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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3

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Quartile: search.filters.quartile.Q4Subject: search.filters.subject.Reproductive biology

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    Understanding follicle growth in vitro: are we getting closer to obtaining mature oocytes from in vitro-grown follicles in human?
    (Wiley, 2017) Güzel, Yılmaz; N/A; Öktem, Özgür; Faculty Member; School of Medicine; 102627
    Obtaining and fertilizing mature oocytes from immature follicles that were grown outside the body has conceptually attracted scientists for centuries, with initial attempts first documented in the 19th century. Significant progress has been made since then, due in part to a better understanding of folliculogenesis and improved techniques of in vitro follicle growth. Indeed, in vitro growth is now considered a reasonable approach to preserve or restore fertility when immature follicles and their oocytes need to be grown and matured outside the body. Certain patients would benefit from in vitro follicle growth, particularly those who carry a risk of cancer re-seeding after grafting of frozen-thawed ovarian tissue or who are at the risk of premature ovarian failure due to several intrinsic ovarian defects and genetic mutations that lead to accelerated follicle atresia and early exhaustion of the ovarian reserve. This review provides an update on the current status of in vitro growth of preantral human follicles, from initial efforts to the most recent achievements.
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    Fertilisation and early embryonic development of immature and rescue in vitro-matured sibling oocytes
    (Taylor & Francis Inc, 2022) Avcı, Berrin; Özbay, Aysun; Kasapoğlu, Işıl; Çakır, Cihan; Uncu, Gürkan; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910
    The objective of this study was to assess the effect of rescue in vitro maturation and immediate intracytoplasmic sperm injection (ICSI) application on fertilisation success and early embryonic development of metaphase I (MI) oocytes. This was a retrospective cohort study including 2425 sibling oocytes in 259 ICSI cycles. ICSI was performed on 104 GV (germinal vesicle) oocytes which had reached the metaphase II (MII) stage (Group 1) and 231 MI oocytes which had reached the MII stage (Group 2) following IVM (in vitro maturation). Immediate ICSI was applied following oocyte aspiration on 292 MI stage (Group 3) and 1798 MII stage oocytes (Group 4). Normal fertilisation rates in Groups 1, 2, 3 and 4 were 51.9%, 39%, 30.1% and 59.5%, respectively. The rates of blastocyst development per oocyte and per zygote were calculated as 3.8%, 3.0%, 6.8%, 14.1% and 7.4%, 7.7%, 22.7%, 23.6% for Groups 1, 2, 3 and 4, respectively. The blastocyst development rate was significantly higher in the MI-ICSI group compared with other immature oocytes. Even though performing ICSI on the oocytes at the MI stage on the day of oocyte aspiration resulted in lower fertilisation rates, it was associated with significantly higher rates of blastocyst development.
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    The effects of CLP-induced sepsis on proliferation and apoptosis of granulosa and theca cells in rat ovary: a histochemical and ultrastructural study
    (Elsevier, 2020) Taşdemir, Müge; Ekiz-Yılmaz, Tuğba; Uğur-Yılmaz, Canan; Orhan, Nurcan; Doğan, Mehmet Ali; Arıcan, Nadir; N/A; Kaya, Mehmet; Ahıshalı, Bülent; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 10486; 9509
    Sepsis is defined as a systemic inflammatory response to infection. This study is aimed to evaluate the effects of experimental sepsis on the proliferation and apoptosis of granulosa and theca cells in the rat ovary.