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Publication Metadata only How does poverty stigma affect depression symptoms for women living with HIV? longitudinal mediating and moderating mechanisms(Springer, 2023) Kempf, Mirjam-Colette; Konkle-Parker, Deborah; Wilson, Tracey E.; Tien, Phyllis C.; Wingood, Gina; Neilands, Torsten B.; Johnson, Mallory O.; Logie, Carmen H.; Weiser, Sheri D.; Department of Psychology; Turan, Bülent; Turan, Janet Molzan; Department of Psychology; College of Social Sciences and Humanities; School of MedicineIn a sample of women living with HIV, we examined whether individual traits fear of negative evaluation and resilience moderate the internalization of poverty stigma that these women experience from others. We also examined the downstream effects of these processes on depression symptoms using moderated serial mediation analyses. Data were collected annually for 4 years (2016-2020; T1, T2, T3, and T4) from 369 women living with HIV at 4 US cities using validated measures. Moderation effects were evaluated examining simple slopes at one standard deviation above and below the mean of the moderator. In all mediation analyses utilizing bootstrapping, we used the independent variable measured at T1, the mediators measured at subsequent visits (T2 and T3), and the outcome at the last visit (T4) to preserve the temporal sequence among the independent variable, mediators, and outcome variable. We also adjusted for T1 values of all mediators and outcome variables in analyses. Women with stronger fears of negative evaluation by others or lower dispositional resilience had stronger associations between experienced poverty stigma and internalized poverty stigma. Internalized poverty stigma (T2) mediated the association between experienced poverty stigma (T1) and depression symptoms (T4); this mediated association was moderated by fear of negative evaluation and resilience (T1). Finally, internalized poverty stigma (T2) and avoidance coping (T3) were serial mediators in the association between experienced poverty stigma (T1) and depression symptoms (T4), moderated by fear of negative evaluation and resilience. Understanding factors that minimize internalization of stigma and buffer its negative effects on mental health can inform interventions to improve health outcomes of individuals with stigmatized conditions.Publication Metadata only T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV(Elsevier, 2022) Williams, Dionna W.; Flores, Bianca R.; Xu, Yanxun; Wang, Yuezhe; Yu, Danyang; Peters, Brandilyn A.; Adedimeji, Adebola; Wilson, Tracey E.; Merenstein, Daniel; Tien, Phyllis C.; Cohen, Mardge H.; Weber, Kathleen M.; Adimora, Adaora A.; Ofotokun, Igho; Fischl, Margaret; Turan, Janet; Laumet, Geoffroy; Landay, Alan L.; Dastgheyb, Raha M.; Gange, Stephen J.; Weiser, Sheri D.; Rubin, Leah H.; Department of Psychology; Turan, Bülent; Department of Psychology; College of Social Sciences and HumanitiesNeuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/<20cp/mL) enrolled in the Women's Interagency HIV Study completed neuropsychological testing and measures of depression (Center for Epidemiological Studies Depression Scale-CES-D), self-reported stress levels (Perceived Stress Scale-10), and post-traumatic stress (PTSD Checklist-Civilian Scale). Multiparametric flow cytometry evaluated T-cell activation state. Partial least squares regressions were used to examine T-cell phenotypes and neuropsychiatric outcome associations after confounder adjustment. In the total sample and among virally suppressed (VS)-WWH, CD4(+) T-cell exhaustion was associated with poorer learning and attention/working memory (P's < 0.05). In the total sample, CD4(+) T-cell activation was associated with better attention/working memory and CD8(+) T-cell co-stimulation and senescence was associated with poorer executive function (P's < 0.05). For mental health outcomes, in the total sample, CD4(+) T-cell activation was associated with more perceived stress and CD4(+) T-cell exhaustion was associated with less depressive symptoms (P's < 0.05). Among VS-WWH, CD4(+) senescence was associated with less perceive stress and CD8(+) T-cell co-stimulation and senescence was associated with higher depression (P's < 0.05). Together, results suggest the contribution of peripheral CD4(+) and CD8(+) T-cell activation status to neuropsychiatric complications in WWH.Publication Metadata only Correction: oxidatively-induced DNA base damage and base excision repair abnormalities in siblings of individuals with bipolar disorder DNA damage and repair in bipolar disorder(Springer Nature, 2024) Çelik, Hidayet Ece Arat; Yilmaz, Selda; Aksahin, Izel Cemre; Kendirlioglu, Burcu Kok; Corekli, Esma; Dal Bekar, Nazli Ecem; Celik, Omer Faruk; Yorguner, Nese; Ozturk, Bilge Targitay; Islekel, Huray; Ozerdem, Aysegul; Tuna, Gam; Akşahin, İzel Cemre; Ceylan, Deniz; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; School of MedicineCorrection to: Translational Psychiatryhttps://doi.org/10.1038/s41398-024-02901-3, published online 24 May 2024 In this article the funding from ‘[2021.KB.SAG.047]’ was omitted. The corrected acknowledgment should read: This research was funded by the Dokuz Eylul University Scientific Research Project Scholarship (2021.KB.SAG.047) and LithiumAssociation Scholarship. The original article has been corrected.Publication Metadata only Childhood maltreatment is linked to larger preferred interpersonal distances towards friends and strangers across the globe(SpringerNature, 2024) Haim-Nachum, Shilat; Sopp, Marie R.; Luond, Antonia M.; Afzal, Nimrah; Ahs, Fredrik; Allgaier, Antje-Kathrin; Arevalo, Adrian; Asongwe, Christian; Bachem, Rahel; Balle, Stefanie R.; Belete, Habte; Belete Mossie, Tilahun; Berzengi, Azi; Capraz, Necip; Dukes, Daniel; Essadek, Aziz; Fares-Otero, Natalia E.; Halligan, Sarah L.; Hemi, Alla; Iqbal, Naved; Jobson, Laura; Levy-Gigi, Einat; Martin-Soelch, Chantal; Michael, Tanja; Oe, Misari; Olff, Miranda; Oernkloo, Helena; Prakash, Krithika; Quaatz, Sarah M.; Raghavan, Vijaya; Ramakrishnan, Muniarajan; Reis, Dorota; Schnyder, Ulrich; Seedat, Soraya; Shihab, Ibtihal Najm; Vandhana, Susilkumar; Wadji, Dany Laure; Wamser, Rachel; Zabag, Reut; Spies, Georgina; Pfaltz, Monique C.; N/A; Şar, Vedat; Ceylan, Deniz; School of Medicine; Koç University HospitalChildhood maltreatment (CM) is thought to be associated with altered responses to social stimuli and interpersonal signals. However, limited evidence exists that CM is linked to larger comfortable interpersonal distance (CID) - the physical distance humans prefer towards others during social interactions. However, no previous study has investigated this association in a comprehensive sample, yielding sufficient statistical power. Moreover, preliminary findings are limited to the European region. Finally, it is unclear how CM affects CID towards different interaction partners, and whether CID is linked to social functioning and attachment. To address these outstanding issues, adults (N = 2986) from diverse cultures and socio-economic strata completed a reaction time task measuring CID towards an approaching stranger and friend. Higher CM was linked to a larger CID towards both friends and strangers. Moreover, insecure attachment and less social support were associated with larger CID. These findings demonstrate for the first time that CM affects CID across countries and cultures, highlighting the robustness of this association.Publication Metadata only Oxidatively-induced DNA base damage and base excision repair abnormalities in siblings of individuals with bipolar disorder DNA damage and repair in bipolar disorder(SpringerNature, 2024) Celik, Hidayet Ece Arat; Yilmaz, Selda; Kendirlioglu, Burcu Kok; Corekli, Esma; Dal Bekar, Nazli Ecem; Celik, Omer Faruk; Yorguner, Nese; Oztuerk, Bilge Targitay; Islekel, Hueray; Ozerdem, Ayseguel; Akan, Pinar; Tuna, Gamze; N/A; Akşahin, İzel Cemre; Ceylan, Deniz; Koç University Research Center for Translational Medicine (KUTTAM); School of Medicine; Graduate School of Health Sciences; Koç University HospitalPrevious evidence suggests elevated levels of oxidatively-induced DNA damage, particularly 8-hydroxy-2'-deoxyguanosine (8-OH-dG), and abnormalities in the repair of 8-OH-dG by the base excision repair (BER) in bipolar disorder (BD). However, the genetic disposition of these abnormalities remains unknown. In this study, we aimed to investigate the levels of oxidatively-induced DNA damage and BER mechanisms in individuals with BD and their siblings, as compared to healthy controls (HCs). 46 individuals with BD, 41 siblings of individuals with BD, and 51 HCs were included in the study. Liquid chromatography-tandem mass spectrometry was employed to evaluate the levels of 8-OH-dG in urine, which were then normalized based on urine creatinine levels. The real-time-polymerase chain reaction was used to measure the expression levels of 8-oxoguanine DNA glycosylase 1 (OGG1), apurinic/apyrimidinic endonuclease 1 (APE1), poly ADP-ribose polymerase 1 (PARP1), and DNA polymerase beta (POL beta). The levels of 8-OH-dG were found to be elevated in both individuals with BD and their siblings when compared to the HCs. The OGG1 and APE1 expressions were downregulated, while POL beta expressions were upregulated in both the patient and sibling groups compared to the HCs. Age, smoking status, and the number of depressive episodes had an impact on APE1 expression levels in the patient group while body mass index, smoking status, and past psychiatric history had an impact on 8-OH-dG levels in siblings. Both individuals with BD and unaffected siblings presented similar abnormalities regarding oxidatively-induced DNA damage and BER, suggesting a link between abnormalities in DNA damage/BER mechanisms and familial susceptibility to BD. Our findings suggest that targeting the oxidatively-induced DNA damage and BER pathway could offer promising therapeutic strategies for reducing the risk of age-related diseases and comorbidities in individuals with a genetic predisposition to BD.Publication Metadata only Mental health and support 1 year after the earthquakes in Türkiye(Elsevier Ltd, 2024) Kurt, Gulsah; Erşahin, Merve; Aker, A Tamer; Uygun, Ersin; Department of Psychology; Acartürk, Ceren; Department of Psychology; College of Social Sciences and HumanitiesN/APublication Metadata only Effect of clozapine on suicidality in patients with schizophrenia at a university hospital in Turkey(Elsevier B.V., 2023) Gürcan, Gamze; Yağcıoğlu, A. Elif Anıl; Ertuğrul, Aygün; Koç University Hospital[No abstract available]Publication Metadata only The emotion of disgust is associated with pediatric OCD depending on the level of harm avoidance(Elsevier Science Inc, 2023) Walia, Gurpreet Singh; Cheng, Szu-Chi; Cepeda, Ximena Cors; Vega, Catalina De Leon; Atahanov, Kerim; Grados, Marco A.; Bakır, Çiçek Nur; School of MedicineObjectives: The emotion of disgust is a risk factor for obsessive-compulsive symptoms and traits. The role of the temperamental trait of harm avoidance, which predisposes to heightened anxiety, in mediating this relationship has not been studied in youth. This study examines the role harm avoidance in modulating the association of disgust with OCD. Methods: A pediatric OCD registry enrolled 59 youth with OCD, Tourette’s disorder, ADHD, or anxiety disorders. Disgust was measured using the Children’s Disgust Scale (CDS), an 18-item normed quantitative scale divided into affective disgust and avoidance disgust. The Leyton Obsessional Inventory Child Version (LOI-CV), a 20-item self-report measure, assessed obsessive-compulsive symptoms/traits. Median-split high-low LOI-CV groups and LOI-CV subscales (LOI-obsessions, LOI-contamination, LOI-numbers, LOI-perfectionism) were created. Harm avoidance was derived from the Junior Temperament and Character Inventory (JTCI), a 108-item parent self-report assay. Student t tests compared disgust total, affective, and avoidance scores in high-low LOI-CV groups and subscales. High-low harm avoidance groups were used to repeat the analyses, to determine if harm avoidance levels influence results. Results: A total of 59 youth ages 7 to 17 years (12.9 ± 2.8), 44% female, and 79% White formed low LOI-CV (n = 31) and high LOI-CV (n = 28) groups. Affective disgust ( p = .01), avoidance disgust ( p = .06), and total disgust scores ( p = .009) are significantly higher in the high LOI-CV stratum. Three subscales are also higher in the high LOI-CV group: LOI-obsessions ( p = .03), LOI-contamination ( p = .002), and LOI-perfectionism ( p = .02). When divided into harm avoidance strata, the high harm avoidance stratum had significant LOI-CV total ( p = .06) and LOI-contamination ( p = .001), while the low harm avoidance stratum had significant LOI-contamination ( p = .01) and LOI-perfectionism ( p = .03). Conclusions: Disgust measures are associated with LOI-CV obsessive-compulsive symptoms/traits across all LOI-CV subscales. However, high harm avoidance is more strongly associated with LOI-contamination (symptom), whereas low harm avoidance is associated with perfectionism (trait). Harm avoidance modulates the relationship between disgust and OCD symptoms/traits.Publication Metadata only Storytelling used in combination to a relaxing virtual reality experience for children with cancer: a feasibility study(Elsevier Science Inc, 2023) Konakci, Belgin; Bakır, Çiçek Nur; Canbaz, Ata Alpay; Erden, Selin Ece; Genç, Herdem Aslan; Mutluer, Tuba; School of Medicine; Koç University HospitalObjectives: Complementary treatments as a distraction in medical procedures are used in pediatric oncology patients because they are subjected to anxiety and distress. This study examined the feasibility of virtual reality (VR) and storytelling as a distraction and relaxation for children with cancer. Methods: Patients aged 6 to 17 years speaking fluent Turkish, having a diagnosis or recurrence of cancer (with no central nervous system involvement) within a year, and receiving chemotherapy for more than a month, were recruited. Baseline tests were given to children (Pediatric Quality of Life Inventory [PedsQL], Cancer Module and State-Trait Anxiety Inventory for Children) and parents (PedsQL-parent module and Child Behavior Checklist [CBCL]). Participants either received a 7-minute immersive wild dolphin VR session or VR and a 5-minute storytelling before or after the VR session for 4 sessions within a month. Visual analog scales (1-10 for nausea, fatigue, and distress) were used before and after the intervention. Results: Of 39 invited patients, 27 (70%) were interested (11.29 ± 3.55 years old; 48% female). Four patients dropped out of the study due to nausea, fatigue, and/or loss of interest. Fourteen patients were recruited to the storytelling group. Two patients were discharged from the hospital during the study. Forty-nine sessions were completed. Patients reported an average of 0.67 (±1.46), 0.43 (±1.76), and 0.24 (±0.76) points of decrease in their fatigue, distress, and nausea, respectively. Although there has not been an observed change in fatigue ( p = .32) and distress ( p = .32) between the VR-only and storytelling groups, there was a significant decrease in nausea (0.81 vs 2.41; p = .04). The majority of the participants mentioned to like (96%), recommend (92%), and be interested in repeating (80%) the intervention. Conclusions: This study demonstrated the feasibility of combining storytelling with VR as a distraction and relaxation method in decreasing distress, nausea, and fatigue in pediatric oncology patients. The results demonstrated that children adhere to the VR experience with storytelling, and likability of the intervention is high with potential benefits. Further explorations of these techniques may lead to more effective and personalized strategies to support the well-being of these patients.Publication Metadata only Routine CSF parameters as predictors of disease course in multiple sclerosis: an MSBase cohort study(BMJ Publishing Group, 2024) Dekeyser, Catherine; Hautekeete, Matthias; Cambron, Melissa; Van Pesch, Vincent; Patti, Francesco; Kuhle, Jens; Khoury, Samia; Scott, Jeanette Lechner; Gerlach, Oliver; Lugaresi, Alessandra; Maimone, Davide; Surcinelli, Andrea; Grammond, Pierre; Kalincik, Tomas; Habek, Mario; Willekens, Barbara; Macdonell, Richard; Lalive, Patrice; Csepany, Tunde; Butzkueven, Helmut; Boz, Cavit; Tomassini, Valentina; Foschi, Matteo; Sanchez-Menoyo, Jose Luis; Mrabet, Saloua; Iuliano, Gerardo; Sa, Maria Jose; Alroughani, Raed; Karabudak, Rana; Aguera-Morales, Eduardo; Gray, Orla; de Gans, Koen; van der Walt, Anneke; McCombe, Pamela A.; Deri, Norma; Garber, Justin; Al-Asmi, Abdullah; Skibina, Olga; Duquette, Pierre; Cartechini, Elisabetta; Spitaleri, Daniele; Gouider, Riadh; Soysal, Aysun; Van Hijfte, Liesbeth; Slee, Mark; Amato, Maria Pia; Buzzard, Katherine; Laureys, Guy; Altıntaş, Ayşe; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of MedicineBackground It remains unclear whether routine cerebrospinal fluid (CSF) parameters can serve as predictors of multiple sclerosis (MS) disease course.Methods This large-scale cohort study included persons with MS with CSF data documented in the MSBase registry. CSF parameters to predict time to reach confirmed Expanded Disability Status Scale (EDSS) scores 4, 6 and 7 and annualised relapse rate in the first 2 years after diagnosis (ARR2) were assessed using (cox) regression analysis.Results In total, 11 245 participants were included of which 93.7% (n=10 533) were persons with relapsing-remitting MS (RRMS). In RRMS, the presence of CSF oligoclonal bands (OCBs) was associated with shorter time to disability milestones EDSS 4 (adjusted HR=1.272 (95% CI, 1.089 to 1.485), p=0.002), EDSS 6 (HR=1.314 (95% CI, 1.062 to 1.626), p=0.012) and EDSS 7 (HR=1.686 (95% CI, 1.111 to 2.558), p=0.014). On the other hand, the presence of CSF pleocytosis (>= 5 cells/mu L) increased time to moderate disability (EDSS 4) in RRMS (HR=0.774 (95% CI, 0.632 to 0.948), p=0.013). None of the CSF variables were associated with time to disability milestones in persons with primary progressive MS (PPMS). The presence of CSF pleocytosis increased ARR2 in RRMS (adjusted R2=0.036, p=0.015).Conclusions In RRMS, the presence of CSF OCBs predicts shorter time to disability milestones, whereas CSF pleocytosis could be protective. This could however not be found in PPMS. CSF pleocytosis is associated with short-term inflammatory disease activity in RRMS. CSF analysis provides prognostic information which could aid in clinical and therapeutic decision-making.