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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Unguales plattenepithelkarzinom bei einem patienten mit mal de meleda(Wiley, 2016) Baykal, Can; Sarı, Şule Öztürk; Uyguner, Zehra Oya; Ekinci, Algun Polat; Demir, Özgür; Babuna, Goncagül; Büyükbabani, Nesimi; N/A; Kayserili, Hülya; Faculty Member; School of Medicine; 7945N/APublication Metadata only Counterexamples to regularity of Mane projections in the theory of attractors(Institute of Physics (IOP) Publishing, 2013) Eden, Alp; Zelik, Sergey V.; Department of Mathematics; Kalantarov, Varga; Faculty Member; Department of Mathematics; College of Sciences; 117655This paper is a study of global attractors of abstract semilinear parabolic equations and their embeddings in finite-dimensional manifolds. As is well known, a sufficient condition for the existence of smooth (at least C-1-smooth) finite-dimensional inertial manifolds containing a global attractor is the so-called spectral gap condition for the corresponding linear operator. There are also a number of examples showing that if there is no gap in the spectrum, then a C-1-smooth inertial manifold may not exist. on the other hand, since an attractor usually has finite fractal dimension, by Mane's theorem it projects bijectively and Holder-homeomorphically into a finite-dimensional generic plane if its dimension is large enough. It is shown here that if there are no gaps in the spectrum, then there exist attractors that cannot be embedded in any Lipschitz or even log-Lipschitz finite-dimensional manifold. Thus, if there are no gaps in the spectrum, then in the general case the inverse Mane projection of the attractor cannot be expected to be Lipschitz or log-Lipschitz. Furthermore, examples of attractors with finite Hausdorff and infinite fractal dimension are constructed in the class of non-linearities of finite smoothness.Publication Metadata only Direct identification of A-to-I editing sites with nanopore native RNA sequencing(NATURE PORTFOLIO, 2022) Nguyen, Tram Anh; Heng, Jia Wei Joel; Kaewsapsak, Pornchai; Kok, Eng Piew Louis; Stanojevic, Dominik; Liu, Hao; Cardilla, Angelysia; Praditya, Albert; Yi, Zirong; Lin, Mingwan; Aw, Jong Ghut Ashley; Ho, Yin Ying; Peh, Kai Lay Esther; Wang, Yuanming; Zhong, Qixing; Heraud-Farlow, Jacki; Xue, Shifeng; Walkley, Carl; Ho, Ying Swan; Sikic, Mile; Wan, Yue; Tan, Meng How; N/A; Reversade, Bruno; Faculty Member; School of Medicine; 274182Inosine is a prevalent RNA modification in animals and is formed when an adenosine is deaminated by the ADAR family of enzymes. Traditionally, inosines are identified indirectly as variants from Illumina RNA-sequencing data because they are interpreted as guanosines by cellular machineries. However, this indirect method performs poorly in protein-coding regions where exons are typically short, in non-model organisms with sparsely annotated single-nucleotide polymorphisms, or in disease contexts where unknown DNA mutations are pervasive. Here, we show that Oxford Nanopore direct RNA sequencing can be used to identify inosine-containing sites in native transcriptomes with high accuracy. We trained convolutional neural network models to distinguish inosine from adenosine and guanosine, and to estimate the modification rate at each editing site. Furthermore, we demonstrated their utility on the transcriptomes of human, mouse and Xenopus. Our approach expands the toolkit for studying adenosine-to-inosine editing and can be further extended to investigate other RNA modifications.Publication Metadata only Contact mechanics between the human finger and a touchscreen under electroadhesion(Natl Acad Sciences, 2018) Scaraggi, Michele; Persson, Bo N. J.; N/A; N/A; Department of Mechanical Engineering; Ayyıldız, Mehmet; Şirin, Ömer; Başdoğan, Çağatay; Researcher; PhD Student; Faculty Member; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; Graduate School of Sciences and Engineering; College of Engineering; N/A; N/A; 125489The understanding and control of human skin contact against technological substrates is the key aspect behind the design of several electromechanical devices. Among these, surface haptic displays that modulate the friction between the human finger and touch surface are emerging as user interfaces. One such modulation can be achieved by applying an alternating voltage to the conducting layer of a capacitive touchscreen to control electroadhesion between its surface and the finger pad. However, the nature of the contact interactions between the fingertip and the touchscreen under electroadhesion and the effects of confined material properties, such as layering and inelastic deformation of the stratum corneum, on the friction force are not completely understood yet. Here, we use a mean field theory based on multiscale contact mechanics to investigate the effect of electroadhesion on sliding friction and the dependency of the finger-touchscreen interaction on the applied voltage and other physical parameters. We present experimental results on how the friction between a finger and a touchscreen depends on the electrostatic attraction between them. The proposed model is successfully validated against full-scale (but computationally demanding) contact mechanics simulations and the experimental data. Our study shows that electroadhesion causes an increase in the real contact area at the microscopic level, leading to an increase in the electrovibrating tangential frictional force. We find that it should be possible to further augment the friction force, and thus the human tactile sensing, by using a thinner insulating film on the touchscreen than used in current devices.Publication Metadata only How, when, and why do attribute-complementary versus attribute-similar cobrands affect brand evaluations: a concept combination perspective(Oxford Univ Press Inc, 2015) Swaminathan, Vanitha; Kubat, Umut; Department of Business Administration; N/A; Canlı, Zeynep Gürhan; Şanlı, Ceren Hayran; Faculty Member; PhD Student; Department of Business Administration; College of Administrative Sciences and Economics; Graduate School of Business; 16135; 275215Extant research on cobranding does not examine when and why complementarity or similarity between cobranding partners can be more effective. This research examines consumers' reactions to cobranded partnerships that feature brands with either complementary or similar attribute levels, both of which are common in the marketplace. The results of six experiments show that consumers' evaluations vary as a function of concept combination interpretation strategy (property mapping or relational linking) and whether cobranded partners have complementary or similar attributes. Specifically, when consumers use property mapping, they evaluate cobranded partnerships with complementary (vs. similar) attribute levels more favorably. In contrast, when using relational linking, they evaluate cobranded partnerships with complementary (vs. similar) attribute levels less favorably. The results also reveal that the breadth of the host brand (broad vs. narrow) and the type of advertising influence the extent to which consumers are likely to use property mapping or relational linking in evaluating cobranded partnerships.Publication Metadata only Multi-dimensional skills, specialization, and oligopolistic competition in higher education(Elsevier, 2010) Department of Economics; Sarpça, Sinan; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 52406This paper develops a differentiated products model of school competition that distinguishes among different dimensions that matter in the skill acquisition process. The model predicts that when identical schools compete for students, specialization may arise as a competition strategy. This serves rich students' education goals well. Poorer students, however, may attend schools with specializations that do not cater to their relative strengths. By doing so, these poorer students complement the weaknesses of the richer students through peer effects and receive financial aid in return. The empirical analysis provides strong support for the model's predictions about within-school implications of specialization.Publication Metadata only A physical channel model for nanoscale neuro-spike communications(IEEE-Inst Electrical Electronics Engineers Inc, 2013) Balevi, eren; Department of Electrical and Electronics Engineering; Akan, Özgür Barış; Faculty Member; Department of Electrical and Electronics Engineering; College of Engineering; 6647Nanoscale communications is an appealing domain in nanotechnology. Novel nanoscale communications techniques are currently being devised inspired by some naturally existing phenomena such as the molecular communications governing cellular signaling mechanisms. Among these, neuro-spike communications, which governs the communications between neurons, is a vastly unexplored area. The ultimate goal of this paper is to accurately investigate nanoscale neuro-spike communications characteristics through the development of a realistic physical channel model between two neurons. The neuro-spike communications channel is analyzed based on the probability of error and delay in spike detection at the output. The derived communication theoretical channel model may help designing novel artificial nanoscale communications methods for the realization of future practical nanonetworks, which are the interconnections of nanomachines.Publication Metadata only The effect of strut protrusion on local shear stress and neointimal hyperplasia(Oxford University Press (OUP), 2019) Tenekecioglu, E.; Katagiri, Y.; Torii, R.; Onuma, Y.; Serruys, P. W.; Department of Mechanical Engineering; Pekkan, Kerem; Faculty Member; Department of Mechanical Engineering; College of Engineering; 161845N/APublication Metadata only A new dataset of non-redundant protein/protein interfaces(Biophysical Society, 2003) Tsai, CJ; Wolfson, H; Nussinov, R; Department of Chemical and Biological Engineering; Keskin, Özlem; Faculty Member; Department of Chemical and Biological Engineering; College of Engineering; 26605Publication Metadata only Continuous dependence for the convective brinkman–forchheimer equations(Taylor & Francis, 2005) Çelebi, A.O.; Ugurlu, D.; Department of Mathematics; Kalantarov, Varga; Faculty Member; Department of Mathematics; College of Sciences; 117655In this article, we have considered the convective Brinkman–Forchheimer equations with Dirichlet's boundary conditions. The continuous dependence of solutions on the Forchheimer coefficient in H 1 norm is proved.