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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/6
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Publication Open Access Effects of preeclampsia on the amplitude integrated electroencephalography activity in preterm infants(De Gruyter, 2016) Topçuoğlu, Sevilay; Kolsuz, Leyla Daban; Ovalı, Fahri; Karatekin, Güner; N/A; Gürsoy, Tuğba; Faculty Member; School of Medicine; 214691Objective: Preeclampsia leads to chronic intrauterine hypoxia by interfering with placental blood supply. The aim of this study was to investigate whether preeclampsia exposure has an influence on the central nervous system of infants, as monitored by amplitude integrated electro-encephalography (aEEG).Publication Open Access The survivorship bias in congenital diaphragmatic hernia(Multidisciplinary Digital Publishing Institute (MDPI), 2022) Aydın, Emrah; Haberman, Beth; Lim, Foong-Yen; Peiro, Jose L.; Torlak, Nilhan; Graduate School of Health SciencesCurrent literature for congenital diaphragmatic hernia (CDH) focuses on the comparison of the overall mortality in CDH patients. Only a few studies concentrate on analyzing the unstable patients who could not achieve surgical repair, as well as those who could but did not survive after. Hence, this study aimed to analyze the effects of various parameters on the timing of death. A retrospective analysis was performed by using the data of all CDH patients from 2003 to 2016 at a single tertiary center. Patients who were diagnosed with left-sided CDH and expired were included in the study regardless of the cause. Of the 66 expired patients, 5 were excluded due to right-sided CDH. The study population constituted a total of 61 patients, of which 31 patients expired prior to CDH repair, and 30 patients expired at different times after CDH repair. Multinomial regression analysis identified that the ECMO need (B = 20.257, p = 0.000, OR: 62.756, 95% CI 10.600-371.384) and O/E LHR (B = 20.376, p = 0.000, OR: 70.663, 95% CI 48.716-102.415) values were the independent predictors that influenced mortality in this cohort. Prenatal pulmonary measurements are the major predictors determining the severity of the disease in patients with CDH.Publication Open Access Maturity onset diabetes of the young due to Glucokinase, HNF1-A, HNF1-B, and HNF4-A mutations in a cohort of Turkish children diagnosed as type 1 diabetes mellitus(Karger Publishers, 2019) Özsu, Elif; Çizmecioğlu, Filiz Mine; Yüksel, Ayşegül Büte; Çalışkan, Mürsel; Yeşilyurt, Ahmet; N/A; Yeşiltepe Mutlu, Rahime Gül; Hatun, Şükrü; Faculty Member; School of Medicine; N/A; 153504Background/aims: maturity onset diabetes of the young (MODY) is a rare condition often misdiagnosed as type 1 diabetes (T1D). The purposes of this study were: to identify any patients followed in a large Turkish cohort as T1D, with an atypical natural history, who may in fact have MODY, and to define the criteria which would indicate patients with likely MODY as early as possible after presentation to allow prompt genetic testing. Methods: Urinary C-peptide/creatinine ratio (UCPCR) was studied in 152 patients having a diagnosis of T1D for at least 3 years. Those with a UCPCR ≥0.2 nmol/mmol were selected for genetic analysis of the Glucokinase (GCK), Hepatocyte nuclear factor 1a (HNF1A), Hepatocyte nuclear factor 4a (HNF4A), and Hepatocyte nuclear factor 1b (HNF1B) genes. This UCPCR cut-off was used because of the reported high sensitivity and specificity. Cases were also evaluated using a MODY probability calculator. Results: twenty-three patients from 152 participants (15.1%) had a UCPCR indicating persistent insulin reserve. The mean age ± SD of the patients was 13.6 ± 3.6 years (range 8.30-21.6). Of these 23, two (8.7%) were found to have a mutation, one with HNF4A and one with HNF1B mutation. No mutations were detected in the GCK or HNF1A genes. Conclusion: in Turkish children with a diagnosis of T1D but who have persistent insulin reserve 3 years after diagnosis, up to 9% may have a genetic mutation indicating a diagnosis of MODY.Publication Open Access Editorial: novel horizons in pediatric food allergy(Frontiers, 2022) Barni, S.; Büyüktiryaki, Ayşe Betül; Faculty Member; School of Medicine; 195944NAPublication Open Access Allergen immunotherapy for IgE-mediated food allergy: protocol for a systematic review(BioMed Central, 2016) Dhami, S.; Nurmatov, U.; Pajno, G. B.; Fernandez-Rivas, M.; Muraro, A.; Roberts, G.; Akdiş, C.; Alvaro-Lozano, M.; Beyer, K.; Bindslev-Jensen, C.; Burks, W.; du Toit, G.; Ebisawa, M.; Eigenmann, P.; Knol, E.; Makela, M.; Nadeau, K. C.; O'Mahony, L.; Papadopoulos, N.; Poulsen, L.; Sampson, H.; Santos, A.; van Ree, R.; Timmermans, F.; Sheikh, A.; N/A; Saçkesen, Cansın; Faculty Member; School of Medicine; 182537Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing the EAACI Guidelines for Allergen Immunotherapy (AIT) for IgE-mediated food allergy. We seek to critically assess the effectiveness, cost-effectiveness and safety of AIT in IgE-mediated food allergy. Methods: We will undertake a systematic review, which will involve searching international biomedical databases for published, in progress and unpublished evidence. Studies will be independently screened against pre-defined eligibility criteria and critically appraised using established instruments. Data will be descriptively and, if possible and appropriate, quantitatively synthesised. Discussion: The findings from this review will be used to inform the development of recommendations for EAACI's Guidelines on AIT.Publication Open Access Current trends in tolerance induction in cow's milk allergy: from passive to proactive strategies(Frontiers, 2019) Altıntaş, Derya Ufuk; Bingol, Ayşen; Bingol, Gülbin; Büyüktiryaki, Betül; Demir, Esen; Kansu, Aydan; Kuloğlu, Zarife; Tamay, Zeynep; Sekerel, Bülent Enis; N/A; Saçkesen, Cansın; Faculty Member; School of Medicine; 182537This review addresses the current strategies of inducing tolerance development in infant and childhood cow's milk protein allergy (CMPA). The change in prevention strategies for CMPA has been emphasized based on the lack of evidence to support the efficacy of food allergen avoidance in infancy and the concept of the dual-allergen-exposure hypothesis, which suggests that allergen exposure through the skin leads to sensitization, whereas early oral consumption of allergenic food protein induces oral tolerance. The new approach is based on the likelihood of early introduction of allergenic foods to the infant's diet to reduce the development of food allergies through oral tolerance induction. The latest treatment guidelines recommend the continuation of breast feeding and the elimination of cow's milk and products from the maternal diet in exclusively breast-fed infants with CMPA, the use of an extensively hydrolyzed infant formula (eHF) with proven efficacy in CMPA as the first elimination diet in formula-fed infants with CMPA and the use of amino acid-based formula (AAF) in severe cases, such as anaphylaxis, enteropathy, eosinophilic esophagitis, and food protein-induced enterocolitis syndrome (FPIES), as well as cases of multiple system involvement, multiple food allergies, and intolerance to extensively hydrolyzed formula (eHF). In conclusion, this paper presents the current knowledge on tolerance development in infants and children with CMPA to increase the awareness of the clinicians concerning the new approaches in CMPA treatment Tolerance development is considered a relatively new concept in CMPA, inducing a shift in interventions in CMPA from a passive (avoidance of responsible allergen) toward a proactive (tolerance induction) strategy.Publication Open Access Symptomatology and clinic of hydronephrosis associated with uretero pelvic junction anomalies(Frontiers, 2020) Bilge, İlmay; Faculty Member; School of Medicine; 198907The most common cause of hydronephrosis in the pediatric age group is ureteropelvic junction-type hydronephrosis (UPJHN). Since the advent of widespread maternal ultrasound screening, clinical presentation of hydronephrosis associated with UPJ anomalies has changed dramatically. Today most cases are diagnosed in the prenatal period, and neonates present without signs or symptoms. For those who are not detected at birth, UPJHN eventually presents throughout childhood and even adulthood with various symptoms. Clinical picture of UPJHN highly depends on the presence and severity of obstruction, and whether it affects single or both kidneys. Abdominal or flank pain, abdominal mass, hematuria, kidney stones, urinary tract infections (UTI), and gastrointestinal discomfort are the main symptoms of UPJHN in childhood. Other less common findings in such patients are growth retardation, anemia, and hypertension. UTI is a relatively rare condition in UPJHN cases, but it may occur as pyelonephritis. Vesicoureteric reflux should be kept in mind as a concomitant pathology in pediatric UPJHN that develop febrile UTI. Although many UPJHN cases are known to improve over time, close clinical observation is critical in order to avoid irreversible kidney damage. The most appropriate approach is to follow-up the patients considering the presence of symptoms, the severity of hydronephrosis and the decrease in kidney function and, if necessary, to decide on early surgical intervention.Publication Open Access Epidemiological, clinical, and laboratory features of children with COVID-19 in Turkey(Frontiers, 2021) Karbuz, Adem; Akkoç, Gülşen; Bedir Demirdağ, Tuğba; Yılmaz Çiftdoğan, Dilek; Özer, Arife; Çakır, Deniz; Hançerli Törün, Selda; Kepenekli, Eda; Erat, Tuğba; Dalgıç, Nazan; İlbay, Sare; Karaaslan, Ayşe; Erdeniz, Emine H.; Aygün, F. Deniz; Bozdemir, S. Elmas; Hatipoğlu, Nevin; Emiroğlu, Melike; Şahbudak Bal, Zümrüt; Çiftçi, Ergin; Bayhan, Gülsüm İclal; Gayretli Aydın, Zeynep Gökçe; Öcal Demir, Sevliya; Kılıç, Ömer; Hacımustafaoğlu, Mustafa; Şener Okur, Dicle; Şen, Semra; Yahşi, Aysun; Çetin, Benhur; Sütçü, Murat; Kara, Manolya; Uygun, Hatice; Tural Kara, Tuğçe; Korukluoğlu, Gülay; Akgün, Özlem; Üstündağ, Gülnihan; Demir Mis, Mevsim; Salı, Enes; Kaba, Özge; Yakut, Nurhayat; Kılıç, Orhan; Kanık, M. Kemal; Çetin, Ceren; Dursun, Adem; Çiçek, Muharrem; Koçkuzu, Esra; Şevketoğlu, Esra; Alkan, Gülsüm; Güner Özenen, Gizem; İnce, Erdal; Baydar, Zekiye; Özkaya, Ahmet Kağan; Ovalı, Hüsnü Fahri; Tekeli, Seher; Çelebi, Solmaz; Çubukçu, Birgül; Bal, Alkan; Köse, Mehmet; Hatipoğlu, Halil Uğur; Dalkıran, Tahir; Turgut, Mehmet; Başak Altaş, Ayşe; Selçuk Duru, Hatice Nilgün; Aksay, Ahu; Sağlam, Sevcan; Sarı Yanartaş, Mehpare; Ergenç, Zeynep; Akın, Yasemin; Düzenli Kar, Yeter; Şahin, Sabit; Tüter Öz, Şadiye Kübra; Bilen, Nimet Melis; Özdemir, Halil; Şenoglu, Mine Çiğdem; Parıltan Küçükalioğlu, Burcu; Besli, Gülser Esen; Kara, Yalçın; Turan, Cansu; Selbest Demirtaş, Burcu; Coşgun, Yasemin; Elevli, Murat; Şahin, Aslıhan; Bahtiyar Oğuz, Şerife; Somer, Ayper; Karadağ, Bülent; Demirhan, Recep; Türk Dağı, Hatice; Kurugöl, Zafer; Taşkın, Esra Çakmak; Şahiner, Ayşegül; Yeşil, Edanur; Ekemen Keleş, Yıldız; Sarıkaya, Remzi; Erdem Eralp, Ela; Özkınay, Ferda; Konca, Hatice Kübra; Yılmaz, Songül; Gökdemir, Yasemin; Arga, Gül; Özen, Seval; Çoksüer, Fevziye; Vatansever, Göksel; Tezer, Hasan; Kara, Ateş; Aktürk, Hacer; Khalilova, Fidan; Çelikyurt, Aydın; Faculty Member; Doctor; School of Medicine; Koç University HospitalObjectives: the aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children.Methods: a retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: there were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% (n = 582) and females constituted 49.7% (n = 574). The median age of the confirmed cases was 10.75 years (4.5-14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1-3 years of age (9.3%), 148 were 3-6 years of age (12.8%), 298 were 6-12 years of age (25.8%), 233 were 12-15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) (n = 583) for a median of 2 days (IQR: 1-3 days). Fever was median at 38.4 degrees C (38.0-38.7 degrees C). The second most common symptom was cough (n = 543, 46.9%). The other common symptoms were sore throat (n = 143, 12.4%), myalgia (n = 141, 12.2%), dyspnea (n = 118, 10.2%), diarrhea (n = 112, 9.7%), stomachache (n = 71, 6.1%), and nasal discharge (n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition (p < 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have (p = 0.38), but the need for intensive care was higher in patients who had an underlying condition (p < 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: to the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution.