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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Thermal immersion in managing greater weever sting: A case study on delayed recovery(Turkish Assoc Trauma Emergency Surgery, 2024) Eyinç, Erim; N/A; Aslan, Lercan; Gökdemir, Erdinç; Çalışkan, Emrah; School of Medicine; Koç University HospitalWe report the case of a 49-year-old woman who suffered an envenomation from a greater weever during a seaside vacation along the Aegean coast in Izmir, Türkiye. Following the incident, she experienced intense pain and sought treatment at an emergency department, where she received analgesics and cold compresses. Unfortunately, this approach failed to alleviate her pain, which persisted for approximately 24 hours. On the twelfth day, with symptoms worsening and the emergence of a larger wound than the one sustained on the day of the incident, she visited the University Hospital for further care, where she received periodic wound cleaning and a six-week antibiotic treatment regimen for possible osteomyelitis after suspicious findings on her Magnetic Resonance Imaging. The standard treatment for piscine envenomation involves hot water immersion to neutralize thermolabile toxins, providing pain relief and preventing subsequent complications. The water temperature should be between 40 and 45 degrees Celsius, and the affected body part should be immersed for at least 60 minutes. This case underscores the critical nature of hot water immersion in managing envenomation, a step which, if omitted, can result in extended pain duration and the evolution of a wound requiring over five months to heal.Publication Metadata only Complementary and alternative medicine use in breast cancer patients in Europe(Springer, 2024) Molassiotis, Alexander; Scott, Julia A.; Kearney, Nora; Pud, Dorit; Magri, Miriam; Selvekerova, Sarka; Bruyns, Ingrid; Fernandez-Ortega, Paz; Panteli, Vassiliki; Margulies, Anita; Gudmundsdottir, Gudbjorg; Milovics, Ljiljana; Ozden, Gulten; Patiraki, Elisabeth; Platin, Nurgün; School of NursingComplementary and alternative medicine (CAM) has gained popularity among cancer patients in the past years. For this study, CAM includes any group of health care systems, practices or products that are not considered to be part of conventional medicine at present (National Center for Complementary and Alternative Medicine). The present study assessed patterns of CAM use in breast cancer patients in Europe. The study used a descriptive cross-sectional design, and data were collected through a 27-item questionnaire. The sample, which was part of a larger study, consisted of 282 breast cancer patients from 11 countries in Europe. Among participants, 44.7% used CAM since their diagnosis of cancer. The most common therapies used included herbal medicine (46.4%) and medicinal teas, relaxation techniques, spiritual therapies, homeopathy and vitamins/minerals. Younger patients with higher education and who had received combination treatments for their cancer in the past were more likely to use CAM. High levels of satisfaction were reported, with only 6.5% of the women reporting no benefits from the CAM used. Main sources of information about CAM were mostly friends/family and the media. Findings suggested that a high proportion of breast cancer patients used CAM, which may have implications for the clinical management of these patients.Publication Metadata only Using Auger transitions as a route to determine the oxidation state of copper in high-pressure electron spectroscopy(Elsevier, 2024) Soldemo, Markus; Garcia-Martinez, Fernando; Goodwin, Christopher M.; Loemker, Patrick; Shipilin, Mikhail; Nilsson, Anders; Amann, Peter; Weissenrieder, Jonas; Department of Chemistry; Kaya, Sarp; Department of Chemistry; Koç University Tüpraş Energy Center (KUTEM); College of SciencesAccurate discrimination between metallic copper (Cu0) and cuprous oxide (Cu2O, Cu+) in electron spectroscopy commonly relies on the Auger electron spectroscopy (AES) Cu L3M4,5M4,5 transitions, as the X-ray photoelectron spectroscopy (XPS) Cu core-levels do not provide large enough binding energy shifts. The kinetic energy of the AES Cu L3M4,5M4,5 electrons is 917 eV, which leaves the AES electron susceptible for efficient scattering in the gas phase and attenuation of the signal above near-ambient pressure conditions. To study copper-based materials at higher pressures, e.g., the active state of a catalyst, Auger transitions providing electrons with higher kinetic energies are needed. This study focuses on AES transitions involving the Cu K-shell (1s electrons) that exhibit discernible kinetic energy shifts between the oxidation states of Cu. It is shown that the AES Cu KL2M4,5 transition, with kinetic energy of 7936 eV, provides a large enough kinetic energy shift between metallic copper and Cu2O. AES signal is demonstrated in an ambient of 150 mbar CO2.Publication Metadata only Effect of metformin on thyroid cancer risk in patients with acromegaly: a preliminary observational study(Churchill Livingstone, 2022) Sulu, Cem; Guzel, Suleyman Sami; Tay, Kubilay; Sahin, Serdar; Durcan, Emre; Ozkaya, Hande Mefkure; Kadioglu, Pinar; N/A; Bektaş, Ayyüce Begüm; PhD Student; Graduate School of Sciences and Engineering; N/APurpose: To evaluate the role of metformin on thyroid cancer risk in patients with acromegaly. Methods: Medical charts of 534 patients with acromegaly that were followed-up between 1983 and 2019 were reviewed. Patients with follow-up duration at least 6 months were included. Cohort entry was defined as first visit date. The date of each case's thyroid cancer diagnosis was defined as index date. Patients were followed until the index date, death, or last visit date, whichever came first. Nested case-control study design was selected to evaluate the association between metformin and the thyroid cancer risk in patients with acromegaly. Results: 291 patients with acromegaly were included into final analysis. The mean age at acromegaly diagnosis was 42.3 +/- 1.3 years. The median follow-up duration was 76 [34-132] months. Among 291 patients, 13 patients (4.5%) had thyroid cancer. Thirty-one percent (n = 92) of the patients used metformin for 6 months or longer. One standard deviation (SD) increase in average growth hormone increased the odds of having thyroid cancer by 1.164 folds (p = 0.017). One SD increase of the average insulin-like growth factor 1 to upper limit of normal ratio increased the odds of having thyroid cancer by 1.201 folds (p = 0.004). If a patient used metformin for at least 6 months, the odds to have thyroid cancer was decreased, multiplied by 0.62 with a 95% confidence interval of [0.47, 0.83] (p = 0.0013). The risk of thyroid cancer decreased with increasing duration of metformin use. Conclusion: Metformin may decrease the thyroid cancer risk in patients with acromegaly.Publication Metadata only Effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin, anti thyroid peroxidase and TSH in Rat(Walter De Gruyter Gmbh, 2018) Samadi, Afshin; Ansari, Mohammad Hassan Khadem; Ulusu, Nuriye Nuray; Faculty Member; School of Medicine; 6807Background: A large number of psychotropic drugs can interfere with the thyroid physiology, function and autoimmunity. Objective: The aim of the present study was to investigate the effects of alprazolam and haloperidol on thyroglobulin, antithyroglobulin (aTg), antithyroid peroxidase, and thyroid stimulating hormone levels on rats. Materials and Methods: First group of adult male Wistar rats was the control, second group received 0.5 mg kg(-1) haloperidol in physiological saline and the third group received 0.5 mg kg(-1) alprazolam, via gastric gavage once daily for 28 days. Plasma levels of all thyroid function tests were measured with chemiluminescent assay. Results: We have investigated a decrease in aTg amounts of control group (5.461 +/- 0.718) compared with drug treated rats with alprazolam (1.433 +/- 0.225) and haloperidol (1.21 +/- 0.228). (P-aTg = 0.00([ALP]), P-aTg = 0.01([HAL])). Although there were not any change in thyroglobulin levels in the haloperidol treated groups (0.9583 +/- 0.014) relative to control group (0.975 +/- 0.015); but in opposition Tg levels decreased significantly in response to alprazolam (0.36 +/- 0.16) compared with the control group (0.975 +/- 0.015), p-values are (P-Tg = 0. 001([ALP])), (P-Tg = 0. 021([HAL])). Conclusion: We found that these two drugs may interfere with the thyroid physiology and metabolism.Publication Metadata only Trans-Atlantic equity volatility connectedness: U.S. and European financial institutions, 2004-2014(Oxford Univ Press, 2016) Diebold, Francis X.; Department of Economics; Yılmaz, Kamil; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 6111We characterize equity return volatility connectedness in the network of major American and European financial institutions, 2004-2014. Our methods enable precise characterization of the timing and evolution of key aspects of the financial crisis. First, we find that during 2007-2008 the direction of connectedness was clearly from the United States to Europe, but that connectedness became bidirectional starting in late 2008. Second, we find an unprecedented surge in directional connectedness from European to U.S. financial institutions in June 2011, consistent with massive deterioration in the health of EU financial institutions. Third, we identify particular institutions that played disproportionately important roles in generating connectedness during the U.S. and the European crises.Publication Metadata only Humoral response to SARS-COV-2 MRNA vaccination in previous non-responder kidney transplant recipients after short-term withdrawal of mycophenolic acid(Frontiers, 2022) Benning, Louise; Morath, Christian; Kühn, Tessa; Bartenschlager, Marie; Kim, Heeyoung; Beimler, Joerg; Buylaert, Mirabel; Nusshag, Christian; Kälble, Florian; Reineke, Marvin; Töllner, Maximilian; Schaier, Matthias; Klein, Katrin; Blank, Antje; Schnitzler, Paul; Zeier, Martin; Bartenschlager, Ralf; Thuong Hien Tran; Speer, Claudius; Süsal, Caner; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Koç University Hospital; 351800Seroconversion rates after COVID-19 vaccination are significantly lower in kidney transplant recipients compared to healthy cohorts. Adaptive immunization strategies are needed to protect these patients from COVID-19. In this prospective observational cohort study, we enrolled 76 kidney transplant recipients with no seroresponse after at least three COVID-19 vaccinations to receive an additional mRNA-1273 vaccination (full dose, 100 mu g). Mycophenolic acid was withdrawn in 43 selected patients 5-7 days prior to vaccination and remained paused for 4 additional weeks after vaccination. SARS-CoV-2-specific antibodies and neutralization of the delta and omicron variants were determined using a live-virus assay 4 weeks after vaccination. In patients with temporary mycophenolic acid withdrawal, donor-specific anti-HLA antibodies and donor-derived cell-free DNA were monitored before withdrawal and at follow-up. SARS-CoV-2 specific antibodies significantly increased in kidney transplant recipients after additional COVID-19 vaccination. The effect was most pronounced in individuals in whom mycophenolic acid was withdrawn during vaccination. Higher SARS-CoV-2 specific antibody titers were associated with better neutralization of SARS-CoV-2 delta and omicron variants. In patients with short-term withdrawal of mycophenolic acid, graft function and donor-derived cell-free DNA remained stable. No acute rejection episode occurred during short-term follow-up. However, resurgence of prior anti-HLA donor-specific antibodies was detected in 7 patients.Publication Metadata only A resilient landscape: the land walls of constantinople and their surroundings(Christian Archaeological Soc, 2018) Department of Archeology and History of Art; Ricci, Alessandra; Faculty Member; Department of Archeology and History of Art; College of Social Sciences and Humanities; 41889The land walls of Constantinople, built in the early years of the 5th century, substantially reinforced the city's defenses while contributing to the creation of the capital's urban identity. This paper considers a rarely touched-upon subject, that of the usage of agricultural spaces within the land walls and their immediate vicinity. The presence of horticultural activities noted along present-day sections of the land walls represents the intangible memory of patterns of usage now traceable to the Late Antique period.Publication Metadata only Policy priorities in the election manifestos of political parties in Turkey, 2002-2015(İstanbul Üniversitesi, 2017) Department of International Relations; Aytaç, Selim Erdem; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 224278The policy areas prioritized by the major Turkish political parties during the election campaigns between 2002 and 2015 are examined in this study. The main questions to be addressed are as follows: Which policy areas do the political parties prioritize? Is there a significant divergence in the prioritization of different policy areas or are there common themes that are emphasized by all parties? Are there trends regarding the parties’ policy priorities over time? and finally, do the policy areas, as prioritized by the parties, correspond to what the public considers as important issues? To address these questions, the election manifestos of the four major Turkish political parties are analyzed. The analyses show that policy areas related to the economy, welfare, and quality of life are the most recurring themes in the election manifestos of the four major Turkish parties between 2002 and 2015.Publication Metadata only Performance measures for video object segmentation and tracking(IEEE-Inst Electrical Electronics Engineers Inc, 2004) Erdem, Çiğdem Eroğlu; Sankur, Bülent; Department of Electrical and Electronics Engineering; Tekalp, Ahmet Murat; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; 26207We propose measures to evaluate quantitatively the performance of video object segmentation and tracking methods without ground-truth (GT) segmentation maps. The proposed measures are based on spatial differences of color and motion along the boundary of the estimated video object plane and temporal differences between the color histogram of the current object plane and its predecessors. They can be used to localize (spatially and/or temporally) regions where segmentation results are good or bad; and/or they can be combined to yield a single numerical measure to indicate the goodness of the boundary segmentation and tracking results over a sequence. The validity of the proposed performance measures without GT have been demonstrated by canonical correlation analysis with another set of measures with GT on a set of sequences (where GT information is available). Experimental results are presented to evaluate the segmentation maps obtained from various sequences using different segmentation approaches.