Publications without Fulltext
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
Browse
392 results
Filters
Advanced Search
Filter by
Settings
Search Results
Publication Metadata only Therapeutic targets of probiotics in Parkinson disease: a systematic review of randomized controlled trials(Iran University of Medical Sciences, 2024) Atak, Elif Sina; Yildiz, Dilara; Kocaturk, Ruemeysa Rabia; Ozcan, Oznur Ozge; Erguzel, Turker Tekin; Karahan, Mesut; Tarhan, Nevzat; Temizyürek, Arzu; School of MedicineIntroduction: Parkinson disease is the world's second most prevalent neurological disease. In this disease, intracytoplasmic neuronal inclusions are observed in enteric neurons in the gastrointestinal tract, and the composition of the intestinal microbiome is altered. These changes correlate with the motor phenotype. A systematic review was conducted to determine the effect of using probiotics in Parkinson disease. Methods: Scopus, PubMed, Web of Science, the Cochrane Library, ScienceDirect, and Ov & imath;dLWW were searched until April 2021. A total of 27395 records were found according to inclusion and exclusion criteria with the following outcomes: Parkinson disease rating, oxidative stress, and gastrointestinal system markers. Data search, article selection, and data extraction assessments were performed according to the PRISMA (preferred reporting items for systematic reviews and meta -analyses) guidelines. The Jadad scale was used to rate the evidence's quality. Results: Our study information was gathered from 5 randomized controlled trials involving 350 individuals with Parkinson disease receiving probiotic supplements. Parkinson disease rating and non -motor symptoms test were performed in the samples. Also, oxidative stress (glutathione, malondialdehyde) and gastrointestinal system symptoms (bowel opening frequency, gut transit time, complete bowel movement, spontaneous bowel movements) were evaluated during 4-12 weeks of using probiotics in these patients. Conclusion: While all high -quality studies demonstrate improvement in disease symptoms of the patients, currently sufficient data are not available to recommend the use of probiotics for people with Parkinson disease in clinical practice.Publication Metadata only HIV and intersectional stigma among people living with HIV and healthcare workers and antiretroviral therapy adherence in the Dominican Republic(SAGE, 2024) Kerr, Jelani; Yigit, Ibrahim; Long, Dustin M.; Paulino-Ramirez, Robert; Waters, John; Hao, Jiaying; Nyblade, Laura; Varas-Diaz, Nelson; Naar, Sylvie; Bond, Christyenne L.; Budhwani, Henna; Turan, Janet Molzan; School of MedicineBackground HIV-related stigma, discrimination, and social marginalization undermines optimal HIV care outcomes. More research examining the impact of HIV-related stigma, discrimination, other interlocking forms of oppression, and antiretroviral therapy (ART) adherence is needed to optimize HIV treatment programming. This study uses data from two clinics in the Dominican Republic to examine client and healthcare worker (HCW) perceptions of HIV and intersectional stigmas among people living with HIV.Methods Surveys exploring demographics, HIV-related stigma, various dimensions of discrimination (race/ethnicity, HIV status, sexual orientation), healthcare engagement, and medication adherence were collected from 148 clients and 131 HCWs. Analysis of variance was conducted to examine differences in stigma by clinic and logistic regressions were used to determine predictors of optimal client medication adherence.Results Perceived discrimination in healthcare facilities due to clients' sexual orientation retained significance in crude and multivariable logistic regression models and was negatively associated with ART adherence (aOR:0.79; 95% CI:0.66, 0.95).Discussion Findings highlight the importance of implementing strategies to address stigma, discrimination, and social marginalization, particularly within healthcare facilities.Publication Metadata only TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease(Kare Publ, 2023) Yilmaz, Yusuf; Adali, Gupse; Cosar, Arif Mansur; Sertesen, Elif; Gokcan, Hale; Bahcecioglu, Halil Ibrahim; Sahin, Mustafa; Tulunay, Cansin; Ergun, Ihsan; Turan, Ilker; Idilman, Ilkay Sedakat; Celikel, Cigdem; Kirimlioglu, Hale; Akyol, Gulen; Yilmaz, Funda; Sokmensuer, Cenk; Guveli, Hakan; Akarca, Ulus Salih; Akyuz, Umit; Genc, Volkan; Akyildiz, Murat; Yazihan, Nuray; Tutar, Engin; Ates, Fehmi; Dincer, Dinc; Balaban, Yasemin; Kiyici, Murat; Akdogan, Meral; Sonsuz, Abdullah; Idilman, Ramazan; Zeybel, Müjdat; School of MedicineNonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primarily intended for gastroenterology, endocrinology, metabolism diseases, cardiology, internal medicine, pediatric specialists, and family medicine specialists.Publication Metadata only Incidence and prognosis of Covid-19 in patients with psoriasis: a multicenter prospective study from the Eastern Black Sea Region of Turkey(Croation Dermatovenerological Soc, 2022) Selcuk, Leyla Baykal; Aksan, Burak; Kulakli, Sevgi; Oguz, Isil Deniz; Gundogdu, Mustafa; Dere, Gokturk; Onder, Sevda; Etgu, Fatma; Arica, Deniz Aksu; Oguzer, Seyda Ece; Aydemir, Burcu; Arica, Ibrahim Etem; Saral, Yunus; Yaylı, Savaş; School of MedicineCovid-19 infection can have a poor prognosis, especial-ly in patients with chronic diseases and those receiving immunosup-pressive or immunomodulating therapies.This study aimed to investigate the severity of Covid-19 infection in patients with psoriasis and compare the infection severity for sys-temic treatments and comorbidities.We conducted a study in the dermatology clinics of five different centers in the Eastern Black Sea region of Turkey. Four hundred and eighty-eight patients were included, and 22.5% were confirmed as having Covid-19 infection.In our study, the frequency of hospitalization rates due to Covid-19 infection were similar (15.4%, 25.9% respectively) in patients receiv-ing biological treatment and receiving non-biological systemic treat-ment (P=0.344). Hospitalization rates were higher in patients with hypertension, androgenetic alopecia, and acitretin use (P=0.043, P=0.028, P=0.040).In conclusion, current biologic treatments and non-biologic system-ic treatments in patients with psoriasis did not appear to increase the risk of the severe form of Covid-19, except for acitretin.Publication Metadata only Persistent genital arousal disorder as an atypical presenting symptom of central nervous system demyelinating disorder(Wolters Kluwer Medknow Publications, 2023) Üçem, Selen; Buluş, Eser; Erkol, Gökhan; School of Medicine; Koç University HospitalN/APublication Metadata only Comment on: intensity modulated radiotherapy in head and neck cancer: initial experience of the first treated cases from North-East India(Springer India, 2023) Topkan, Erkan; Somay, Efsun; Selek, Uğur; School of MedicineN/APublication Metadata only Radiation therapy treatment outcomes for patients with head and neck cancer: a tertiary care centre experience in a tier three town(Springer India, 2023) Yilmaz, B.; Selek, Uğur; School of MedicineN/APublication Metadata only Should we review our prophylaxis approach for increased antibiotic resistance in transrectal prostate biopsy?(The Journal of Infection in Developing Countries (JIDC), 2024) Altunsoy, Adalet; Coser, Seref; Kemirtlek, Nizamettin; Balci, Melih; Bodur, Hurrem; Tuncel, Altug; Aykanat, İbrahim Can; Koç University HospitalIntroduction: This study aims to show the bacteriologic picture of acute prostatitis and bacteremia caused by infective agent after transrectal ultrasound-guided prostate biopsy (TRUSBx) and to determine the resistance rates of the infections in patients undergoing transrectal biopsy and to guide prophylaxis approach before biopsy. Methodology: The retrospective data of 935 patients who underwent TRUSBx between January 2010 to January 2019 were reviewed. Prebiopsy urine cultures and antimicrobial susceptibility were obtained. Subsequently, patients admitted to the hospital with any complaint after biopsy were examined for severe infection complications. Results: Of the 430 (61.7%) patients who underwent urine culture before the procedure, 45 (10.5%) had growth; 30 (66.7%) of the growing microorganisms were Escherichia coli . Twenty (44.4%) of all Gram -negative agents in pre-biopsy urine culture were susceptible to quinolone. Post TRUSBx bacteremia was present in 18.2%, urinary system infection in 83.6%, and hospitalization in 61.8% of 55 patients who were admitted to the hospital. In the isolated gram -negative microorganisms, fluoroquinolones resistance in urinary system infections was seen in 40% and bacteremia was seen in 70% of the cases. ESBL-producing Gram -negative bacteria were determined in 40% of infections in blood and 38.5% of urinary system infections in the post biopsy period in the current study. Conclusions: These high antibiotic resistance rates suggest that we better review our pre-procedure prophylaxis approaches.Publication Metadata only Entrapped surgical needle in the valveless AirSeal trocar: a case report and literature review(Elsevier Science Inc., 2024) N/A; Aykanat, İbrahim Can; Balbay, Mevlana Derya; School of Medicine; Koç University HospitalBackground: Valveless trocars like AirSeal system are maintain a stable pneumoperitoneum and reduce instrument friction. Case presentation: A 65-year-old man's robotic radical cystectomy was complicated by a missing needle while using AirSeal system. The needle was detected via backward inspection using the endo camera inserted through the trocar, tip at its most distal end let the visualization of the needle within the air channels and confirmed with a trocar X-ray. Conclusion: Our findings suggest that retrograde inspection and targeted radiography of the trocar, prior to patient imaging, can be helpful in locating the lost needle and prevent prolongation of surgeries.Publication Metadata only Investigation of childhood pneumonia with thoracic ultrasound: a comparison between X-ray and ultrasound(Lippincott Williams and Wilkins, 2023) Buz Yaşar, Ayşenur; Tarhan, Merve; Atalay, Basak; Girit, Saniye; N/A; School of Medicine; Koç University HospitalChildhood pneumonia is a common entity, and chest x-rays are widely used as an initial diagnostic step. To avoid radiation exposure in the pediatric age group, we assessed whether the diagnostic accuracy of ultrasound (US) imaging is sufficient in the diagnosis. One hundred thirty-three children with pneumonia (72 girls/61 boys) were participated to study between 2019 and 2021. All participants had a chest x-ray. Radiologists who perform the US scans and interpret the x-rays were blinded to each other. A comparative analysis was also done to assess US findings on pneumonia for different age groups. We compare the diagnostic accuracy of US and x-rays by McNemar test and receiver operating characteristic curves. Intraclass correlation coefficient values were calculated for the assessment of interobserver agreement of x-ray evaluation. The participants' ages ranged from 1 month to 17 years and 8 months with a median age of 24 months (Q1: 8 and Q3: 66 months). Hospital stay lengths were longer, consolidation depths were greater, and presence of air bronchogram or pleural effusion was more frequent in school-age children. The proportion of consolidation seen on chest x-ray and transthoracic US scan was significantly different (P < 0.001). The area under the curve was greater in the US than in the chest x-ray (area under the curve, 0.94 and 0.76 respectively). There was a good agreement between the 2 interpreters on chest x-ray assessment (κ = 0.661). The thoracic US can be used as a safe and efficient imaging tool in the diagnosis of pediatric pneumonia. © Wolters Kluwer Health, Inc. All rights reserved.