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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/6
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Publication Open Access Egypt’s manufacturing sector: seizing on an advantageous product space position(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Egypt’s industrial sector is the third in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Egypt’s product space reveals the country should develop the machinery and chemicals & allied industry since they would increase the country’s product complexity index. To meet this specific goal and to enhance production in other sectors, Egypt should focus on providing support and public inputs—such as infrastructure and regulation—to existing industries with the aim of improving their productivity and ability to jump to nearby opportunities.Publication Open Access The EU-Turkey cooperation on migration(2017) Department of International Relations; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 238439Publication Open Access Tunisia’s manufacturing sector: machinery, electronics, and chemical sector potential(2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Tunisia’s industrial sector is the tenth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Tunisia’s product space reveals that the country should focus on facilitating the development of new complex products, particularly in the machinery/electrical clusters and a few products in the chemical and plastic rubber communities that are most attractive in terms of the tradeoff between distance and complexity. These findings call for what is termed parsimonious industrial policy or industrial policy ‘in the small’, entailing providing support and public inputs (such as infrastructure, regulation, etc.) to existing industries with the aim of improving their productivity and ability to jump to the nearby opportunities.Publication Open Access Türkiye Cumhuriyeti Anayasası’nda değişiklik yapılmasına dair kanun (üzerine teknik-bilimsel rapor)(Anayasa_Der (Anayasa Hukuku Araştırmaları Derneği), 2017) Özenç, Berke; Yılmaz, Didem; Kalaycıoğlu, Ersin; Sağlam, Fazıl; Kaboğlu, İbrahim Ö.; Uygun, Oktay; Erözden, Ozan; İnceoğlu, Sibel; Üzeltürk-Tahmazoğlu Sultan; Şirin, Tolga; Özyavuz, Tuncer; Emre,Yunus; Taşkın, Yüksel; Berksoy, İrem; N/A; Department of International Relations; Oder, Bertil Emrah; Somer, Murat; Faculty Member; Faculty Member; Department of International Relations; Law School; College of Administrative Sciences and Economics; 4038; 110135Publication Open Access Bi-allelic loss-of-function variants in TMEM147 cause moderate to profound intellectual disability with facial dysmorphism and pseudo-Pelger-Huet anomaly(Elsevier, 2022) Thomas, Quentin; Motta, Marialetizia; Gautier, Thierry; Zaki, Maha S.; Ciolfi, Andrea; Paccaud, Julien; Girodon, Francois; Boespflug-Tanguy, Odile; Besnard, Thomas; Kerkhof, Jennifer; McConkey, Haley; Masson, Aymeric; Denomme-Pichon, Anne-Sophie; Cogne, Benjamin; Trochu, Eva; Vignard, Virginie; El It, Fatima; Rodan, Lance H.; Alkhateeb, Mohammad Ayman; Abou Jamra, Rami; Duplomb, Laurence; Tisserant, Emilie; Duffourd, Yannis; Bruel, Ange-Line; Jackson, Adam; Banka, Siddharth; McEntagart, Meriel; Saggar, Anand; Gleeson, Joseph G.; Sievert, David; Bae, Hyunwoo; Lee, Beom Hee; Kwon, Kisang; Seo, Go Hun; Lee, Hane; Saeed, Anjum; Anjum, Nadeem; Cheema, Huma; Alawbathani, Salem; Khan, Imran; Pinto-Basto, Jorge; Teoh, Joyce; Wong, Jasmine; Sahari, Umar Bin Mohamad; Houlden, Henry; Zhelcheska, Kristina; Pannetier, Melanie; Awad, Mona A.; Lesieur-Sebellin, Marion; Barcia, Giulia; Amiel, Jeanne; Delanne, Julian; Philippe, Christophe; Faivre, Laurence; Odent, Sylvie; Bertoli-Avella, Aida; Thauvin, Christel; Sadikovic, Bekim; Maroofian, Reza; Govin, Jerome; Tartaglia, Marco; Vitobello, Antonio; Reversade, Bruno; Faculty Member; School of MedicineThe transmembrane protein TMEM147 has a dual function: first at the nuclear envelope, where it anchors lamin B receptor (LBR) to the inner membrane, and second at the endoplasmic reticulum (ER), where it facilitates the translation of nascent polypeptides within the ribosome-bound TMCO1 translocon complex. Through international data sharing, we identified 23 individuals from 15 unrelated families with bi-allelic TMEM147 loss-of-function variants, including splice-site, nonsense, frameshift, and missense variants. These affected children displayed congruent clinical features including coarse facies, developmental delay, intellectual disability, and behavioral problems. In silico structural analyses predicted disruptive consequences of the identified amino acid substitutions on translocon complex assembly and/or function, and in vitro analyses documented accelerated protein degradation via the autophagy-lysosomal-mediated pathway. Furthermore, TMEM147-deficient cells showed CKAP4 (CLIMP-63) and RTN4 (NOGO) upregulation with a concomitant reorientation of the ER, which was also witnessed in primary fibroblast cell culture. LBR mislocalization and nuclear segmentation was observed in primary fibroblast cells. Abnormal nuclear segmentation and chromatin compaction were also observed in approximately 20% of neutrophils, indicating the presence of a pseudo-Pelger-Huet anomaly. Finally, co-expression analysis revealed significant correlation with neurodevelopmental genes in the brain, further supporting a role of TMEM147 in neurodevelopment. Our findings provide clinical, genetic, and functional evidence that bi-allelic loss-of-function variants in TMEM147 cause syndromic intellectual disability due to ER-translocon and nuclear organization dysfunction.Publication Open Access UAE’s manufacturing sector: small industry, significant potential(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on the United Arab Emirates’ (UAE) industrial sector is the sixth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of the UAE’s product space reveals the country’s future path for development should focus on new opportunities in the chemical and foodstuff clusters. This reports calls for what is termed parsimonious industrial policy or industrial policy ‘in the small’, entailing a focus on providing support and public inputs (such as infrastructure, regulation, etc.) to existing industries with the aim of improving their productivity and ability to jump to nearby opportunities.Publication Open Access Energy and climate strategies, interests, and priorities of EU and Turkey(FEUTURE: The Future of EU-Turkey Relations, 2017) Colantoni, Lorenzo; Korkmaz, Dicle; Sartori, Nicolò; Schroeder, Mirja; Sever-Mehmetoğlu, Duygu; Department of International Relations; Yılmaz, Şuhnaz Özbağcı; Faculty Member; Department of International Relations; College of Administrative Sciences and Economics; 46805Energy is one of the sectors in which EU–Turkey cooperation could be most fruitful, possibly leading overall convergence through the common achievement of mutual interests in key areas – in particular, natural gas imports and diversification. Yet, this collaboration is undermined by the uncertainty over Turkey’s position vis-à-vis these policies and its undefined commitment to others, such as renewables and nuclear power; by doubts over the ability of the EU to balance security of supply, sustainability and competitiveness; and by the unclear growth trends of both regions. This situation is partially balanced by Turkey’s and the EU’s participation in several – sometimes successful – platforms for energy cooperation on the bilateral and multilateral levels (i.e. ENTSO-E, the European Network of Transmission System Operators for Electricity and MedTSO, the Association of the Mediterranean Transmission System Operators), which are aimed at the integration of the two polities’ energy markets. Nonetheless, the overall energy framework still needs a strong policy boost to set it on a common path towards convergence.Publication Open Access Arab country product space report introduction and methodology(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280During the decades prior to the Arab spring, Arab countries on average had one of the lowest per capita growth rates compared to other parts of the world. Although countries in the region registered higher growth rates at the beginning of the century, this economic growth did not bring about a structural transformation required to diversify Arab economies. The challenge remains not only in how to ensure these economies grow but also to ensure that growth is inclusive and sustainable. The general objective of the report is to lay out the strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, the existing capabilities of selected economies are analyzed by locating products they currently export, which assists in determining which path they should follow to produce more sophisticated and strategic products.Publication Open Access Saudi Arabia’s manufacturing sector: looking beyond petroleum(The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Saudi Arabia’s industrial sector is the fourth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Saudi Arabia’s product space reveals that the kingdom’s development path should focus on new complex products in the machinery/electrical clusters and a few products in the chemical community. In Saudi Arabia, enhancing production possibilities around existing industries will likely not produce leaps that are desired, meaning it will likely be necessary to place strategic bets or adopt industrial policy ‘in the large’ to ease the transition into new and more complex industries.Publication Open Access Iraq’s manufacturing sector: a challenging path to more products(The Lebanese Center for Policy Studies (LCPS), 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280This policy report on Iraq’s industrial sector is the seventh in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. A study of Iraq’s product space reveals that given its limited diversification and strong dependence on oil, the country’s future path for development should focus on new opportunities in the foodstuff and chemical clusters. To meet this goal, industrial policy should focus on selecting a number of new industries or products at which to target public inputs in order to provide temporary public support that will attract and facilitate private investment in new products.