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Item Metadata only “Princeton’s gift to Turkey”: exploring the political matrix of the Orpheus mosaic from Jerusalem and Late Ottoman Sardis(Penn State University Press, 2023) 0000-0003-0979-2510; L Çelik, Semih; Department of Archeology and History of Art; Roosevelt, Christina Marie Luke; Faculty Member; College of Social Sciences and Humanities; 235112Whereas it has often been argued that conflict and Western imperial ambitions and ensuing Ottoman defensive policies guided the direction of late nineteenth-and early twentieth-century archaeology in Anatolia and the Middle East, here we offer a perspective of high-profile American-Ottoman mutual partage diplomacy. This view stems from the relationship between Princeton University and the Imperial Museum in Constantinople. From a multiscalar approach that includes microlocal and macroimperial histories, we demonstrate how this American alliance trumped Ottoman citizenship and transcended physical and political jurisdictions. “Princeton’s Gift to Turkey”—the excavation, transfer, and installment of the Orpheus mosaic from the northwest corner of the Damascus Gate in Jerusalem to the Imperial Museum—triggered a lasting relationship between Osman Hamdi Bey and Howard Crosby Butler. Underwritten by financial means and technological capacity, this alliance foreshadowed the transformative period at Late Ottoman Sardis. © 2023 The Pennsylvania State University, University Park, PA.Publication Open Access #COVID19 and #Breastcancer: a qualitative analysis of tweets(Multidisciplinary Digital Publishing Institute (MDPI), 2022) Naganathan, G.; Cleland, J.; Reel, E.; Cil, T.; Bilgen, İdil; School of MedicineRapid and efficient communication regarding quickly evolving medical information was paramount for healthcare providers and patients throughout the COVID-19 pandemic. Over the last several years, social media platforms such as Twitter have emerged as important tools for health promotion, virtual learning among healthcare providers, and patient support. We conducted a qualitative thematic content analysis on tweets using the hashtags #BreastSurgery, #BreastCancer, #BreastOncology, #Pandemic, and #COVID19. Advocacy organizations were the most frequent authors of tweets captured in this dataset, and most tweets came from the United States of America (64%). Seventy-three codes were generated from the data, and, through iterative, inductive analysis, three major themes were developed: patient hesitancy and vulnerability, increased efforts in knowledge sharing, and evolving best practices. We found that Twitter was an effective way to share evolving best practices, education, and collective experiences among key stakeholders. As Twitter is increasingly used as a tool for health promotion and knowledge translation, a better understanding of how key stakeholders engage with healthcare-related topics on the platform can help optimize the use of this powerful tool.Publication Metadata only 1200 nm pumped Tm3+:Lu2O3 ceramic lasers(Optical Soc Amer, 2018) Özharar, Sarper; N/A; Department of Physics; Department of Physics; Toker, Işınsu Baylam; Sennaroğlu, Alphan; PhD Student; Faculty Member; N/A; College of Sciences; N/A; 23851We report on an experimental demonstration of a 1200-nm pumped Tm3+:Lu2O3 ceramic laser. By using a gain-switched, tunable Cr4+:forsterite laser, the excitation spectrum was measured, with optimum pumping bands centered near 1198 nm, 1204 nm, and 1211 nm. The highest slope efficiency of 21.5% was obtained at the pump wavelength of 1204 nm. Comparative energy efficiency measurements performed near 1200-nm and 800-nm pumping further showed that nearly 40% improvement was obtained in slope efficiency measured with respect to the incident pump energy for 1200-nm pumping. A transition was further observed from single-wavelength operation at 2066 nm to dual-wavelength operation near 2066 nm and 1967 nm for absorbed pump energies above 50 mu J. In this regime, two consecutive output pulses were observed in the time domain. The shortest temporal duration of the first pulse was 1.1 mu s at the incident pulse energy of 105 mu J. The duration and build-up time of the second pulse remained around 5.9 mu s and 18.5 mu s. We believe that the improved energy efficiency demonstrated for the 1.5% Tm3+:Lu2O3 ceramic with 1200-nm pumping can be used as an alternative scheme for the excitation of Tm3+:Lu2O3 ceramic lasers.Publication Metadata only [Our] age of anxiety: existentialism and the current state of international relations(Palgrave Macmillan Ltd, 2021) Department of International Relations; Department of International Relations; Rumelili, Bahar; Faculty Member; College of Administrative Sciences and Economics; 51356This article is based on the keynote address I delivered in June 2019 at the Central and Eastern European international Studies association (CEEISa) conference in Belgrade. Drawing on existentialist thought, I first discuss the distinction between anxiety and fear and the relevance of this distinction for International relation (IR) theory. then, building on the Heideggerian notion of mood and its recent applications to IR by Erik Ringmar (2017, 2018), I argue that anxiety impacts International relation as a public mood-'a collective way of being attuned to the world'. Connecting existentialist thought on anxiety with contemporary IR and Political science research on securitisation and populism, I discuss how, in periods and contexts where we are collectively attuned to the world in anxiety, the resonance of securitisation and the appeal of nativist and populist doctrines that offer ideological and moral certainty are enhanced.Publication Metadata only A biallelic ANTXR1 variant expands the anthrax toxin receptor associated phenotype to tooth agenesis(Wiley, 2018) Dinckan, Nuriye; Du, Renqian; Akdemir, Zeynep C.; Bayram, Yavuz; Jhangiani, Shalini N.; Doddapaneni, Harsha; Hu, Jianhong; Muzny, Donna M.; Guven, Yeliz; Aktoren, Oya; Boerwinkle, Eric; Gibbs, Richard A.; Posey, Jennifer E.; Lupski, James R.; Uyguner, Zehra O.; Letra, Ariadne; N/A; Kayserili, Hülya; Faculty Member; School of Medicine; 7945Tooth development is regulated by multiple genetic pathways, which ultimately drive the complex interactions between the oral epithelium and mesenchyme. Disruptions at any time point during this process may lead to failure of tooth development, also known as tooth agenesis (TA). TA is a common craniofacial abnormality in humans and represents the failure to develop one or more permanent teeth. Many genes and potentially subtle variants in these genes contribute to the TA phenotype. We report the clinical and genetic impact of a rare homozygous ANTXR1 variant (c.1312C>T), identified by whole exome sequencing (WES), in a consanguineous Turkish family with TA. Mutations in ANTXR1 have been associated with GAPO (growth retardation, alopecia, pseudoanodontia, and optic atrophy) syndrome and infantile hemangioma, however no clinical characteristics associated with these conditions were observed in our study family. We detected the expression of Antxr1 in oral and dental tissues of developing mouse embryos, further supporting a role for this gene in tooth development. Our findings implicate ANTXR1 as a candidate gene for isolated TA, suggest the involvement of specific hypomorphic alleles, and expand the previously known ANTXR1-associated phenotypes.Item Metadata only A Brief atlas of insulin(Bentham Science Publishers, 2023) N/A; 0000-0002-9135-5397; N/A; Department of Molecular Biology and Genetics; Ayan, Esra; Demirci, Hasan; PhD Student; Faculty Member; Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID); Graduate School of Sciences and Engineering; College of Sciences; N/A; 307350Insulin is an essential factor for mammalian organisms: a regulator of glucose metabolism and other key signaling pathways. Insulin is also a multifunctional hormone whose absence can cause many diseases. Recombinant insulin is widely used in the treatment of diabetes. Understanding insulin, biosimilars, and biobetters from a holistic perspective will help pharmacologically user-friendly molecules design and develop personalized medicine-oriented therapeutic strategies for diabetes. Additionally, it helps to understand the underlying mechanism of other insulin-dependent metabolic disorders. The purpose of this atlas is to review insulin from a biotechnological, basic science, and clinical perspective, explain nearly all insulin-related disorders and their underlying molecular mechanisms, explore exogenous/recombinant production strategies of patented and research-level insulin/analogs, and highlight their mechanism of action from a structural perspective. Combined with computational analysis, comparisons of insulin and analogs also provide novel information about the structural dynamics of insulin.Publication Open Access A case of Burkitt’s lymphoma mimicking peritonitis carcinomatosa(Galenos Yayınevi, 2020) Örnek, Serdar; Tecimer Tülay; Ferhanoğlu, Ahmet Burhan; Büyüktaş, Deram; Faculty Member; Faculty Member; School of Medicine; 18320; N/APublication Metadata only A case of drop foot due to piriformis syndrome(Springer Heidelberg, 2015) Yıldırım, Pelin; Güler, Tuba; Özer, Tülay; Gündüz, Osman Hakan; N/A; Mısırlıoğlu, Tuğçe Özekli; Doctor; N/A; Koç University Hospital; 175999N/APublication Metadata only A case of secondary hemophagocytic lymphohistiocytosis (HLH) following incomplete kawasaki's disease (KD). Importance of distinguishing recurrent kd from HLH(2014) Kebudi, R.; Dindar, A.; Gürakan, F.; Devecioğlu, O.; Sözmen, Banu Oflaz; Faculty Member; School of Medicine; 198711N/AItem Metadata only A characterization of quasipositive two-bridge knots(World Scientific Publ Co Pte Ltd, 2024) 0000-0002-9758-1045; Orevkov, Stepan; Department of Mathematics; Özbağcı, Burak; Faculty Member; College of Sciences; 29746We prove a simple necessary and sufficient condition for a two-bridge knot K(p,q) to be quasipositive, based on the continued fraction expansion of p/q. As an application, coupled with some classification results in contact and symplectic topology, we give a new proof of the fact that smoothly slice two-bridge knots are non-quasipositive. Another proof of this fact using methods within the scope of knot theory is presented in Appendix A, by Stepan Orevkov.