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    A study of the factors affecting the duration of exclusive breastfeeding
    (Nobel İlaç, 2009) Vehid, Hayriye Ertem; Vehid, Suphi; Gökçay, Gülbin; Bulut, Ayşen; Department of Chemistry; Haciu, Durata; Teaching Faculty; Department of Chemistry; College of Sciences; N/A
    Objective: This study aims to identify factors affecting the duration of exclusive breastfeeding during the first 6 months of life. Material and Method: The study was Carded out oil two groups of women, a study group of 125 women who received breastfeeding counselling voluntarily between July 2002 and June 2003, and a control group of 125 women who did not receive any counselling. Hospital interventions during delivery, sociodemographic characteristics of the mother support of the father and family members, antenatal education of the mother, are the factors evaluated for the duration of exclusive breastfeeding. The analysis was performed using the Cox regression method and significant hazard ratio values were used for analysis The data evaluated in this study was approved by the Ethical Committee of The medical Faculty of İstanbul University (Nr. 21375). Results: At 6 months of age 57.6% of the infants from, the study group and 11.2% from the control group were exclusively breastfeeding When the two groups were evaluated together the leading factor affecting the duration of exclusive breastfeeding, was found to be antenatal education (p=0.036) Within the first 6 months of life, the risk of stopping breast feeding among mothers who did not receive antenatal education is 1.67 times higher than in those who had antenatal education. Conclusion: Our findings show that, the proportion of exclusive breastfeeding was significantly high In the study group. This difference became more significant among mothers who had antenatal education oil breast-feeding in conclusion, antenatal education and breast-feeding counselling seemed to be necessary for successful breast-feeding diving the first 6 months of life.
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    PublicationOpen Access
    A young male patient presented with dyspnea, cough, and lilateral pulmonary infiltrations: what is your siagnosis?
    (Aves, 2016) Department of Chemistry; İliaz, Sinem; Yurtsever, İsmail Ersin; Çağlayan, Benan Niku; Doctor; Department of Chemistry; College of Sciences; Koç University Hospital; 168584; 7129; N/A
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    Targeted delivery of lacosamide-conjugated gold nanoparticles into the brain in temporal lobe epilepsy in rats
    (Elsevier, 2020) Yılmaz, Canan Uğur; Emik, Serkan; Orhan, Nurcan; Arican, Nadir; Küçük, Mutlu; N/A; N/A; N/A; Department of Chemistry; N/A; N/A; N/A; Temizyürek, Arzu; Atış, Müge; Akcan, Uğur; Khodadust, Rouhollah; Gürses, Rabia Candan; Ahıshalı, Bülent; Kaya, Mehmet; Other; PhD Student; PhD Student; Other; Faculty Member; Faculty Member; Faculty Member; Department of Chemistry;  Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Graduate School of Health Sciences; College of Sciences; School of Medicine; School of Medicine; School of Medicine; 357912; 346431; N/A; N/A; 110149; 9509; 10486
    Temporal lobe epilepsy (TLE) is the most common form of epilepsy with focal seizures, and currently available drugs may fail to provide a thorough treatment of the patients. The present study demonstrates the utility of glucose-coated gold nanoparticles (GNPs) as selective carriers of an antiepileptic drug, lacosamide (LCM), in developing a strategy to cross the blood-brain barrier to overcome drug resistance. Intravenous administration of LCM-loaded GNPs to epileptic animals yielded significantly higher nanoparticle levels in the hippocampus compared to the nanoparticle administration to intact animals. The amplitude and frequency of EEG-waves in both ictal and interictal stages decreased significantly after LCM-GNP administration to animals with TLE, while a decrease in the number of seizures was also observed though statistically insignificant. In these animals, malondialdehyde was unaffected, and glutathione levels were lower in the hippocampus compared to sham. Ultrastructurally, LCM-GNPs were observed in the brain parenchyma after intravenous injection to animals with TLE. We conclude that glucose-coated GNPs can be efficient in transferring effective doses of LCM into the brain enabling elimination of the need to administer high doses of the drug, and hence, may represent a new approach in the treatment of drug-resistant TLE.