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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Determination of the plasma levels of growth arrest specific 6 in colon cancer patients(Marmara Univ, Inst Health Sciences, 2023) Tezcan, Songul; Izzettin, Fikret Vehbi; Ozakpinar, Ozlem Bingol; Atalay, Vafi; Uras, Fikriye; Yumuk, Perran Fulden; School of MedicineObjective: Growth arrest-specific 6 (GAS 6) has a role in cell proliferation and was detected in different cancer types. The aim of this study was to evaluate the plasma GAS 6 levels in colon cancer patients. Methods: This was a prospective study and conducted in a research and training hospital in Turkey. Thirty-three healthy volunteers were enrolled in the control group, thirty-three colon cancer patients who were diagnosed with colon cancer for the first time. Sociodemographic characteristics of participants were recorded. Blood samples of the control group were taken once a time. Patients' blood samples were taken before and one month after surgery. Results: There were no statistically significant differences between the sociodemographic characteristics of the two groups. The mean plasma GAS 6 levels in control were significantly higher than that of colon cancer patients (p<.0001). There is a statistically significant increase in GAS 6 values after surgery (p<.0001). Conclusion: It was observed that plasma GAS 6 levels of the patients were lower than the control group and were elevated after surgery. We think that our study will contribute to the literature in addition to studies showing that GAS 6 levels may be associated with survival and prognosis in different cancer types.Publication Metadata only In reference to difficult tracheal intubation and airway outcomes after radiation for nasopharyngeal carcinoma(Wiley, 2023) Somay, Efsun; Topkan, Erkan; Selek, Uğur; School of MedicineN/APublication Metadata only Author correction: combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma(Nature Research, 2024) Mazur PK, Herner A, Mello SS, Wirth M, Hausmann S, Sánchez-Rivera FJ, Lofgren SM, Kuschma T, Hahn SA, Vangala D, Trajkovic-Arsic M, Gupta A, Heid I, Noël PB, Braren R, Kleeff J, Sipos B, Sayles LC, Heikenwalder M, Heßmann E, Ellenrieder V, Esposito I, Jacks T, Bradner JE, Khatri P, Sweet-Cordero EA, Attardi LD, Schmid RM, Schneider G, Sage J, Siveke JT.; Koç University HospitalIn the originally published version of this article, there were errors in the histological sections depicted in Supplementary Figs. 4 and 10. Specifically: In Supplementary Fig. 4, the image of the Ki67 immunohistochemistry (IHC) for the Gemcitabine+JQ1 group was incorrect In Supplementary Fig. 10, the pSTAT3 image for the IHC for the JQ1 group was incorrect In Supplementary Fig. 10, Ki67 and MYC IHC images for JQ1 and JQ1+SAHA were swapped In Supplementary Fig. 4, the image of the Ki67 immunohistochemistry (IHC) for the Gemcitabine+JQ1 group was incorrect In Supplementary Fig. 10, the pSTAT3 image for the IHC for the JQ1 group was incorrect In Supplementary Fig. 10, Ki67 and MYC IHC images for JQ1 and JQ1+SAHA were swapped The original data were available and these errors have been corrected in the Supplementary Information accompanying this notice. Additionally, the authors wish to clarify that the Sirius Red staining for the control and JQ1 groups were identical in both Supplementary Figs. 4 and 10 because the control mice (JQ1 only or control treatment) were shared between experiments. To avoid confusion, the sections depicting Sirius Red staining for the control and JQ1 groups in Supplementary Fig. 4 were replaced with alternative sections from the same respective samplesPublication Metadata only Understanding patterns of accumulation: improving forecast-based decisions via nudging(Springer, 2024) Boz-Yilmaz, Hatice Zulal; Department of Psychology; Gököz, Zeynep Ayşecan Boduroğlu; Department of Psychology; College of Social Sciences and HumanitiesIn this study we investigated challenges associated with comprehension of graphical patterns of accumulation (Experiment 1) and how to improve accumulation-based reasoning via nudging (Experiment 2). On each trial participants were presented with two separate graphs, each depicting a linear, saturating, or exponential data trajectory. They were then asked to make a binary decision based on their forecasts of how these trends would evolve. Correct responses were associated with a focus on the rate of increase in graphs; incorrect responses were driven by prior knowledge and beliefs regarding the context and/or selective attention towards the early phases of the line trajectories. To encourage participants to think more critically and accurately about the presented data, in Experiment 2, participants completed a nudge phase: they either made a forecast about a near horizon or read particular values on the studied trajectories prior to making their decisions. Forecasting about how the studied trajectories would progress led to improvements in determining expected accumulation growth. Merely reading values on the existing trajectory did not lead to improvements in decision accuracy. We demonstrate that actively asking participants to make specific forecasts prior to making decisions based on the accumulation trajectories improves decision accuracy.Publication Metadata only Dynapenic abdominal obesity and metabolic health in non-geriatric patients with obesity(Mary Ann Liebert Inc., 2023) Akbas, Feray; Atmaca, Hanife Usta; Dereli, Dilek Yazıcı; School of MedicineBackground: Dynapenic abdominal obesity (DAO) is the combination of low muscle strength and high central adiposity, which can lead to functional and cardiometabolic impairments. Objective: The aim of this study was to examine the relationship between DAO and metabolic parameters in non-geriatric patients with obesity. Methods: All patients seen in the obesity outpatient clinic during a random month, along with 30 healthy individuals, were included in the study. Body mass index (BMI), waist circumference (WC), hip circumference (HC), serum fasting blood glucose, triglyceride, high-density lipoprotein, low-density lipoprotein (LDL), insulin, and glycated hemoglobin (HbA1c) levels were measured. Muscle function tests were conducted. Hypertension and diabetes mellitus diagnoses were recorded. DAO was determined using handgrip strength and WC. Metabolic syndrome was defined based on International Diabetes Federation (IDF) criteria. Data were analyzed using SPSS. Results: A total of 106 individuals participated in the study, including 76 individuals with obesity as the case group and 30 healthy individuals as the control group. In the case group, BMI, WC, HC, and chair stand test results were higher compared to the control group. There was no significant difference between the case and control groups in terms of gait speed or handgrip test results. In the case group, 30 people (39.5%) had dynapenic obesity (DO), and in the control group, 8 people (26.7%) had DO. There was no significant difference in DO rates between the case and control groups. In the case group, the HbA1c level was higher in DO (+) group than DO (-) group. In the control group, DO (+) group had higher LDL and HbA1c level than DO (-) group. No significant difference was observed in other search parameters between the DO (+) and DO (-) groups in both the case and control groups. Conclusion: DAO is common among people with obesity and contributes to a poor prognosis, increased morbidity, and mortality. Therefore, including its treatment in the management of obesity is crucial for individuals of all age ranges.Publication Metadata only The role of culture and semantic organization in working memory updating(Routledge Journals, Taylor and Francis Ltd, 2024) Leger, Krystal R.; Snyder, Hannah R.; Gutchess, Angela; Department of Psychology; Gököz, Zeynep Ayşecan Boduroğlu; Department of Psychology; College of Social Sciences and HumanitiesWesterners tend to relate items in a categorical manner, whereas Easterners focus more on functional relationships. The present study extended research on semantic organization in long-term memory to working memory. First, Americans' and Turks' preferences for categorical versus functional relationships were tested. Second, working memory interference was assessed using a 2-back working memory paradigm in which lure items were categorically and functionally related to targets. Next, a mediation model tested direct effects of culture and semantic organization on working memory task behaviour, and the indirect effect, whether semantic organization mediated the relationship between culture and working memory interference. Whereas Americans had slower response times to correctly rejecting functional lures compared to categorical lures, conditions did not differ for Turks. However, semantic organization did not mediate cultural difference in working memory interference. Across cultures, there was evidence that semantic organization affected working memory errors, with individuals who endorsed categorical more than functional pairings committing more categorical than functional errors on the 2-back task. Results align with prior research suggesting individual differences in use of different types of semantic relationships, and further that literature by indicating effects on interference in working memory. However, these individual differences may not be culture-dependent.Publication Metadata only The flashbulb-like nature of memory for the first Covid-19 case and the impact of the emergency. A cross-national survey(Routledge Journals, Taylor and Francis Ltd, 2024) Lanciano, Tiziana; Alfeo, Federica; Curci, Antonietta; Marin, Claudia; D'Uggento, Angela Maria; Decarolis, Diletta; Oner, Sezin; Anthony, Kristine; Barzykowski, Krystian; Bascon, Miguel; Benavides, Alec; Cabildo, Anne; de la Mata-Benitez, Manuel Luis; Filip, Katarzyna; Gofman, Alena; Janssen, Steve M. J.; Kai-bin, Zhao; Markostamou, Ioanna; Matias-Garcia, Jose Antonio; Nourkova, Veronika; Oleksiak, Sebastian; Santamaria, Andres; Szpunar, Karl; Taylor, Andrea; Watson, Lynn Ann; Zheng, Jin; Department of Psychology; Ergen, İrem; Department of Psychology; College of Social Sciences and HumanitiesFlashbulb memories (FBMs) refer to vivid and long-lasting autobiographical memories for the circumstances in which people learned of a shocking and consequential public event. A cross-national study across eleven countries aimed to investigate FBM formation following the first Covid-19 case news in each country and test the effect of pandemic-related variables on FBM. Participants had detailed memories of the date and others present when they heard the news, and had partially detailed memories of the place, activity, and news source. China had the highest FBM specificity. All countries considered the Covid-19 emergency as highly significant at both the individual and global level. The Classification and Regression Tree Analysis revealed that FBM specificity might be influenced by participants' age, subjective severity (assessment of Covid-19 impact in each country and relative to others), residing in an area with stringent Covid-19 protection measures, and expecting the pandemic effects. Hierarchical regression models demonstrated that age and subjective severity negatively predicted FBM specificity, whereas sex, pandemic impact expectedness, and rehearsal showed positive associations in the total sample. Subjective severity negatively affected FBM specificity in Turkey, whereas pandemic impact expectedness positively influenced FBM specificity in China and negatively in Denmark.Publication Metadata only Autobiographical phenomenology of memories of fiction(Routledge Journals, Taylor and Francis Ltd, 2024) Department of Psychology; Çetin, Osman Görkem; Gülgöz, Sami; Department of Psychology; Graduate School of Social Sciences and Humanities; College of Social Sciences and HumanitiesMost autobiographical memories are based on real-life experiences, but memories of fiction have many similarities to real-life autobiographical memories. However, the phenomenological nature of this similarity, the potential differences between media types, and the role of individual differences need further investigation. Based on previous findings, we expected differences between media types on emotional intensity, sensory vividness, and confidence about the recall. To provide insight into these issues, we collected one real-life autobiographical memory and one memory of fiction (book, film, or video game) from 291 participants. We asked them to rate their memories phenomenologically. The participants also provided information regarding their motivations for engaging with fictional stories. Our results show phenomenological differences in several dimensions between media types and differences in the similarity of media types to real-life memories. While absorption seems to be a good predictor for immersion, escapism tendency is a motivation to engage with fiction frequently.Publication Metadata only Evaluation of the interrater reliability of sonographic measurements of muscle thickness of 38 piriformis muscles in 19 patients with piriformis syndrome(International Scientific Information, Inc., 2024) Caglar, Sibel; Taşkıran, Özden Özyemişçi; School of MedicineBackground: The piriformis muscle is a flat superficial muscle of the deep gluteal muscles that externally rotates the hip. Ultrasound is widely used to identify the piriformis muscle, especially for guidance of the needle during injections; however, its diagnostic use has recently gained popularity. The operator-dependent nature of ultrasound requires demonstration of reliability between operators. This study aimed to evaluate interrater reliability of sonographic measurements of muscle thickness of 38 piriformis muscles in 19 patients with piriformis syndrome. Material/Methods: An ultrasound transducer was placed transversely on the sacral spinous process and moved caudo-laterally until the piriformis muscle was visualized under the gluteus maximus while patients were lying in prone position. The thickness of piriformis muscle was measured with a 2 to 5-MHz broadband curvilinear transducer in 3 regions (thickest regions of muscle over the ilium, near the greater trochanter, and near the sacrum). The interrater reliability of measurements of 2 examiners who were blinded to each other’s measurements was assessed by intraclass correlation coefficient. Results: In total, 114 samples from 38 piriformis muscles of 19 patients with a diagnosis of piriformis syndrome were evaluated by 2 raters in this study. The median (interquartile range) patient age was 41 (15) years. Intraclass correlation coefficient value for overall thickness measurements of piriformis muscle was 0.836. Intraclass correlation coefficient values for 3 different regions were over the ilium, near the greater trochanter, and near the sacrum were 0.777, 0.883, and 0.811, respectively. Conclusions: Ultrasound measurement of piriformis muscle thickness has good interrater reliability.Publication Metadata only Details in hand: how does gesturing relate to autobiographical memory?(Routledge, 2024) Güneş Acar, Naziye; Tekcan, Ali İ.; Department of Psychology; Göksun, Tilbe; Department of Psychology; College of Social Sciences and HumanitiesGestures are an integral and inseparable component of speech and people frequently use gestures when retelling their autobiographical memories. This study investigates whether gestures are associated with the retrieval of episodically and phenomenologically rich memories and how this association changes during development. Thirty-five children and 46 adults were asked to report autobiographical memories. Then, they rated the recalled memories on phenomenological qualities. Episodic and non-episodic details of autobiographical memories and representational gestures produced during memory narration were coded. The use of representational gestures was positively correlated with the episodic details of adult memories; however, the same correlation was not present in child memories. The representational gesture use was not associated with the phenomenological qualities in both groups. Gesture use may be related to the retrieval of autobiographical memories, particularly in adults capable of reporting long, coherent memories.