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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/6
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Publication Open Access Surveying the adaptations during the COVID-19 outbreak in Turkish radiotherapy practice(Kare Yayıncılık, 2021) Topkan, Erkan; Sezen, Duygu; Selek, Uğur; Akdemir, Eyüb Yaşar; Şenyürek, Şükran; Durankuş, Nilüfer Kılıç; Bölükbaşı, Yasemin; Faculty Member; Faculty Member; Doctor; Faculty Member; School of Medicine; Koç University Hospital; 170535; 27211; N/A; N/A; N/A; 216814Objective: we aimed to assess how Turkish Radiation Oncology departments responded to the COVID-19 out-break and to what extent adapted their routine practice per recent guidelines and recommendations. Methods: in late March 2020, a national survey was designed for Turkish radiation oncologists who were actively practicing and members of the Turkish Society for Radiation Oncology (TSRO). The survey created with an online survey program (www.SurveyMonkey.com), including 28 focused items. It was sent to all members of the TSRO on April 4th 2020. Results: of responders, 17% noted to already complete these arrangements even before the first case announced. All of the responders declared that their team members, including the secretaries, nurses, and radiation therapists in the clinic, worked with appropriate protective equipment. While one-third of the centers (35%) stated to implement a weekly shift, the other 1/3 (29%) chose to use daily shifts for social distancing and decreasing staff contact. Sixty-two percent of all responders indicated that multidisciplinary tumor boards discontinued, and the remaining 38% stated to continue with online video conferencing programs (65%) or meeting in large rooms with a limited number of attendees social distancing (35%). Conclusion: our survey revealed the importance of early precautions, communication by other Radiation Oncology Departments, following published guidelines during the COVID-19 pandemic, and the importance of using web-based applications for multidisciplinary tumor boards.Publication Open Access Increased levels of anxiety, depression, and secondary trauma in radiation oncologists during COVID-19 pandemic: a preliminary report from Turkey(Kare Yayıncılık, 2021) Albayrak, Yakup; Potas, Nihan; Topkan, Erkan; Durankuş, Nilüfer Kılıç; Bölükbaşı, Yasemin; Sezen, Duygu; Akdemir, Eyüb Yaşar; Şenyürek, Şükran; Selek, Uğur; Faculty Member; Faculty Member; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; 216814; 170535; N/A; N/A; 27211Objective:we surveyed the anxiety, depression, and secondary trauma levels of Turkish Radiation Oncologists related with COVID pandemics. Methods: an anonymous online questionnaire survey was created to evaluate levels of depression, anxiety, and secondary trauma among Turkish Radiation Oncologists. The survey included demographics and occupational status, Secondary Traumatic Stress Scale (STSSS), The Beck Depression Inventory (BDI), The Beck Anxiety Inventory (BAI), and State-Trait Anxiety Inventory (STAI). Results: seventy-two respondents provided the power of about 91.4% for the significance level of 0.05. The variance homogeneity was checked by the Levene test, the effect of COVID-19 on psychology is higher in the group of >19 (9.02 +/- 0.820), as well as the effect of social isolation (8.02 +/- 1.622), the STSS scores (34.28 +/- 9.062), the STAIS scores (60.46 +/- 5.296), the STAIT scores (82.21 +/- 9.298), the BDI scores (22.68 +/- 2.788), and the BAI scores (21.04 +/- 9.321). The multiple regressions to estimate BDI revealed statistically significant effects in STAIS, BAI, and STAIT. There is a significant correlation between STSS, STAIS, STAIT, BDI, BAI, the effect of COVID-19 on psychology, and the effect of social isolation. Conclusion: we have established one of the first studies demonstrating the effects of COVID-19 pandemic on depression, anxiety levels, and secondary trauma on a special physician population, the Radiation Oncologists, who specifically do not directly take part in COVID19 management.Publication Open Access The clinical impact of the late imaging with 18F-fluorodeoxyglucose PET texture analysis in invasive lobular breast cancer(Kare Yayıncılık, 2021) Falay, Fikri Okan; Seymen, Hülya; Teaching Faculty; Teaching Faculty; School of Medicine; 246484; 350778Objective: breast invasive lobular cancer (ILC) is one of the most difficult malignancies to diagnose and follow-up due to its tumor morphology. Tumor heterogeneity is the most important reason for treatment failure and diagnostic limitation. Identification of heterogeneity by a non-invasive method, texture analysis that can be done from positron emission tomography (PET), MR, and CT is developed. In ILC, diagnostic sensitivity is lower with 18F-fluorodeoxyglucose ([18F] FDG) PET/CT compared to invasive ductal carcinoma (IDC). In this study, the correlation between histopathological variables and the texture analysis of [18F] FDG PET/CT standard images, and also late images whose contribution to the diagnosis of many malignancies has been investigated are researched. Methods: twenty ILC patients underwent standard and late [18F] FDG PET/CT imaging for staging between May 2007 and December 2018. T and N stages, histological and nuclear grades, estrogen receptor, progesterone receptor, human epidermal growth factor-2, and Ki-67 were recorded. Results: thirty-two textural indices with conventional and formal indices and histogram values were calculated with LIFEx software to find heterogeneity in standard and late [18F] FDG PET/CT images. Conventional and discrete indices based on GLRM and GLZM are more correlated than other texture indices. Greater number of significantly correlations was found between histopathological variables and texture analysis of late imaging (p<0.05). Conclusion: in our study, the conventional indices, especially in the 2nd degree indices, in the texture analysis performed with [18F] FDG PET/CT significantly correlated in the ILC, which has lower [18F] FDG affinity compared to IDC due to the tumoral tissue characteristics. Although the presence of more correlations with histopathological prognostic information in late images suggests a greater diagnostic contribution, further studies with more numbers are needed.