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Publication Metadata only Editorial expression of concern: generation of TRAIL-resistant cell line models reveals distinct adaptive mechanisms for acquired resistance and re-sensitization(Springer Nature, 2024) Esai Selvan, Myvizhi; Bhere, Deepak; Shah, Khalid.; Cingöz, Ahmet; Özyerli, Ezgi; Gümüş, Zeynep Hülya; Solaroğlu, İhsan; Önder, Tuğba Bağcı; Morova, Tunç; Şeker-Polat, Fidan; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); Graduate School of Health Sciences; Graduate School of Sciences and Engineering; School of Medicine;Editorial Expression of Concern to: Oncogenehttps://doi.org/10.1038/s41388-021-01697-6, published online 25 March 2021 The Editors-in-Chief would like to alert the readers that concerns have been raised regarding some of the figures presented in this article [1]. Specifically: The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The DR5 abd H3 western blot images in Fig. 4A and F (top) appear to overlap; In Fig. 6B, the red channels of MSC-GFP A172-S and A172-R appear highly similar; In Fig. 6E, the representative panels from mouse bioluminescence images from two different time points (d3/A172-R/GFP and d7/A172-R/TRAIL) appear highly similar. The authors have provided the raw data pertaining to Figs. 4A, 4F and 6B and stated that the errors in the panels in question occurred during manuscript preparation inadvertently. The conclusions of these figures remain unchanged. However, the original images for Fig. 6E are no longer available. Readers are therefore advised to interpret these results with caution. All authors agree to this Editorial Expression of Concern. © Springer Nature Limited 2024.Publication Metadata only Neuropeptides affecting social behavior in mammals: oxytocin(Elsevier Inc., 2024) Zhou, Hong; Zhu, Rui; Xia, Yuqing; Zhang, Xinming; Wang, Zixu; Lorimer, George H.; Ghiladi, Reza A.; Wang, Jun; Bayram, Hasan; ; School of Medicine;Oxytocin (OXT), a neuropeptide consisting of only nine amino acids, is synthesized in the paraventricular and supraoptic nuclei of the hypothalamus. Although OXT is best known for its role in lactation and parturition, recent research has shown that it also has a significant impact on social behaviors in mammals. However, a comprehensive review of this topic is still lacking. In this paper, we systematically reviewed the effects of OXT on social behavior in mammals. These effects of OXT from the perspective of five key behavioral dimensions were summarized: parental behavior, anxiety, aggression, attachment, and empathy. To date, researchers have agreed that OXT plays a positive regulatory role in a wide range of social behaviors, but there have been controversially reported results. In this review, we have provided a detailed panorama of the role of OXT in social behavior and, for the first time, delved into the underlying regulatory mechanisms, which may help better understand the multifaceted role of OXT. Levels of OXT in previous human studies were also summarized to provide insights for diagnosis of mental disorders. © 2024 Elsevier Inc.Publication Metadata only The European Network for IgE-Mediated Autoimmunity and Autoallergy (ENIGMA) initiative(Nature Portfolio, 2024) Kolkhir, Pavel; Altrichter, Sabine; Badloe, Fariza Mishaal Saiema; Belasri, Hafsa; Charles, Nicolas; De Vriese, Shauni; Gutermuth, Jan; Huygen, Lisa; Krohn, Inge Kortekaas; Munoz, Melba; Monino-Romero, Sherezade; Reber, Laurent L.; Scheffel, Joerg; Steinert, Carolin; Xiang, Yi-Kui; Maurer, Marcus; Kocatürk Göncü, Özgür Emek; ; School of Medicine;[No abstract available]Publication Metadata only The forkhead transcription factor FOXJ1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation(Public Library Science, 2024) Rayamajhi, Dheeraj; Ege, Mert; Ukhanov, Kirill; Ringers, Christa; Zhang, Yiliu; Jung, Inyoung; D'Gama, Percival P.; Li, Summer Shijia; Cosacak, Mehmet Ilyas; Kizil, Caghan; Park, Hae-Chul; Martens, Jeffrey R.; Brody, Steven L.; Jurisch-Yaksi, Nathalie; Roy, Sudipto; Yakşi, Emre; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine;In vertebrates, olfactory receptors localize on multiple cilia elaborated on dendritic knobs of olfactory sensory neurons (OSNs). Although olfactory cilia dysfunction can cause anosmia, how their differentiation is programmed at the transcriptional level has remained largely unexplored. We discovered in zebrafish and mice that Foxj1, a forkhead domain-containing transcription factor traditionally linked with motile cilia biogenesis, is expressed in OSNs and required for olfactory epithelium (OE) formation. In keeping with the immotile nature of olfactory cilia, we observed that ciliary motility genes are repressed in zebrafish, mouse, and human OSNs. Strikingly, we also found that besides ciliogenesis, Foxj1 controls the differentiation of the OSNs themselves by regulating their cell type-specific gene expression, such as that of olfactory marker protein (omp) involved in odor-evoked signal transduction. In line with this, response to bile acids, odors detected by OMP-positive OSNs, was significantly diminished in foxj1 mutant zebrafish. Taken together, our findings establish how the canonical Foxj1-mediated motile ciliogenic transcriptional program has been repurposed for the biogenesis of immotile olfactory cilia, as well as for the development of the OSNs. Olfaction is mediated by ciliated sensory neurons, but how olfactory cilia and sensory neuron differentiation is regulated has remained obscure. This study of zebrafish and mice shows that the forkhead domain transcription factor Foxj1 is critical for olfactory cilia and sensory neuron differentiation.