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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Live birth following early follicular phase oocyte collection and vitrified-warmed embryo transfer 8 days later(Elsevier Sci Ltd, 2015) Hatirnaz, Safak; Hatirnaz, Ebru; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910A 30-year-old woman with premature ovarian insufficiency had two follicles measuring 17 mm and 14 mm on day 3 of her menstrual cycle. Serum oestradiol concentration was 210 pg/ml. Recombinant human chorionic gonadotrophin was given and 5 mg/day letrozole started orally. One metaphase II oocyte was collected 36 h later. A 4-cell embryo was vitrified on the second day after fertilization. Letrozole was stopped on cycle day 8 due to absence of any other visible antral follicles. Oestradiol valerate 6 mg/day was started and the endometrium was 9.2 mm on cycle day 11. The embryo was warmed and transferred on cycle day 13, the 8th day after oocyte retrieval. Luteal phase support with progesterone, oestradiol and low molecular weight heparin was started on the day of transfer and continued until the 10th gestational week. A healthy girl weighing 3200 g was born at term. Early follicular phase oocyte collection did not result in early opening of the implantation window. Apparently secretory transformation was not started until luteal phase support, enabling a cleavage stage embryo transferred 8 days later to implant. Either corpus luteum formation could be disrupted or the endometrium could remain unresponsive to progesterone during the early follicular phase.Publication Metadata only Strategies for controlled ovarian stimulation in the setting of ovarian aging(Thieme Medical Publ Inc, 2015) Seli, Emre; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910In the context of assisted reproduction, the term ovarian aging is often used to refer to declining potential of ovaries to produce oocytes in adequate number or quality in response to controlled ovarian stimulation (COS). Different aspects of COS have been modified with the intention to increase the number and quality of oocytes obtained for in vitro fertilization. In the setting of ovarian aging, suppression of the luteinizing hormone (LH) surge with gonadotropin-releasing hormone (GnRH) antagonist or short GnRH agonist protocol and stimulation with a daily gonadotropin dosage of300 IU/day seem to be appropriate first choices, and there is a strong need for well-designed randomized controlled trials investigating effects of addition of LH activity, estradiol priming, transdermal testosterone administration, and growth hormone supplementation. Given the lack of high-quality evidence showing effectiveness of one approach over another, other factors such as duration of stimulation, total gonadotropin consumption and cost of medication, patient friendliness, and possible side effect profiles must be considered in tailoring the COS protocol according to each individual's needs and desires.Publication Metadata only Additive manufacturing and three-dimensional printing in obstetrics and gynecology: a comprehensive review(Springer, 2023) Yaşlı, Mert; Dabbagh, Sajjad Rahmani; Taşoğlu, Savaş; Aydın, Serdar; Undergraduate Student; PhD Student; Faculty Member; Faculty Member; School of Medicine; Graduate School of Sciences and Engineering; School of Medicine; School of Medicine; N/A; N/A; N/A; Koç University Hospital; N/A; N/A; 291971; 132535Three-dimensional (3D) printing, also known as additive manufacturing, is a technology used to create complex 3D structures out of a digital model that can be almost any shape. Additive manufacturing allows the creation of customized, finely detailed constructs. Improvements in 3D printing, increased 3D printer availability, decreasing costs, development of biomaterials, and improved cell culture techniques have enabled complex, novel, and customized medical applications to develop. There have been rapid development and utilization of 3D printing technologies in orthopedics, dentistry, urology, reconstructive surgery, and other health care areas. Obstetrics and Gynecology (OBGYN) is an emerging application field for 3D printing. This technology can be utilized in OBGYN for preventive medicine, early diagnosis, and timely treatment of women-and-fetus-specific health issues. Moreover, 3D printed simulations of surgical procedures enable the training of physicians according to the needs of any given procedure. Herein, we summarize the technology and materials behind additive manufacturing and review the most recent advancements in the application of 3D printing in OBGYN studies, such as diagnosis, surgical planning, training, simulation, and customized prosthesis. Furthermore, we aim to give a future perspective on the integration of 3D printing and OBGYN applications and to provide insight into the potential applications.Publication Metadata only Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer)(Oxford Univ Press, 2018) Abou Setta, A.; Seyhan, A.; Buckett, W.; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 232576N/APublication Metadata only The effect of endometrial injury on implantation and clinical pregnancy rates(Taylor & Francis, 2017) Levin, Dan; Hasson, Joseph; Cohen, Aviad; Or, Yuval; Barzilay, Lilia; Almog, Benny; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 232576Aim: To assess the effect of endometrial scratching (ES) on in vitro fertilization-embryo transfer outcome (IVF-ET)Materials and methods: Retrospective matched case control study including all fresh IVF cycles performed between January 2006 and December 2012 at an academic IVF center. ES with an endometrial biopsy catheter was performed in the cycle preceding the index IVF cycle. Patients (n=238) were pair matched with controls according to age, number of previous failed IVF cycles and number of embryos transferred.Results: Demographic and cycle characteristics were comparable in all of the following: age, number of previous cycles, number of collected oocyte, number of embryos transferred and quality of transferred embryos. Implantation, clinical and ongoing pregnancy rates were comparable in both groups (28%, 34% and 18.4% vs 30%, 40.3% and 29%, in ES group and controls, respectively). Logistic regression analysis found no significant association between ES and pregnancy rate.Conclusions: Mechanical endometrial stimulation did not improve implantation and pregnancy rates. Furthermore, no factors that may predict which patients could benefit from ES were identified. Further prospective studies are warranted to evaluate possible benefits in different subsets of patients such as patients with recurrent implantation failures.Publication Metadata only Diagnostic accuracy of sentinel node biopsy in non-endometrioid, high-grade and/or deep myoinvasive endometrial cancer: a Turkish gynecologic oncology group study (TRSGO-SLN-006)(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2022) Altın, Duygu; Taşkın, Salih; Ortaç, Firat; Tokgözoğlu, Nedim; Güler, Abdul Hamid; Güngör, Mete; Taşcı, Tolga; Bese, Tugan; Turan, Hasan; Kahramanogğu, İlker; Yalçın, İbrahim; Çelik, Çetin; Demirkıran, Fuat; Köse, Faruk; Arvas, Macit; Ayhan, Ali; Vatansever, Doğan; Taşkıran, Çağatay; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 193687; 134190Introduction: This study aimed to evaluate the diagnostic accuracy of the sentinel lymph node (SLN) mapping algorithm in high-risk endometrial cancer patients. Methods: Two hundred forty-four patients with non-endometrioid histology, grade 3 endometrioid tumors and/or tumors with deep myometrial invasion were enrolled in this retrospective, multicentric study. After removal of SLNs, all patients underwent pelvic +/- paraaortic lymphadenectomy. Operations were performed via laparotomy, laparoscopy or robotic surgery. Indocyanine green (ICG) and methylene blue (MB) were used as tracers. SLN detection rate, sensitivity, negative predictive value (NPV) and false-negative rate (FNR) were calculated. Results: Surgeries were performed via laparotomy in 132 (54.1%) patients and 152 (62.3%) underwent both bilateral pelvic and paraaortic lymphadenectomy. At least 1 SLN was detected in 222 (91%) patients. Fifty-five (225%) patients had lymphatic metastasis and 45 patients had at least 1 metastatic SLN. Lymphatic metastases were detected by side-specific lymphadenectomy in 8 patients and 2 patients had isolated paraaortic metastasis. Overall sensitivity, NPV and FNR of SLN biopsy were 81.8%, 95% and 182%, respectively. By applying SLN algorithm steps, sensitivity and NPV improved to 96.4% and 98.9%, respectively. For grade 3 tumors, sensitivity, NPV and FNR of the SLN algorithm were 97.1%, 98.9% and 2.9%. Conclusion: SLN algorithm had high diagnostic accuracy in high-risk endometrial cancer. All pelvic metastases were detected by the SLN algorithm and the isolated paraaortic metastasis rate was ignorable. But long-term survival studies are necessary before this approach becomes standard of care.Publication Metadata only Laparoscopic removal of bladder from the uterine niche with retrograde dissection(Elsevier, 2015) N/A; N/A; Mısırlıoğlu, Selim; Türkgeldi, Engin; Taşkıran, Çağatay; Urman, Cumhur Bülent; Doctor; Faculty Member; Faculty Member; Faculty Member; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; N/A; 329649; 134190; 12147N/APublication Metadata only Impact of endometriomas and their removal on ovarian reserve(Lippincott Williams & Wilkins, 2015) Uncu, Gurkan; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910Purpose of review The effect of endometrioma on ovulatory function and ovarian reserve was unclear. Conflicting opinions exist regarding effect of endometrioma excision on ovarian reserve. Recent findings Endometriomas do not seem to affect ovulatory function. Women with endometrioma have lower antral follicle count and serum anti-Mullerian hormone levels than age-matched healthy controls. There is high-quality evidence suggesting a significant decline in serum anti-Mullerian hormone levels following endometrioma excision. However, a similarly significant decline in antral follicle count is not demonstrated. Cauterization seems to be a contributing factor to ovarian damage and suturing the cyst bed could perhaps be a better alternative. Summary It seems prudent to warn patients regarding loss of ovarian reserve following endometrioma excision. Surgeons should cautiously limit the use of cauterization following stripping of endometrioma. Well designed studies comparing effect of various haemostatic measures on ovarian reserve are needed.Publication Metadata only Progestins vs gonadotropin releasing hormone analogues for pituitary suppression during ovarian stimulation for assisted reproductive technology, a systematic review and meta-analysis(Oxford Univ Press, 2020) Yıldız, Şule; Alexandru, Polexa; Çekiç, Sebile Güler; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; N/A; Doctor; Faculty Member; Faculty Member; Koç University Hospital; School of Medicine; N/A; N/A; School of Medicine; School of Medicine; 134205; N/A; N/A; 329649; 182910N/APublication Metadata only Relations between second-trimester aneuploidy screening results and prediction of labour induction success in term pregnancies(2021) Karakoç, Gökhan; Eroğlu, Hasan; Çakır, Caner; Yavuz, And; Yücel, Aykan; N/A; Turğal, Mert; Doctor; N/A; Koç University Hospital; N/AWe aimed to assess whether the second-trimester maternal serum markers could be used for the prediction of labour induction success. This prospective study enrolled women planned labour induction at term. Women were assigned to one of two groups: vaginal prostaglandin or balloon dilatation. All patients were evaluated for Bishop score, maternal serum oestriol, human chorionic gonadotropin and progesterone at the time of second-aneuploidy screening. The total successful rate for induction of labour was 63.9% in both groups. Maternal serum oestriol multiple of median (MoM) values were significantly lower among the caesarean section group compared to the vaginal delivery group (p < .001). A MoM value of 0.74 for oestriol was associated with a sensitivity of 75.9%, specificity of 41.0%, a positive predictive value of 76.6% and a negative predictive value of 58.0% for a successful induction of labour. Oestriol had a good performance in the prediction of successful induction of labour at term.