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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Are the New Kawasaki-like Syndromes in the children associated with Covid-19?(Dokuz Eylül University Institute of Health Sciences, 2024) N/A; Ulusu, Nuriye Nuray; Aydemir, Duygu; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health SciencesCOVID-19 has become a significant public health problem since December 2019, and despite vaccination, people are still infected and have died because of COVID-19. COVID-19 mainly affects older adults and cardiovascular diseases, and immune disorders. On the other hand, some young adults infected by COVID-19 show severe symptoms similar to Kawasaki Disease (KD) called Kawasaki-like syndrome syndromes and cardiovascular complications, including aneurysms, left ventricular dysfunction, pericarditis, myocarditis, valvular regurgitation, or coronary arterial ectasia, tested positive for the COVID19 virus, up to two-thirds of cases. On the other hand, people with glucose-6-phosphate dehydrogenase (G6PD) deficiency are more vulnerable to COVID-19 infection, and KD with G6PD deficiency has been reported previously. Therefore, children with G6PD deficiency or KD disease can be more vulnerable to COVID-19; thus, we discuss the possible role of COVID-19 in KD-like syndrome and G6PD deficiency associated with severe symptoms in children. Also, the possible correlation between COVID-19 infection and Kawasaki disease-like syndromes should be further investigated.Publication Metadata only TASL practice guidance on the clinical assessment and management of patients with nonalcoholic fatty liver disease(Kare Publ, 2023) Yilmaz, Yusuf; Adali, Gupse; Cosar, Arif Mansur; Sertesen, Elif; Gokcan, Hale; Bahcecioglu, Halil Ibrahim; Sahin, Mustafa; Tulunay, Cansin; Ergun, Ihsan; Turan, Ilker; Idilman, Ilkay Sedakat; Celikel, Cigdem; Kirimlioglu, Hale; Akyol, Gulen; Yilmaz, Funda; Sokmensuer, Cenk; Guveli, Hakan; Akarca, Ulus Salih; Akyuz, Umit; Genc, Volkan; Akyildiz, Murat; Yazihan, Nuray; Tutar, Engin; Ates, Fehmi; Dincer, Dinc; Balaban, Yasemin; Kiyici, Murat; Akdogan, Meral; Sonsuz, Abdullah; Idilman, Ramazan; Zeybel, Müjdat; School of MedicineNonalcoholic fatty liver disease (NAFLD) is a multisystem disease and is significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and cardiovascular disease. NAFLD has become the most prevalent chronic liver disease in Western countries, and the proportion of NAFLD-related cirrhosis among patients on liver transplantation waiting lists has increased. In light of the accumulated data about NAFLD, and to provide a common approach with multi-disciplines dealing with the subject, it has become necessary to create new guidance for diagnosing and treating NAFLD. This guidance was prepared following an interdisciplinary study under the leadership of the Turkish Association for the Study of the Liver (TASL), Fatty Liver Special Interest Group. This new TASL Guidance is a practical application guide on NAFLD and was prepared to standardize the clinical approach to diagnosing and treating NAFLD patients. This guidance reflects many advances in the field of NAFLD. The proposals in this guidance are meant to aid decision-making in clinical practice. The guidance is primarily intended for gastroenterology, endocrinology, metabolism diseases, cardiology, internal medicine, pediatric specialists, and family medicine specialists.Publication Metadata only Determination of the plasma levels of growth arrest specific 6 in colon cancer patients(Marmara Univ, Inst Health Sciences, 2023) Tezcan, Songul; Izzettin, Fikret Vehbi; Ozakpinar, Ozlem Bingol; Atalay, Vafi; Uras, Fikriye; Yumuk, Perran Fulden; School of MedicineObjective: Growth arrest-specific 6 (GAS 6) has a role in cell proliferation and was detected in different cancer types. The aim of this study was to evaluate the plasma GAS 6 levels in colon cancer patients. Methods: This was a prospective study and conducted in a research and training hospital in Turkey. Thirty-three healthy volunteers were enrolled in the control group, thirty-three colon cancer patients who were diagnosed with colon cancer for the first time. Sociodemographic characteristics of participants were recorded. Blood samples of the control group were taken once a time. Patients' blood samples were taken before and one month after surgery. Results: There were no statistically significant differences between the sociodemographic characteristics of the two groups. The mean plasma GAS 6 levels in control were significantly higher than that of colon cancer patients (p<.0001). There is a statistically significant increase in GAS 6 values after surgery (p<.0001). Conclusion: It was observed that plasma GAS 6 levels of the patients were lower than the control group and were elevated after surgery. We think that our study will contribute to the literature in addition to studies showing that GAS 6 levels may be associated with survival and prognosis in different cancer types.Publication Metadata only Gait analysis in idiopathic normal pressure hydrocephalus: a single centre experience(Galenos, 2023) Youssef, Hussein; Özkan, Esra; Çakmak, Özgür Öztop; Akar, Kardelen; Kahraman, Atilla Deniz; Samancı, Mustafa Yavuz; Vural, Atay; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of MedicineIntroduction: Gait impairment is the earliest symptom of idiopathic normal pressure hydrocephalus (iNPH). This study objectively investigates gait changes using Ambulatory Parkinson’s Disease Monitoring inertial sensors after cerebrospinal fluid withdrawal in patients with iNPH. Methods: Two-minute walkway tests were performed in eleven patients with iNPH before and after the spinal tap test (TT) or ventriculoperitoneal shunt surgery. Gait parameters were analyzed and compared for each patient individually before and after the intervention. Results: Eleven patients with iNPH (six female, five male) with a median age of 76 (68-76) were included in the study. After the spinal TT or ventriculoperitoneal shunt surgery, patients exhibited increased cadence (steps per minute) and decreased step and stride time (p=0.008, for all). Conclusion: APDM inertial sensors may provide a quantitative gait assessment in patients with iNPH.Publication Metadata only BRAF, NRAS, KIT, TERT, GNAQ/GNA11 mutation profile and histomorphological analysis of anorectal melanomas: a clinicopathologic study(Federation Turkish Pathology Soc, 2023) Sari, Sule Ozturk; Yilmaz, Ismail; Hurdogan, Ozge; Keskin, Metin; Buyukbabani, Nesimi; Gulluoglu, Mine; Taşkın, Orhun Çığ; School of MedicineObjective: Primary anorectal melanomas (AMs) are uncommon neoplasms with aggressive behavior. Molecular profile and clinicopathologic features of AMs are still not well established. In this study, we aimed to investigate BRAF, NRAS, KIT, TERT, and GNAQ/GNA11 mutation status and clinicopathologic features of AMs. Material and Method: All diagnostic slides of 15 AMs were reviewed. Histopathological and follow-up information were documented. Mutations in exon 15 of the BRAF gene; exons 2 and 3 of the NRAS gene; exons 9, 11, 13, 17, and 18 of the KIT gene; and exons 4 and 5 of the GNAQ/GNA11 genes and mutations in the promoter region of the TERT gene (chr.5, 1,295,228C>T and 1,295,250C>T) were analyzed. Results: BRAF(V600E) and KIT(V555I and K642E) mutations were observed in one (7%) and two cases (14%), respectively. NRAS, TERT and GNAQ/GNA11 mutations were not detected. The mean age was 65. Patients presented with rectal mass, rectal bleeding, pain, and weight loss. 73% of the lesions were macroscopically polypoid. The most common tumor cell type was epithelioid. Mean tumor thickness was 10.4 mm. One third of the cases lacked pigmentation. In situ melanoma was present in one third of the cases. Among 14 patients with follow-up data, 12 succumbed to disease. The mean overall survival was 36 months.Conclusion: AMs are uncommon tumors with dismal survival, usually occurring in the elderly in various gross and microscopic appearances. In terms of molecular profile, BRAF and KIT mutations are rarely detected. Profiling of larger cohorts is required to elucidate the pathogenesis and to identify potential molecular indicators that may contribute to the development of individualized targeted therapies.Publication Metadata only Design considerations for clinical trials of radiotherapy combined with immunotherapy(Kare Publ, 2023) Welsh, James; Sezen, Duygu; School of MedicineThe discovery of synergistic effects between radiation and immunotherapy in pre-clinical studies has encouraged researchers to conduct clinical trials testing the effects of combined therapy in patients. The first step in conducting any clinical trial is to define the hypothesis and core objectives. The challenge while developing trials analyzing combinations of immunotherapy and radiation therapy (RT) is to select an appropriate hypothesis that can be tested in the future research, as well as raising new questions for investigation. Here, we review some of the concerns and challenges for designing clinical trials of RT combined with immunotherapy.Publication Metadata only Important considerations for dental safety to prevent osteoradionecrosis of the jaws(Kare Publishing, 2023) Somay, Efsun; Topkan, Erkan; Selek, Uğur; School of MedicinePatients undergoing radiotherapy for malignancies in the head-and-neck region are prone to ex-periencing a range of dental complications. Osteoradionecrosis of the jaw (ORNJ) is a noteworthy complication that occurs infrequently but carries substantial significance, as evidenced by reported occurrence rates ranging from 2% to 22%. ORNJ is distinguished by bone necrosis and the inability to heal properly for at least 3 months. In the majority of cases, ORNJ typically demonstrates a gradual progression characterized by the subsequent development of infections, intra-or extra-oral fistulas, and bone necrosis with or without pathological fractures. There exists a multitude of risk factors that have been postulated to be associated with ORNJ. The literature extensively documents the influence of dental interventions on the progression of ORNJ; however, it continues to be a topic of continuing multidisciplinary debate. Establishing multidisciplinary collaborations that organize data and develop guidelines will be valuable for healthcare professionals operating in this specialized and relatively un -familiar field. Therefore, this review has identified eleven key facts about dental safety precautions to prevent ORNJ and is prepared to give a clear and concise message to reduce the current uncertainty to provide recommendations, explanations, and measures.Publication Metadata only The effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases: objectives and design of a randomized controlled trial(Turkish National Pediatric Society, 2024) Sümengen, Aylin Akça; İsmailoğlu, Abdul Veli; İsmailoğlu, Pelin; Çeliker, Alpay; Namlısesli, Deniz; Poyraz, Ezgi; Subaşı, Damla Özçevik; Erdem, Ceren Zeren; Çakır, Gökçe Naz; N/A; Gümüş, Terman; N/A; Koç University HospitalBackground. Understanding the severity of the disease from the parents’ perspective can lead to better patient outcomes, improving both the child’s health-related quality of life and the family’s quality of life. The implementation of 3-dimensional (3D) modeling technology in care is critical from a translational science perspective. Aim. The purpose of this study is to determine the effect of 3D modeling on family quality of life, surgical success, and patient outcomes in congenital heart diseases. Additionally, we aim to identify challenges and potential solutions related to this innovative technology. Methods. The study is a two-group pretest-posttest randomized controlled trial protocol. The sample size is 15 in the experimental group and 15 in the control group. The experimental group’s heart models will be made from their own computed tomography (CT) images and printed using a 3D printer. The experimental group will receive surgical simulation and preoperative parent education with their 3D heart model. The control group will receive the same parent education using the standard anatomical model. Both groups will complete the Sociodemographic Information Form, the Surgical Simulation Evaluation Form-Part I-II, and the Pediatric Quality of Life Inventory (PedsQL) Family Impacts Module. The primary outcome of the research is the average PedsQL Family Impacts Module score. Secondary outcome measurement includes surgical success and patient outcomes. Separate analyses will be conducted for each outcome and compared between the intervention and control groups. Conclusions. Anomalies that can be clearly understood by parents according to the actual size and dimensions of the child’s heart will affect the preoperative preparation of the surgical procedure and the recovery rate in the postoperative period. © 2024, Turkish National Pediatric Society. All rights reserved.Publication Metadata only Outcome and risk factors for mortality in peritoneal dialysis patients: 22 years of experience in a Turkish center(AVES, 2024) Caliskan, Yasar; Goksoy, Yagmur; Sacli, Fadime Sevgi; Mutlu, Ummu; Turkmen, Aydin; Bozfakioglu, Semra; N/A; Demir, Erol; Koç University Transplant Immunology Research Centre of Excellence (TIREX); Graduate School of Health SciencesBackground: European peritoneal dialysis populations have identified and reported mortality and morbidity risk factors. However, no reports are pointing out the factors affecting the outcomes of these patients during more than 2 decades of follow-up in T & uuml;rkiye. This single -center study aims to evaluate patient mortality and peritonitis rates and estimate confounding factors affecting patient mortality over 22 years. Methods: Adult patients who underwent peritoneal dialysis at our center between December 1994 and December 2016 were enrolled in this retrospective cohort study. The primary outcome of the present study was mortality, and the secondary outcomes were technical failure and peritonitis. Results: Two hundred fifty patients were included in this study. The patients were followed up for a median of 39.5 months (range 17-71). Forty-eight (19.2%) patients died. Survival rates at 5, 10, and 15 years were 86.8% (217/250), 64.6% (86/133), and 41.1% (30/73), respectively. The prevalence of diabetes mellitus [14 (29.2%) vs. 20 (9.9%); P < .001] and cardiovascular disease [16 (33.3%) vs. 24 (11.9%); P < 0.001] were significantly higher in the deceased group compared to the survival group. Cardiovascular disease was the leading cause of death [26 (54.1%)]. Age (hazard ratio (HR) 1.06; 95% CI, 1.04-1.09; P < .001), male sex (HR 2.07; 95% CI, 1.10-3.90; P = .024), and transfer to peritoneal dialysis due to vascular access problems (HR 3.91; 95% CI, 1.90-8.07; P < .001) were associated with mortality in multivariate analysis. Also, catheter exit -site infection, peritonitis rate, catheter removal, and technical complications were similar between the groups. The peritonitis rate was 0.2 episodes per patient per year. Conclusion: The mortality rate of the patient population in our center was similar to Europe and the United States. Cardiovascular diseases and diabetes are the leading causes of death in Turkish peritoneal dialysis patients, as in other populations.Publication Metadata only Radiofrequency ablation of metastatic lymph nodes in a patient requiring secondary operation for papillary thyroid carcinoma metastasis(Turkish Surgical Assoc., 2024) Öner, Gizem; Özçınar, Beyza; Aksakal, Nihat; Salmaslıoğlu, Artur; Yücel, Cem; Erbil, Yeşim; N/A; Ağcaoğlu, Orhan; School of MedicineRadiofrequency ablation is a minimally invasive modality performed as an alternative to surgery in patients with benign thyroid nodules and recurrent thyroid cancers. As far we know there is scant data regarding the safety of radiofrequency ablation for metastatic lymph nodes. In this report, our aim was to evaluate the safety and efficacy of radiofrequency ablation for metastatic lymph nodes in patients with recurrent papillary thyroid cancer metastasis. A 63-year old man, who underwent bilateral total thyroidectomy procedure in a different hospital with the diagnosis of papillary thyroid cancer one year ago, was diagnosed to have papillary thyroid cancer metastasis in single lymph nodes bilaterally in his follow-up. He underwent percutaneous radiofrequency ablation under ultrasound guidance. He was discharged home on post-operative day one uneventfully and his first control ultrasonography revealed a decrease in nodule size larger than 50% in right side of the neck and also the nodule in the left side disappeared. In conclusion, radiofrequency ablation is a safe and feasible technique for the treatment of metastatic lymph nodes in patients requiring secondary surgery due to papillary thyroid cancer metastasis. © Copyright 2024 by Turkish Surgical Society Available online at www.turkjsurg.com./ÖZET Radyofrekans ablasyonu, iyi huylu tiroid nodülü ve tekrarlayan tiroid kanserli hastalarda ameliyata alternatif olarak uygulanan minimal invaziv bir yöntemdir. Metastatik lenf nodları için radyofrekans ablasyon tedavisinin etkinliğine ilişkin az veri bulunmaktadır. Bu yazı, tekrarlayan papiller tiroid kanseri metastazı olan hastalarda metastatik lenf nodları için radyofrekans ablasyonun güvenliğini ve etkinliğini değerlendirmektedir. Bir yıl önce papiller tiroid kanseri tanısıyla farklı bir hastanede bilateral total tiroidektomi işlemi uygulanan 63 yaşında bir erkek hastanın kontrolleri sırasında bilateral lenf nodlarında papiller tiroid kanseri metastazı saptandı. Ultrason eşliğinde perkütan radyofrekans ablasyonu yapıldı. Hasta postoperatif birinci günde sorunsuz bir şekilde taburcu edildi ve ilk kontrol ultrasonografisinde nodül boyutunda boynun sağ tarafında %50’den daha büyük bir azalma olduğu ve sol taraftaki nodülün kaybolduğu görüldü. Sonuç olarak, radyofrekans ablasyon, papiller tiroid kanseri metastazı nedeniyle sekonder cerrahi gerektiren hastalarda metastatik lenf nodlarının tedavisi için güvenli ve uygulanabilir bir tekniktir.