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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Unguales plattenepithelkarzinom bei einem patienten mit mal de meleda(Wiley, 2016) Baykal, Can; Sarı, Şule Öztürk; Uyguner, Zehra Oya; Ekinci, Algun Polat; Demir, Özgür; Babuna, Goncagül; Büyükbabani, Nesimi; N/A; Kayserili, Hülya; Faculty Member; School of Medicine; 7945N/APublication Metadata only Light engine and optics for HELIUM3D auto-stereoscopic laser scanning display(IEEE, 2011) Willman, Eero; Baghsiahi, Hadi; Day, Sally E.; Selviah, David R.; Fernandez, F. Anibal; N/A; Department of Electrical and Electronics Engineering; N/A; Department of Electrical and Electronics Engineering; Department of Electrical and Electronics Engineering; Akşit, Kaan; Ölçer, Selim; Erden, Erdem; Chellappan, Kishore Velichappattu; Ürey, Hakan; PhD Student; Other; Master Student; Researcher; Faculty Member; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Sciences and Engineering; College of Engineering; College of Engineering; N/A; N/A; N/A; N/A; 8579This paper presents a laser-based auto-stereoscopic 3D display technique and a prototype utilizing a dual projector light engine. The solution described is able to form dynamic exit pupils under the control of a multi-user head-tracker. A prototype completed recently is able to provide a glasses-free solution for a single user at a fixed position. At the end of the prototyping phase it is expected to enable a multiple user interface with an integration of the pupil tracker and the spatial light modulator.Publication Metadata only Beyond social mobility: Biographies, habitus and responses to changing 'Conditions of Existence' among university scholarship students(Sage, 2021) N/A; N/A; Nimer, Maissam; Researcher; Migration Research Program at Koç University (MIReKoç) / Göç Araştırmaları Uygulama ve Araştırma Merkezi (MIReKoç); N/A; N/A; 355744Wider access to higher education at a global level has been accompanied by growing literature on experiences of social mobility often using the concept of habitus as a theoretical tool to frame responses to changes in 'conditions of existence'. Drawing on the case study of a scholarship programme within an elite university in Lebanon, through in-depth interviews with students and university faculty and staff, this article elaborates on the typologies in responses that emerged as students position themselves in a new environment. These typologies, in contrast to the literature which presents them as a result of alterations in the habitus, appear to be related to each other and occur simultaneously within one person's trajectory. As such, instead of viewing these responses as degrees of incorporation of each set of schemes of perceptions from both fields, the context of origin and the new social context appear to be multi-faceted, and the interaction between them is complex. I argue, along the lines of Lahire's dispositional perspective, that the situation of contradictory experiences is not exceptional but characterizes all individuals to a certain extent, especially in the Lebanese context which is distinguished by its diversity in terms of regional and religious affiliations and in which class intersects with other types of identifications.Publication Metadata only Direct identification of A-to-I editing sites with nanopore native RNA sequencing(NATURE PORTFOLIO, 2022) Nguyen, Tram Anh; Heng, Jia Wei Joel; Kaewsapsak, Pornchai; Kok, Eng Piew Louis; Stanojevic, Dominik; Liu, Hao; Cardilla, Angelysia; Praditya, Albert; Yi, Zirong; Lin, Mingwan; Aw, Jong Ghut Ashley; Ho, Yin Ying; Peh, Kai Lay Esther; Wang, Yuanming; Zhong, Qixing; Heraud-Farlow, Jacki; Xue, Shifeng; Walkley, Carl; Ho, Ying Swan; Sikic, Mile; Wan, Yue; Tan, Meng How; N/A; Reversade, Bruno; Faculty Member; School of Medicine; 274182Inosine is a prevalent RNA modification in animals and is formed when an adenosine is deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly as variants from Illumina RNA-sequencing data because they are interpreted as guanosines by cellular machineries. However, this indirect method performs poorly in protein-coding regions where exons are typically short, in non-model organisms with sparsely annotated single-nucleotide polymorphisms, or in disease contexts where unknown DNA mutations are pervasive. Here, we show that Oxford Nanopore direct RNA sequencing can be used to identify inosine-containing sites in native transcriptomes with high accuracy. We trained convolutional neural network models to distinguish inosine from adenosine and guanosine, and to estimate the modification rate at each editing site. Furthermore, we demonstrated their utility on the transcriptomes of human, mouse and Xenopus. Our approach expands the toolkit for studying adenosine-to-inosine editing and can be further extended to investigate other RNA modifications.Publication Metadata only Contact mechanics between the human finger and a touchscreen under electroadhesion(Natl Acad Sciences, 2018) Scaraggi, Michele; Persson, Bo N. J.; N/A; N/A; Department of Mechanical Engineering; Ayyıldız, Mehmet; Şirin, Ömer; Başdoğan, Çağatay; Researcher; PhD Student; Faculty Member; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 125489The understanding and control of human skin contact against technological substrates is the key aspect behind the design of several electromechanical devices. Among these, surface haptic displays that modulate the friction between the human finger and touch surface are emerging as user interfaces. One such modulation can be achieved by applying an alternating voltage to the conducting layer of a capacitive touchscreen to control electroadhesion between its surface and the finger pad. However, the nature of the contact interactions between the fingertip and the touchscreen under electroadhesion and the effects of confined material properties, such as layering and inelastic deformation of the stratum corneum, on the friction force are not completely understood yet. Here, we use a mean field theory based on multiscale contact mechanics to investigate the effect of electroadhesion on sliding friction and the dependency of the finger-touchscreen interaction on the applied voltage and other physical parameters. We present experimental results on how the friction between a finger and a touchscreen depends on the electrostatic attraction between them. The proposed model is successfully validated against full-scale (but computationally demanding) contact mechanics simulations and the experimental data. Our study shows that electroadhesion causes an increase in the real contact area at the microscopic level, leading to an increase in the electrovibrating tangential frictional force. We find that it should be possible to further augment the friction force, and thus the human tactile sensing, by using a thinner insulating film on the touchscreen than used in current devices.Publication Metadata only Peripapillary choroidal vasculature in pediatric eyes with type 1 diabetes mellitus(Kare Yayıncılık, 2022) N/A; N/A; Hasanreisoğlu, Murat; Kesim, Cem; Uzunay, Nur Sena; Taş, Ayşe Yıldız; Karslıoğlu, Melisa Zişan; Şahin, Afsun; Faculty Member; Teaching Faculty; Undergraduate Student; Faculty Member; Doctor; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; N/A; N/A; N/A; N/A; Koç University Hospital; N/A; 182001; 387367; N/A; 200905; N/A; 171267Objectives: choroidal vasculature change in children with diabetes mellitus is not investigated enough although it could reflect clinical outcome. Methods: pediatric Type 1 diabetes mellitus (T1DM) patients and healthy controls were retrospectively evaluated. Peripapillary retinal nerve fiber layer optical coherence tomography (OCT) images of the right eyes were analyzed. Choroidal parameters including total choroidal area, luminal area, stromal area, and choroidal vascularity index were measured through image binarization. Results: twenty eyes of 20 patients were compared with 46 eyes of 46 healthy controls. Mean total choroidal area, luminal area, and stromal area were 1.59±0.35, 1.10±0.24, and 0.50±0.13 mm2 in patients’ eyes and 1.52±0.49, 1.05±0.34, and 0.47±0.17 mm2 in healthy eyes. No difference was found in choroidal vascularity indices between patients and healthy eyes (68.8±3.9% vs. 69.4±4.4%, p=0.521). Temporal choroidal vascularity index was significantly higher than its nasal counterpart in healthy eyes (71.8±5.0% vs. 68.6±4.9%, p<0.001) which was not significant in patients’ eyes (70.7±4.0% vs. 68.9±5.1%, p=0.067). Temporal quadrant had the highest choroidal vascularity index score among all quadrants in healthy controls (all p<0.05), whereas no choroidal vascularity index difference between quadrants was detected in patients (p=0.75). Conclusion: peripapillary choroidal vasculature has shown subtle sectoral changes which did not reflect the overall peripapillary OCT section in pediatric T1DM patients when compared with healthy controls.Publication Metadata only How, when, and why do attribute-complementary versus attribute-similar cobrands affect brand evaluations: a concept combination perspective(Oxford Univ Press Inc, 2015) Swaminathan, Vanitha; Kubat, Umut; Department of Business Administration; N/A; Canlı, Zeynep Gürhan; Şanlı, Ceren Hayran; Faculty Member; PhD Student; Department of Business Administration; College of Administrative Sciences and Economics; Graduate School of Business; 16135; 275215Extant research on cobranding does not examine when and why complementarity or similarity between cobranding partners can be more effective. This research examines consumers' reactions to cobranded partnerships that feature brands with either complementary or similar attribute levels, both of which are common in the marketplace. The results of six experiments show that consumers' evaluations vary as a function of concept combination interpretation strategy (property mapping or relational linking) and whether cobranded partners have complementary or similar attributes. Specifically, when consumers use property mapping, they evaluate cobranded partnerships with complementary (vs. similar) attribute levels more favorably. In contrast, when using relational linking, they evaluate cobranded partnerships with complementary (vs. similar) attribute levels less favorably. The results also reveal that the breadth of the host brand (broad vs. narrow) and the type of advertising influence the extent to which consumers are likely to use property mapping or relational linking in evaluating cobranded partnerships.Publication Metadata only Live birth following early follicular phase oocyte collection and vitrified-warmed embryo transfer 8 days later(Elsevier Sci Ltd, 2015) Hatirnaz, Safak; Hatirnaz, Ebru; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910A 30-year-old woman with premature ovarian insufficiency had two follicles measuring 17 mm and 14 mm on day 3 of her menstrual cycle. Serum oestradiol concentration was 210 pg/ml. Recombinant human chorionic gonadotrophin was given and 5 mg/day letrozole started orally. One metaphase II oocyte was collected 36 h later. A 4-cell embryo was vitrified on the second day after fertilization. Letrozole was stopped on cycle day 8 due to absence of any other visible antral follicles. Oestradiol valerate 6 mg/day was started and the endometrium was 9.2 mm on cycle day 11. The embryo was warmed and transferred on cycle day 13, the 8th day after oocyte retrieval. Luteal phase support with progesterone, oestradiol and low molecular weight heparin was started on the day of transfer and continued until the 10th gestational week. A healthy girl weighing 3200 g was born at term. Early follicular phase oocyte collection did not result in early opening of the implantation window. Apparently secretory transformation was not started until luteal phase support, enabling a cleavage stage embryo transferred 8 days later to implant. Either corpus luteum formation could be disrupted or the endometrium could remain unresponsive to progesterone during the early follicular phase.Publication Metadata only Strategies for controlled ovarian stimulation in the setting of ovarian aging(Thieme Medical Publ Inc, 2015) Seli, Emre; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910In the context of assisted reproduction, the term ovarian aging is often used to refer to declining potential of ovaries to produce oocytes in adequate number or quality in response to controlled ovarian stimulation (COS). Different aspects of COS have been modified with the intention to increase the number and quality of oocytes obtained for in vitro fertilization. In the setting of ovarian aging, suppression of the luteinizing hormone (LH) surge with gonadotropin-releasing hormone (GnRH) antagonist or short GnRH agonist protocol and stimulation with a daily gonadotropin dosage of300 IU/day seem to be appropriate first choices, and there is a strong need for well-designed randomized controlled trials investigating effects of addition of LH activity, estradiol priming, transdermal testosterone administration, and growth hormone supplementation. Given the lack of high-quality evidence showing effectiveness of one approach over another, other factors such as duration of stimulation, total gonadotropin consumption and cost of medication, patient friendliness, and possible side effect profiles must be considered in tailoring the COS protocol according to each individual's needs and desires.Publication Metadata only Multiple sclerosis burden of illness study for Turkey(ELSEVIER, 2018) Şentürk, A.; Kocaman, Sağduyu A.; Irkec, C.; Kuşçu, Yandım D.; Yıldırım, Agan K.; Eraksoy, M.; Kurtuncu, M.; Terzi, M.; Türkoğlu, R.; Yanık, L.; Koç, E.; Erdogan-Çiftçi, E.; Becit, G.; Dönmez, S.; Şafak, K.; Gökalp, T.; Erdoğan, A.; N/A; Altıntaş, Ayşe; Faculty Member; N/A; School of Medicine; N/A; 11611