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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/6

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Department: search.filters.department.Department of Mechanical EngineeringSubject: search.filters.subject.Medicine

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    PublicationOpen Access
    Post-implantation shear stress assessment: an emerging tool for differentiation of bioresorbable scaffolds
    (Springer, 2019) Tenekecioğlu, Erhan; Torii, Ryo; Katagiri, Yuki; Chichareon, Ply; Asano, Taku; Miyazaki, Yosuke; Takahashi, Kuniaki; Modolo, Rodrigo; Al-Lamee, Rasha; Al-Lamee, Kadem; Colet, Carlos; Reiber, Johan H. C.; van Geuns, Robert; Bourantas, Christos V.; Onuma, Yoshinobu; Serruys, Patrick W.; Department of Mechanical Engineering; Pekkan, Kerem; Faculty Member; Department of Mechanical Engineering; College of Engineering; 161845
    Optical coherence tomography based computational flow dynamic (CFD) modeling provides detailed information about the local flow behavior in stented/scaffolded vessel segments. Our aim is to investigate the in-vivo effect of strut thickness and strut protrusion on endothelial wall shear stress (ESS) distribution in ArterioSorb Absorbable Drug-Eluting Scaffold (ArterioSorb) and Absorb everolimus-eluting Bioresorbable Vascular Scaffold (Absorb) devices that struts with similar morphology (quadratic structure) but different thickness. In three animals, six coronary arteries were treated with ArterioSorb. At different six animals, six coronary arteries were treated with Absorb. Following three-dimensional(3D) reconstruction of the coronary arteries, Newtonian steady flow simulation was performed and the ESS were estimated. Mixed effects models were used to compare ESS distribution in the two devices. There were 4591 struts in the analyzed 477 cross-sections in Absorb (strut thickness=157 mu m) and 3105 struts in 429 cross-sections in ArterioSorb (strut thickness=95 mu m) for the protrusion analysis. In cross-section level analysis, there was significant difference between the scaffolds in the protrusion distances. The protrusion was higher in Absorb (97% of the strut thickness) than in ArterioSorb (88% of the strut thickness). ESS was significantly higher in ArterioSorb (1.52 +/- 0.34Pa) than in Absorb (0.73 +/- 2.19Pa) (p=0.001). Low- and very-low ESS data were seen more often in Absorb than in ArterioSorb. ArterioSorb is associated with a more favorable ESS distribution compared to the Absorb. These differences should be attributed to different strut thickness/strut protrusion that has significant effect on shear stress distribution.
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    PublicationOpen Access
    Role of flow preference in decision making regarding the use of Blalock-Taussig shunt reply
    (Turkish Society of Cardiology, 2018) Arnaz, Ahmet; Department of Mechanical Engineering; Pişkin, Şenol; Researcher; Department of Mechanical Engineering; Graduate School of Sciences and Engineering; 148702
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    PublicationOpen Access
    Mitochondrial donation in translational medicine; from imagination to reality
    (BioMed Central, 2020) Bani, Farhad; Zarebkohan, Amir; Rahbarghazi, Reza; Department of Mechanical Engineering; Taşoğlu, Savaş; Sokullu, Emel; Faculty Member; Faculty Member; Department of Mechanical Engineering; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; School of Medicine; N/A; 291971; 163024
    The existence of active crosstalk between cells in a paracrine and juxtacrine manner dictates specific activity under physiological and pathological conditions. Upon juxtacrine interaction between the cells, various types of signaling molecules and organelles are regularly transmitted in response to changes in the microenvironment. To date, it has been well-established that numerous parallel cellular mechanisms participate in the mitochondrial transfer to modulate metabolic needs in the target cells. Since the conception of stem cells activity in the restoration of tissues' function, it has been elucidated that these cells possess a unique capacity to deliver the mitochondrial package to the juxtaposed cells. The existence of mitochondrial donation potentiates the capacity of modulation in the distinct cells to achieve better therapeutic effects. This review article aims to scrutinize the current knowledge regarding the stem cell's mitochondrial transfer capacity and their regenerative potential.