de Cobelli, Ottavio; Musi, Gennaro; Briganti, Alberto; Ahyai, Sascha; Carmignani, Luca; Longo, Nicola; Karakiewicz, Pierre I.; N/A; Tilki, Derya; School of MedicineBackground It is unknown whether the stage of the primary may influence the survival (OS) of metastatic upper tract urothelial carcinoma (mUTUC) patients treated with nephroureterectomy (NU) and systemic therapy (ST). We tested this hypothesis within a large-scale North American cohort. Methods Within Surveillance Epidemiology and End Results database 2000-2020, all mUTUC patients treated with ST+NU or with ST alone were identified. Kaplan-Maier plots depicted OS. Multivariable Cox regression (MCR) models tested for differences between ST+NU and ST alone predicting overall mortality (OM). All analyses were performed in localized (T1-T2) and then repeated in locally advanced (T3-T4) patients. Results Of all 728 mUTUC patients, 187 (26%) harbored T1-T2 vs 541 (74%) harbored T3-T4. In T1-T2 patients, the median OS was 20 months in ST+NU vs 10 months in ST alone. Moreover, in MCR analyses that also relied on 3 months' landmark analyses, the combination of ST+NU independently predicted lower OM (HR 0.37, p < 0.001). Conversely, in T3-T4 patients, the median OS was 12 in ST+NU vs 10 months in ST alone. Moreover, in MCR analyses that also relied on 3 months' landmark analyses, the combination of ST+NU was not independently associated with lower OM (HR 0.85, p = 0.1). Conclusions In mUTUC patients, treated with ST, NU drastically improved survival in T1-T2 patients, even after strict methodological adjustments (multivariable and landmark analyses). However, this survival benefit did not apply to patients with locally more advanced disease (T3-T4).Publication Metadata only Goodbye Hartmann trial: a prospective, international, multicenter, observational study on the current use of a surgical procedure developed a century ago(BMC, 2024) Perrone, Gennaro; Giuffrida, Mario; Abu-Zidan, Fikri; Kruger, Vitor F.; Livrini, Marco; Petracca, Gabriele Luciano; Rossi, Giorgio; Tarasconi, Antonio; Tian, Brian W. C. A.; Bonati, Elena; Mentz, Ricardo; Mazzini, Federico N.; Campana, Juan P.; Gasser, Elisabeth; Kafka-Ritsch, Reinhold; Felsenreich, Daniel M.; Dawoud, Christopher; Riss, Stefan; Gomes, Carlos Augusto; Gomes, Felipe Couto; Teixeira Gonzaga, Ricardo Alessandro; Brattig Canton, Cassio Alfred; Pereira, Bruno Monteiro; Fraga, Gustavo P.; Zem, Leticia Goncalves; Cordeiro-Fonseca, Vinicius; Tauil, Renato de Mesquita; Atanasov, Boyko; Belev, Nikolay; Kovachev, Nikola; Melendez, L. Juan Jose; Dimova, Ana; Dimov, Stefan; Zelic, Zdravko; Augustin, Goran; Bogdanic, Branko; Moric, Trpimir; Chouillard, Elie; Bajul, Melinda; De Simone, Belinda; Panis, Yves; Esposito, Francesco; Notarnicola, Margherita; Lauka, Lelde; Fabbri, Anna; Hentati, Hassen; Fnaiech, Iskander; Aurelien, Venara; Bougard, Marie; Roulet, Maxime; Demetrashvili, Zaza; Pipia, Irakli; Merabishvili, Giorgi; Bouliaris, Konstantinos; Koukoulis, Georgios; Doudakmanis, Christos; Xenaki, Sofia; Chrysos, Emmanuel; Kokkinakis, Stamatios; Vassiliu, Panteleimon; Michalopoulos, Nikolaos; Margaris, Ioannis; Kechagias, Aristotelis; Avgerinos, Konstantinos; Katunin, Jevgeni; Lostoridis, Eftychios; Nagorni, Eleni-Aikaterini; Pujante, Antonio; Mulita, Francesk; Maroulis, Ioannis; Vailas, Michail; Marinis, Athanasios; Siannis, Ioannis; Bourbouteli, Eirini; Manatakis, Dimitrios K.; Tasis, Nikolaos; Acheimastos, Vasileios; Maria, Sotiropoulou; Stylianos, Kapiris; Kuzeridis, Harilaos; Korkolis, Dimitrios; Fradelos, Evangelos; Kavalieratos, George; Petropoulou, Thalia; Polydorou, Andreas; Papacostantinou, Ioannis; Triantafyllou, Tania; Kimpizi, Despina; Theodorou, Dimitrios; Toutouzas, Konstantinos; Chamzin, Alexandros; Frountzas, Maximos; Schizas, Dimitrios; Karavokyros, Ioannis; Syllaios, Athanasios; Charalabopoulos, Alexandros; Boura, Maria; Baili, Efstratia; Ioannidis, Orestis; Loutzidou, Lydia; Anestiadou, Elissavet; Tsouknidas, Ioannis; Petrakis, Georgios; Polenta, Eleni; Bains, Lovenish; Gupta, Rahul; Singh, Sudhir K.; Khanduri, Archana; Bala, Miklosh; Kedar, Asaf; Pisano, Marcello; Podda, Mauro; Pisanu, Adolfo; Martines, Gennaro; Trigiante, Giuseppe; Lantone, Giuliano; Agrusa, Antonino; Di Buono, Giuseppe; Buscemi, Salvatore; Veroux, Massimiliano; Gioco, Rossella; Veroux, Gastone; Oragano, Luigi; Zonta, Sandro; Lovisetto, Federico; Feo, Carlo V.; Pesce, Antonio; Fabbri, Nicolo; Lantone, Giulio; Marino, Fabio; Perrone, Fabrizio; Vincenti, Leonardo; Papagni, Vincenzo; Picciariello, Arcangelo; Rossi, Stefano; Picardi, Biagio; Del Monte, Simone Rossi; Visconti, Diego; Osella, Giulia; Petruzzelli, Luca; Pignata, Giusto; Andreuccetti, Jacopo; D'Alessio, Rossella; Buonfantino, Massimo; Guaitoli, Eleonora; Spinelli, Stefano; Sampietro, Gianluca Matteo; Corbellini, Carlo; Lorusso, Leonardo; Frontali, Alice; Pezzoli, Isabella; Bonomi, Alessandro; Chierici, Andrea; Cotsoglou, Christian; Manca, Giuseppe; Delvecchio, Antonella; Musa, Nicola; Casati, Massimiliano; Letizia, Laface; Abate, Emmanuele; Ercolani, Giorgio; D'Acapito, Fabrizio; Solaini, Leonardo; Guercioni, Gianluca; Cicconi, Simone; Sasia, Diego; Borghi, Felice; Giraudo, Giorgio; Sena, Giuseppe; Castaldo, Pasquale; Cardamone, Eugenia; Portale, Giuseppe; Zuin, Matteo; Spolverato, Ylenia; Esposito, Marialusia; Isernia, Roberta Maria; Di Salvo, Maria; Manunza, Romina; Esposito, Giuseppe; Agus, Marcello; Asti, Emanuele Luigi Giuseppe; Bernardi, Daniele Tiziano; Tonucci, Tommaso Panici; Luppi, Davide; Casadei, Massimiliano; Bonilauri, Stefano; Pezzolla, Angela; Panebianco, Annunziata; Laforgia, Rita; De Luca, Maurizio; Zese, Monica; Parini, Dario; Jovine, Elio; De Sario, Giuseppina; Lombardi, Raffaele; Aprea, Giovanni; Palomba, Giuseppe; Capuano, Marianna; Argenio, Giulio; Orio, Gianluca; Armellino, Mariano Fortunato; Troian, Marina; Guerra, Martina; Nagliati, Carlo; Biloslavo, Alan; Germani, Paola; Aizza, Giada; Monsellato, Igor; Chahrour, Ali Chaouki; Anania, Gabriele; Bombardini, Cristina; Bagolini, Francesco; Sganga, Gabriele; Fransvea, Pietro; Bianchi, Valentina; Boati, Paolo; Ferrara, Francesco; Palmieri, Francesco; Cianci, Pasquale; Gattulli, Domenico; Restini, Enrico; Cillara, Nicola; Cannavera, Alessandro; Nita, Gabriela Elisa; Sarnari, Jlenia; Roscio, Francesco; Clerici, Federico; Scandroglio, Ildo; Berti, Stefano; Cadeo, Alessandro; Filippelli, Alice; Conti, Luigi; Grassi, Carmine; Cattaneo, Gaetano Maria; Pighin, Marina; Papis, Davide; Gambino, Giovanni; Bertino, Vanessa; Schifano, Domenico; Prando, Daniela; Fogato, Luisella; Cavallo, Fabio; Ansaloni, Luca; Picheo, Roberto; Pontarolo, Nicholas; Depalma, Norma; Spampinato, Marcello; D'Ugo, Stefano; Lepre, Luca; Capponi, Michela Giulii; Campa, Rossella Domenica; Sarro, Giuliano; Dinuzzi, Vincenza Paola; Olmi, Stefano; Uccelli, Matteo; Ferrari, Davide; Inama, Marco; Moretto, Gianluigi; Fontana, Michele; Favi, Francesco; Picariello, Erika; Rampini, Alessia; Barberis, Andrea; Azzinnaro, Antonio; Oliva, Alba; Totaro, Luigi; Benzoni, Ilaria; Ranieri, Valerio; Capolupo, Gabriella Teresa; Carannante, Filippo; Caricato, Marco; Ronconi, Maurizio; Casiraghi, Silvia; Casole, Giovanni; Pantalone, Desire; Alemanno, Giovanni; Scheiterle, Maximilian; Ceresoli, Marco; Cereda, Marco; Fumagalli, Chiara; Zanzi, Federico; Bolzon, Stefano; Guerra, Enrico; Lecchi, Francesca; Cellerino, Paola; Ardito, Antonella; Scaramuzzo, Rosa; Balla, Andrea; Lepiane, Pasquale; Tartaglia, Nicola; Ambrosi, Antonio; Pavone, Giovanna; Palini, Gian Marco; Veneroni, Simone; Garulli, Gianluca; Ricci, Claudio; Torre, Beatrice; Russo, Iris Shari; Rottoli, Matteo; Tanzanu, Marta; Belvedere, Angela; Milone, Marco; Manigrasso, Michele; De Palma, Giovanni Domenico; Piccoli, Micaela; Pattacini, Gianmaria Casoni; Magnone, Stefano; Bertoli, Paolo; Pisano, Michele; Massucco, Paolo; Palisi, Marco; Luzzi, Andrea-Pierre; Fleres, Francesco; Clarizia, Guglielmo; Spolini, Alessandro; Kobe, Yoshiro; Toma, Takayuki; Shimamura, Fumihiko; Parker, Robert; Ranketi, Sinkeet; Mitei, Mercy; Svagzdys, Saulius; Pauzas, Henrikas; Zilinskas, Justas; Poskus, Tomas; Kryzauskas, Marius; Jakubauskas, Matas; Zakaria, Andee Dzulkarnaen; Zakaria, Zaidi; Wong, Michael Pak-Kai; Jusoh, Asri Che; Zakaria, Muhammad Nazreen; Cruz, Daniel Rios; Elizalde, Aurea Barbara Rodriguez; Reynaud, Alejandro Banon; Hernandez, Edgard Efren Lozada; Monroy, Jose Maria Victor Palomo; Hinojosa-Ugarte, Diego; Quiodettis, Martha; Du Bois, Maria Esther; Latorraca, Jose; Major, Piotr; Pedziwiatr, Michal; Pisarska-Adamczyk, Magdalena; Waledziak, Maciej; Kwiatkowski, Andrzej; Czyzykowski, Lukasz; da Costa, Silvia Dantas; Pereira, Bela; Ferreira, Ana Rita Oliveira; Almeida, Filipe; Rocha, Ricardo; Carneiro, Carla; Perez, Diego Pita; Carvas, Joao; Rocha, Catarina; Ferreira, Catia; Marques, Rita; Fernandes, Urania; Leao, Pedro; Goulart, Andre; Pereira, Rita Goncalves; Patrocinio, Sara Daniela Direito; de Mendonca, Nuno Goncalo Goncalves; Manso, Maria Isabel Cerqueira; Morais, Henrique Manuel Cardoso; Cardoso, Paulo Sebastiao; Calu, Valentin; Miron, Adrian; Toma, Elena Adelina; Gachabayov, Mahir; Abdullaev, Abakar; Litvin, Andrey; Nechay, Taras; Tyagunov, Alexander; Yuldashev, Anvar; Bradley, Alison; Wilson, Michael; Panyko, Arpad; Lateckova, Zuzana; Lacko, Vladimir; Lesko, Dusan; Soltes, Marek; Radonak, Jozef; Turrado-Rodriguez, Victor; Termes-Serra, Roser; Morales-Sevillano, Xavier; Lapolla, Pierfrancesco; Mingoli, Andrea; Brachini, Gioia; Degiuli, Maurizio; Sofia, Silvia; Reddavid, Rossella; Garberini, Andrea de Manzoni; Buffone, Angelica; del Pozo, Eduardo Perea; Aparicio-Sanchez, Daniel; Dos Barbeito, Sandra; Estaire-Gomez, Mercedes; Viton-Herrero, Rebeca; Gil Olarte-Marquez, Ma de los Angeles; Gil-Martinez, Jose; Alconchel, Felipe; Nicolas-Lopez, Tatiana; Rahy-Martin, Aida Cristina; Pelloni, Maria; Banolas-Suarez, Raquel; Mendoza-Moreno, Fernando; Nisa, Francisca Garcia-Moreno; Diez-Alonso, Manuel; Rodas, Maria Elisa Valle; Agundez, Maria Carmona; Perez Andres, Maria Inmaculada; Lopes Moreira, Claudia Cristina; Lizarazu Perez, Aintzane; Ponce, Inigo Augusto; Gonzalez-Castillo, Ana Maria; Membrilla-Fernandez, Estela; Salvans, Silvia; Serradilla-Martin, Mario; Pardo, Pablo Sancho; Rivera-Alonso, Daniel; Dziakova, Jana; Huguet, Jose Muguerza; Pages Valle, Naila; Colas Ruiz, Enrique; Rey Valcarcel, Cristina; Ruiz Moreno, Cristina; Moreno Salazar, Yeniffer Tatiana; Rubio Garcia, Juan Jesus; Mico, Silvia Sevila; Ruiz Lopez, Joaquin; Perez Farre, Silvia; Santamaria Gomez, Maite; Mestres Petit, Nuria; Titos-Garcia, Alberto; Aranda-Narvaez, Jose Manuel; Romacho-Lopez, Laura; Sanchez-Guillen, Luis; Aranaz-Ostariz, Veronica; Bosch-Ramirez, Marina; Martinez-Perez, Aleix; Martinez-Lopez, Elias; Sebastian-Tomas, Juan Carlos; Jimenez-Riera, Granada; Jimenez-Vega, Javier; Navas Cuellar, Jose Aurelio; Campos-Serra, Andrea; Munoz-Campana, Anna; Gracia-Roman, Raquel; Martinez Alegre, Javier; Lima Pinto, Francisca; O'Sullivan, Sara Nunez; Blanco Antona, Francisco; Munoz Jimenez, Beatriz; Lopez-Sanchez, Jaime; Gomez Carmona, Zahira; Torres Fernandez, Rocio; Blesa Sierra, Isabel; Roman Garcia de Leon, Laura; Polaino Moreno, Veronica; Iglesias, Eva; Lora Cumplido, Paola; Arango Bravo, Altea; Rey Simo, Ignacio; Lopez Dominguez, Carlota; Guerreiro Caamano, Aloia; Calleja Lozano, Rafael; Duran Martinez, Manuel; Naranjo Torres, Alvaro; Morales Bernaldo de Quiros, Javier Tomas; Pellino, Gianluca; Cloquell, Miriam Moratal; Garcia Moller, Elsa; Jalal-Eldin, Sami; Abdoun, Ahmed K.; Hamid, Hytham K. S.; Lohsiriwat, Varut; Mongkhonsupphawan, Aitsariya; Baraket, Oussama; Ayed, Karim; Abbassi, Imed; Ben Ali, Ali; Ammar, Houssem; Kchaou, Ali; Tlili, Ahmed; Zribi, Imen; Colak, Elif; Polat, Suleyman; Koylu, Zehra Alan; Guner, Ali; Usta, Mehmet Arif; Reis, Murat Emre; Mantoglu, Baris; Gonullu, Emre; Akin, Emrah; Altintoprak, Fatih; Bayhan, Zulfu; Firat, Necattin; Isik, Arda; Memis, Ufuk; Bayrak, Mehmet; Altintas, Yasemin; Kara, Yasin; Bozkurt, Mehmet Abdussamet; Kocatas, Ali; Das, Koray; Seker, Ahmet; Ozer, Nazmi; Atici, Semra Demirli; Tuncer, Korhan; Kaya, Tayfun; Ozkan, Zeynep; Ilhan, Onur; Agackiran, Ibrahim; Uzunoglu, Mustafa Yener; Demirbas, Eren; Altinel, Yuksel; Meric, Serhat; Hacim, Nadir Adnan; Tebala, Giovanni D.; Khalil, Hany; Rana, Mridul; Khan, Mansoor; Florence, Charlotte; Swaminathan, Christie; Leo, Cosimo Alex; Liasis, Lampros; Watfah, Josef; Trostchansky, Ivan; Delgado, Edward; Pontillo, Marcelo; Latifi, Rifat; Coimbra, Raul; Edwards, Sara; Lopez, Ana; Velmahos, George; Dorken, Ander; Gebran, Anthony; Palmer, Amanda; Oury, Jeffrey; Bardes, James M.; Seng, Sirivan Suon; Coffua, Lauren S.; Ratnasekera, Asanthi; Egodage, Tanya; Echeverria-Rosario, Karla; Armento, Isabella; Napolitano, Lena M.; Sangji, Naveen F.; Hemmila, Mark; Quick, Jacob A.; Austin, Tyler R.; Hyman, Theodore S.; Curtiss, William; McClure, Amanda; Cairl, Nicholas; Biffl, Walter L.; Truong, Hung P.; Schaffer, Kathryn; Reames, Summer; Banchini, Filippo; Capelli, Patrizio; Coccolini, Federico; Sartelli, Massimo; Bravi, Francesca; Vallicelli, Carlo; Agnoletti, Vanni; Baiocchi, Gian Luca; Catena, Fausto; N/A; Uymaz, Derya Salim; Omarov, Nail; Balık, Emre; School of Medicine; Koç University HospitalBackground: Literature suggests colonic resection and primary anastomosis (RPA) instead of Hartmann's procedure (HP) for the treatment of left-sided colonic emergencies. We aim to evaluate the surgical options globally used to treat patients with acute left-sided colonic emergencies and the factors that leading to the choice of treatment, comparing HP and RPA. Methods: This is a prospective, international, multicenter, observational study registered on ClinicalTrials.gov. A total 1215 patients with left-sided colonic emergencies who required surgery were included from 204 centers during the period of March 1, 2020, to May 31, 2020. with a 1-year follow-up. Results: 564 patients (43.1%) were females. The mean age was 65.9 +/- 15.6 years. HP was performed in 697 (57.3%) patients and RPA in 384 (31.6%) cases. Complicated acute diverticulitis was the most common cause of left-sided colonic emergencies (40.2%), followed by colorectal malignancy (36.6%). Severe complications (Clavien-Dindo >= 3b) were higher in the HP group (P < 0.001). 30-day mortality was higher in HP patients (13.7%), especially in case of bowel perforation and diffused peritonitis. 1-year follow-up showed no differences on ostomy reversal rate between HP and RPA. (P = 0.127). A backward likelihood logistic regression model showed that RPA was preferred in younger patients, having low ASA score (<= 3), in case of large bowel obstruction, absence of colonic ischemia, longer time from admission to surgery, operating early at the day working hours, by a surgeon who performed more than 50 colorectal resections. Conclusions: After 100 years since the first Hartmann's procedure, HP remains the most common treatment for left-sided colorectal emergencies. Treatment's choice depends on patient characteristics, the time of surgery and the experience of the surgeon. RPA should be considered as the gold standard for surgery, with HP being an exception.Publication Metadata only Family disaster: the origins of gender violence legislation in Turkey(Sage Publications Inc, 2024) N/A; Birelma, Ayşe Alnıaçık; The Center for Gender Studies (KOÇ-KAM) / Koç Üniversitesi Toplumsal Cinsiyet ve Kadın Çalışmaları Araştırma ve Uygulama Merkezi (KOÇ-KAM); N/AThis article provides a case study regarding struggles over framing gender violence as a political issue. It looks at how gender violence initially entered political discourse and state legislation in Turkey. It identifies the main political actors as feminists, Islamists, and Kemalists, and examines their impacts on state policy-making processes and outcomes. It argues that, in the Turkish context, the Islamism-Kemalism divide contoured the limits and possibilities of frame institutionalization in legislation and characterized state responses to gender violence through familial ideology, which prioritized family privacy and unity over women's right to live free from violence.