Publications without Fulltext
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
Browse
182 results
Filters
Advanced Search
Filter by
Settings
Search Results
Publication Metadata only Evidence of mitophagy in lens capsule epithelial cells of patients with pseudoexfoliation syndrome(Lippincott Williams and Wilkins, 2024) N/A; Aydemir, Dilara; Sönmez, Sadi Can; Kısakürek, Zeynep Büşra; Gözel, Merve; Karslıoğlu, Melisa Zişan; Güleser, Ümit Yaşar; Şahin, Afsun; Hasanreisoğlu, Murat; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of Medicine; Koç University HospitalPurpose Pseudoexfoliation Syndrome (PEX) is a condition in which aberrant fibrillary protein builds up in various components of the eye and other extraocular tissues. In this study, we aim to investigate the functionality of intracellular auto-degradative machinery -especially mitophagy- and related genes and proteins in PEX. Methods Anterior lens capsules were obtained from cataracts patients with and without PEX to constitute the PEX group and age-matched controls during microincision cataracts surgery. PINK1-mediated mitophagy markers were evaluated on the transcriptional and translational level via RT-qPCR and immunohistochemistry analysis, respectively. Results The lens epithelial cells of PEX patients were characterized by significantly higher PINK1 gene expression compared to that of the controls (p<0.05). In terms of intensity of staining of expressed proteins, PINK1 (p<0.05), Parkin (p<0.01) and LC3B (p<0.01) were all statistically higher in PEX, compared to the controls. Conclusion Altered auto-degradative response -specifically mitophagy- is a component of increased oxidative stress in PEX patients. The role of this mechanism in emerging complications warrants further research.Publication Metadata only How to detect an inadvertent pregnancy during random start stimulations(Elsevier Inc., 2024) Lawrenz, B; Fatemi, H.M.; Ata, Mustafa Barış; School of MedicineN/APublication Metadata only A case of left testicular artery with high origin passing through a left renal vein fenestration(Via Medica Medical Publishers, 2024) Yılmaz, Ebru; Tatar, Cem; Keskin, Aleyna; Yalçın, Büşra; Gürses, İlke Ali; Graduate School of Health Sciences; School of MedicineBackground: Fenestrations of are extremely rare in the venous system, especially renal veins. This paper aims to present a case of left renal vein fenestration where a high origin testicular artery passes through it. Materials and Methods The variation was observed incidentally in a 74-year-old Caucasian male cadaver during routine retroperitoneal dissections for second year medical students. Results: A fenestration in the mid portion of the left renal vein was observed. The length and height of the fenestration was 23 and 3.6 millimeters, respectively. The left testicular artery passed through the fenestration and followed a normal course distal to the fenestration. Posterior to the left renal vein, the testicular artery originated from the lateral aspect of abdominal aorta, just caudal to the left renal artery. On the right side, the testicular artery had a similar high origin, and two renal arteries were present. No venous variations were observed on the right side. Conclusions: The long course of the left renal vein is a factor of preference for donor kidney selection. Uncommon variations of the left renal veins, such as fenestrations, might result in a change in surgical technique and would put the left donor kidney at risk of prolonged anastomosis time and lower survival rates.Publication Metadata only European association of nuclear medicine focus 5: consensus on molecular imaging and theranostics in prostate cancer(Elsevier B.V., 2024) Oprea-Lager, DE; MacLennan, S; Bjartell, A; Briganti, A; Burger, IA; de Jong, I; De Santis, M; Eberlein, U; Emmett, L; Fizazi, K; Gillessen, S; Herrmann, K; Heskamp, S; Iagaru, A; Jereczek-Fossa, BA; Kunikowska, J; Lam, M; Nanni, C; O'Sullivan, JM; Panebianco, V; Sala, E; Sathekge, M; Sosnowski, R; Tombal, B; Treglia, G; Tunariu, N; Walz, J; Yakar, D; Dierckx, R; Sartor, O; Fanti, S.; Tilki, Derya; School of Medicine; Koç University HospitalBackground: In prostate cancer (PCa), questions remain on indications for prostate-specific membrane antigen (PSMA) positron emission tomography (PET) imaging and PSMA radioligand therapy, integration of advanced imaging in nomogram-based decision-making, dosimetry, and development of new theranostic applications. Objective: We aimed to critically review developments in molecular hybrid imaging and systemic radioligand therapy, to reach a multidisciplinary consensus on the current state of the art in PCa. Design, setting, and participants: The results of a systematic literature search informed a two-round Delphi process with a panel of 28 PCa experts in medical or radiation oncology, urology, radiology, medical physics, and nuclear medicine. The results were discussed and ratified in a consensus meeting. Outcome measurements and statistical analysis: Forty-eight statements were scored on a Likert agreement scale and six as ranking options. Agreement statements were analysed using the RAND appropriateness method. Ranking statements were analysed using weighted summed scores. Results and limitations: After two Delphi rounds, there was consensus on 42/48 (87.5%) of the statements. The expert panel recommends PSMA PET to be used for staging the majority of patients with unfavourable intermediate and high risk, and for restaging of suspected recurrent PCa. There was consensus that oligometastatic disease should be defined as up to five metastases, even using advanced imaging modalities. The group agreed that [177Lu]Lu-PSMA should not be administered only after progression to cabazitaxel and that [223Ra]RaCl2 remains a valid therapeutic option in bone-only metastatic castration-resistant PCa. Uncertainty remains on various topics, including the need for concordant findings on both [18F]FDG and PSMA PET prior to [177Lu]Lu-PSMA therapy. Conclusions: There was a high proportion of agreement among a panel of experts on the use of molecular imaging and theranostics in PCa. Although consensus statements cannot replace high-certainty evidence, these can aid in the interpretation and dissemination of best practice from centres of excellence to the wider clinical community. Patient summary: There are situations when dealing with prostate cancer (PCa) where both the doctors who diagnose and track the disease development and response to treatment, and those who give treatments are unsure about what the best course of action is. Examples include what methods they should use to obtain images of the cancer and what to do when the cancer has returned or spread. We reviewed published research studies and provided a summary to a panel of experts in imaging and treating PCa. We also used the research summary to develop a questionnaire whereby we asked the experts to state whether or not they agreed with a list of statements. We used these results to provide guidance to other health care professionals on how best to image men with PCa and what treatments to give, when, and in what order, based on the information the images provide.Publication Metadata only Preoperative radiosurgical management of brain metastases: evidence and challenges(Exon Publication, 2023) Topkan, E.; Kucuk, A.; Pehlivan, B.; Şenyürek, Şükran; Sezen, Duygu; Durankuş, Nilüfer Kılıç; Akdemir, Eyüb Yaşar; Bölükbaşı, Yasemin; Selek, Uğur; School of Medicine; Koç University HospitalAbout 30% of all adult patients with solid tumors will develop brain metastases. The prognosis of patients with brain metastasis is poor, with a median overall survival of 4–7 months. Nevertheless, with efficient systemic and local therapies, some specific patient groups may experience longer survival times. Currently, the options for the management of brain metastasis include surgery, systemic chemotherapy, targeted therapies, stereotactic radiosurgery (SRS), postoperative stereotactic radiosurgery, whole-brain radiotherapy (WBRT), and their combination variants. Given the severe neurotoxic effects of WBRT, increased risk of radionecrosis, leptomeningeal dissemination after postoperative SRS, and the ineligibility of certain patients for SRS during the postoperative period (usually first 21 days), an active search for alternative treatment strategies for such patients ensued. It has been suggested that novel preoperative stereotactic radiosurgery, which has a lower risk of radionecrosis and leptomeningeal dissemination, would provide at least equivalent local control rates in this regard. The purpose of the current chapter is to outline the justification and available evidence for the novel preoperative stereotactic radiosurgery in the management of brain metastasis while accepting the paucity of related literature.Publication Metadata only Comment on: predictive value of health-related quality of life on radiotherapy-related toxicities in patients with head and neck cancer(Springer Science and Business Media Deutschland Gmbh, 2023) Somay, Efsun; Topkan, Erkan; Selek, Uğur; School of MedicineN/APublication Metadata only Comments on: carcinoma buccal mucosa treated with definitive hypofractionated accelerated radiotherapy: a retrospective analysis of treatment outcomes(Ovid Technologies, 2023) Somay, E.; Yilmaz, B.; Topkan, E.; Selek, Uğur; School of MedicineN/APublication Metadata only Definitions of radiation-induced trismus in head and neck cancer: current concepts and controversies(NCBI Bookshelf, 2023) Somay, E.; Yilmaz, B.; Topkan, E.; Kucuk, A.; Pehlivan, B.; Selek, Uğur; School of MedicineRadiation-induced trismus is a devastating side effect of radiotherapy in patients with head and neck cancers. It hampers daily activities like eating, speaking, chewing, swallowing, and oral hygiene routines. Radiation-induced trismus also negatively affects social interactions, psychological wellbeing, and lowers the quality of life of patients. The most common method for determining radiation-induced trismus is to measure the ‘maximum mouth opening’. Different cut-off values for maximum mouth opening have been employed in studies that assessed radiation-induced trismus, including 40 mm, 35 mm, 30 mm, and 20 mm. The impact and prevalence of radiation-induced trismus are not fully understood because there is no common and reliable objective measure to determine cut-off values of maximum mouth opening. Additionally, regardless of the pretreatment measures, a standard cut-off is applied to all patients, where a change may be substantial for one patient but not necessarily for another. These discrepancies may cause certain patients’ conditions to be overstated or understated, misdirecting their prophylactic or therapeutic interventions. This chapter highlights the current concepts and controversies of the definitions of radiation-induced trismus, and the possible challenges in managing radiation-induced trismus because of the varied definitions.Publication Metadata only Comment on "a systematic review and meta-analysis of osteoradionecrosis following proton therapy in patients with head and neck cancer"(Elsevier Ltd, 2023) Topkan, E.; Somay, E.; Selek, Uğur; School of MedicineN/APublication Metadata only Challenges in the radiological diagnosis of osteoradionecrosis of the jaw in head and neck cancer patients(Exon Publishing, 2023) Yilmaz, B.; Somay, E.; Kucuk, A.; Pehlivan, B.; Topkan, E.; Selek, Uğur; School of MedicineOne of the most common and severe side effects of radiotherapy or concurrent chemo-radiotherapy for head and neck cancers is osteoradionecrosis of the jaws, which affects 2–22% patients. Correct diagnosis is crucial for the effective and timely management of osteoradionecrosis of the jaws. However, various stages of osteoradionecrosis of the jaws resemble osteomyelitis, medication-related osteonecrosis of the jaw, or tumor recurrences, challenging the diagnostic certainty. The clinical and radiological resemblance of osteoradionecrosis of the jaws to these non-radiotherapy-related conditions are the main contributors to this challenging situation. Nevertheless, it may be possible to avoid diagnostic roadblocks by using image analysis methods such as orthopantomography, computed tomography (CT), magnetic resonance imaging, bone scintigraphy, positron emission tomography, and single-photon emission CT (SPECT). There is no widely accepted consensus on the precise diagnosis of osteoradionecrosis of the jaws, although its general characteristics have been reported in the literature. The current chapter covers osteoradionecrosis of the jaws and its clinical and radiological features and provides information on relevant strategies to be used for an accurate diagnosis, with a specific emphasis on radiological and nuclear medicine techniques.