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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Live birth following early follicular phase oocyte collection and vitrified-warmed embryo transfer 8 days later(Elsevier Sci Ltd, 2015) Hatirnaz, Safak; Hatirnaz, Ebru; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910A 30-year-old woman with premature ovarian insufficiency had two follicles measuring 17 mm and 14 mm on day 3 of her menstrual cycle. Serum oestradiol concentration was 210 pg/ml. Recombinant human chorionic gonadotrophin was given and 5 mg/day letrozole started orally. One metaphase II oocyte was collected 36 h later. A 4-cell embryo was vitrified on the second day after fertilization. Letrozole was stopped on cycle day 8 due to absence of any other visible antral follicles. Oestradiol valerate 6 mg/day was started and the endometrium was 9.2 mm on cycle day 11. The embryo was warmed and transferred on cycle day 13, the 8th day after oocyte retrieval. Luteal phase support with progesterone, oestradiol and low molecular weight heparin was started on the day of transfer and continued until the 10th gestational week. A healthy girl weighing 3200 g was born at term. Early follicular phase oocyte collection did not result in early opening of the implantation window. Apparently secretory transformation was not started until luteal phase support, enabling a cleavage stage embryo transferred 8 days later to implant. Either corpus luteum formation could be disrupted or the endometrium could remain unresponsive to progesterone during the early follicular phase.Publication Metadata only Strategies for controlled ovarian stimulation in the setting of ovarian aging(Thieme Medical Publ Inc, 2015) Seli, Emre; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910In the context of assisted reproduction, the term ovarian aging is often used to refer to declining potential of ovaries to produce oocytes in adequate number or quality in response to controlled ovarian stimulation (COS). Different aspects of COS have been modified with the intention to increase the number and quality of oocytes obtained for in vitro fertilization. In the setting of ovarian aging, suppression of the luteinizing hormone (LH) surge with gonadotropin-releasing hormone (GnRH) antagonist or short GnRH agonist protocol and stimulation with a daily gonadotropin dosage of300 IU/day seem to be appropriate first choices, and there is a strong need for well-designed randomized controlled trials investigating effects of addition of LH activity, estradiol priming, transdermal testosterone administration, and growth hormone supplementation. Given the lack of high-quality evidence showing effectiveness of one approach over another, other factors such as duration of stimulation, total gonadotropin consumption and cost of medication, patient friendliness, and possible side effect profiles must be considered in tailoring the COS protocol according to each individual's needs and desires.Publication Metadata only Understanding follicle growth in vitro: are we getting closer to obtaining mature oocytes from in vitro-grown follicles in human?(Wiley, 2017) Güzel, Yılmaz; N/A; Öktem, Özgür; Faculty Member; School of Medicine; 102627Obtaining and fertilizing mature oocytes from immature follicles that were grown outside the body has conceptually attracted scientists for centuries, with initial attempts first documented in the 19th century. Significant progress has been made since then, due in part to a better understanding of folliculogenesis and improved techniques of in vitro follicle growth. Indeed, in vitro growth is now considered a reasonable approach to preserve or restore fertility when immature follicles and their oocytes need to be grown and matured outside the body. Certain patients would benefit from in vitro follicle growth, particularly those who carry a risk of cancer re-seeding after grafting of frozen-thawed ovarian tissue or who are at the risk of premature ovarian failure due to several intrinsic ovarian defects and genetic mutations that lead to accelerated follicle atresia and early exhaustion of the ovarian reserve. This review provides an update on the current status of in vitro growth of preantral human follicles, from initial efforts to the most recent achievements.Publication Metadata only Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer)(Oxford Univ Press, 2018) Abou Setta, A.; Seyhan, A.; Buckett, W.; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 232576N/APublication Metadata only Utilization of the Bologna criteria: a promise unfulfilled? A review of published and unpublished/ongoing trials(Elsevier, 2018) Boza, Ayşen; N/A; Yıldız, Şule; Mısırlıoğlu, Selim; Yakın, Kayhan; Urman, Cumhur Bülent; Faculty Member; Doctor; Faculty Member; Faculty Member; School of Medicine; N/A; School of Medicine; School of Medicine; N/A; Koç University Hospital; N/A; N/A; 134205; N/A; 106822; 12147Objective: To study the use of the Bologna criteria (BC) for the definition of poor ovarian responders (POR) in clinical practice and research. Design: Systematic review of published and unpublished/ongoing trials between January 2012 and August 2017 on POR. Setting: Not applicable. Patient(s): Not applicable. Intervention(s): The databases were searched using the relevant medical subject headings including all subheadings. The search was limited to humans and English language. The references of the included studies were cross-searched for possibly missed articles. Only clinical trials providing an evidence level >= III were included. Case reports, review, letters, and hypothetical articles were excluded. Main Outcome Measure(s): Extracted studies were divided into two groups: studies in which the BC were used or not. Result(s): One hundred nine published clinical studies analyzing a total of 30,540 women and 112 unpublished/ongoing trials were identified. The BC were used to define POR in 56 (51%) of the published and 44 (39%) of the unpublished trials. The use of the BC gradually increased from 29% to 53% from 2012 to 2017. Asian researchers were more likely to use the BC compared with European and North American researchers (65%, 49%, and 23%, respectively). Neither the design of the study nor the impact factor of the publishing journal was correlated with the use of the BC. Conclusion(s): There is still reluctance to use the BC for the definition of POR, which makes it difficult to combine data from small studies and reach a meaningful conclusion. (C) 2017 by American Society for Reproductive Medicine.Publication Metadata only The expressions of ovarian steroidogenic enzymes do not increase proportionally after FSH, creating a shunting that promotes progesterone output in the granulosa cells without luteinization(Oxford University Press (OUP), 2016) Seyhan, A.; Keles, I.; Balaban, B.; N/A; N/A; N/A; N/A; Akın, Nazlı; Bildik, Gamze; Urman, Defne; Urman, Cumhur Bülent; Öktem, Özgür; Master Student; Teaching Faculty; Master Student; N/A; Faculty Member; Faculty Member; Graduate School of Health Sciences; School of Medicine; Graduate School of Health Sciences; N/A; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; 12147; 102627N/APublication Metadata only Outcomes of laparoscopic peritoneal vaginoplasty operation in patients with mullerian agenesis(Oxford University Press (OUP), 2017) Uncu, G.; Orhan, A.; Aslan, K.; Kasapoglu, I.; Atalay, M. A.; Ozerkan, K.; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910N/APublication Metadata only Effect of hemostatic method on ovarian reserve following laparoscopic endometrioma excision; comparison of suture, hemostatic sealant, and bipolar dessication. a systematic review and meta-analysis(Oxford Univ Press, 2015) Ata, A. Seyhan; N/A; Ata, Mustafa Barış; Türkgeldi, Engin; Urman, Cumhur Bülent; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; Koç University Hospital; 182910; 329649; 12147Publication Metadata only Molecular evidence against the preventive actions of GnRH agonists in chemotherapy induced damage in human ovary and granulosa cells(2015) Güzel, Y.; Urman, B; N/A; Bildik, Gamze; Akın, Nazlı; Taşkıran, Çağatay; Selek, Uğur; Öktem, Özgür; Teaching Faculty; Master Student; Faculty Member; Faculty Member; Faculty Member; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; 134190; 27211; 102627N/APublication Metadata only Global gene expression analysis of blastocyst implantation on 2D and 3D implantation models: towards a comprehensive and inclusive research(Oxford Univ Press, 2018) Sari, K.; Yucel, D.; N/A; Karahüseyinoğlu, Serçin; Faculty Member; School of Medicine; School of Medicine; 110772N/A