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Department: search.filters.department.Department of Computer EngineeringSubject: search.filters.subject.Clinical neurology

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    Associations between sleep characteristics and glycemic variability in youth with type 1 diabetes
    (Elsevier, 2023) 0000-0002-2614-0832; 0000-0003-3781-3892; 0000-0001-6312-6004; 0000-0002-8889-6811; 0000-0002-7855-1297; 0000-0003-3919-7763; 0000-0003-1633-9570; Boran, Perran; Baris, Hatice Ezgi; Us, Mahmut Caner; Aygun, Burcu; Haliloglu, BelmaBereket, Abdullah; N/A; N/A; N/A; N/A; Department of Computer Engineering; N/A; N/A; İpar, Necla; Gökçe, Tuğba; Can, Ecem; Eviz, Elif; İnan, Neslihan Gökmen; Mutlu, Rahime Gül Yeşiltepe; Hatun, Şükrü; Doctor; Doctor; Nurse; Researcher; Teaching Faculty; Faculty Member; Faculty Member; N/A; N/A; N/A; School of Medicine; College of Engineering; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 327618; 285581; 153511; 153504
    Objective: This study aimed to determine sleep characteristics and their associations with glycemic variability in youth with type 1 diabetes (T1D).Material and methods: This cross-sectional study conducted at two pediatric diabetes centers in Istanbul, Turkey, included 84 children with T1D (mean age 10.5 years). Sleep characteristics and glycemic variability were determined by actigraphy, DSM-5 Level 2-Sleep Disturbance Scale Short Form and continuous glucose monitoring. Circadian preference was evaluated by the Children's Chronotype Questionnaire. Sleep disturbances were assessed by the. The sleep quality was determined by actigraphyderived sleep measures. Results: Eighty-eight percent of participants had insufficient age-appropriate total sleep time (TST) (<9 h for 6-13-year-olds and <8 h for 14-17-year-olds). Chronotype was classified as intermediate in 50%, evening in 45.2%, and morning in 4.8%. A higher chronotype score indicating a stronger eveningness preference was associated with more time spent in hypoglycemia (f3= 0.433, p = 0.002). On nights when participants had lower sleep efficiency and longer sleep onset latency, they had significantly higher overnight glycemic variability (f3 = -0.343, p = 0.016, f3 = 0.129, p = 0.017, respectively). Prolonged nocturnal wake duration was significantly associated with more time spent in daytime hypoglycemia (f3 = 0.037, p = 0.046) and higher overnight glycemic variability (J index, f3 = 0.300, p = 0.015). The associations between TST and glycemic variability indices were not significant.Conclusions: Sleep quality rather than TST was significantly associated with glycemic variability in children with T1D. Eveningness preference might contribute to an increased risk of hypoglycemia. Addressing sleep patterns and chronotypes can be crucial in management plans for youth with T1D.& COPY; 2023 Elsevier B.V. All rights reserved.
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    Corrigendum to "Associations between sleep characteristics and glycemic variability in youth with type 1 diabetes" [Sleep Med. 109 (2023) 132-142]
    (Elsevier B.V., 2023) 0000-0002-2614-0832; 0000-0003-3781-3892; 0000-0001-6312-6004; 0000-0002-8889-6811; 0000-0002-7855-1297; 0000-0003-3919-7763; 0000-0003-1633-9570; Boran, Perran; Barış, Hatice Ezgi; Us, Mahmut Caner; Aygün, Burcu; Haliloğlu, Belma; Bereket, Abdullah; N/A; N/A; N/A; N/A; Department of Computer Engineering; N/A; N/A; İpar, Necla; Gökçe, Tuğba; Can, Ecem; Eviz, Elif; İnan, Neslihan Gökmen; Mutlu, Rahime Gül Yeşiltepe; Hatun, Şükrü; Doctor; Doctor; Nurse; Researcher; Teaching Faculty; Faculty Member; Faculty Member; N/A; N/A; N/A; School of Medicine; College of Engineering; School of Medicine; School of Medicine; Koç University Hospital; N/A; N/A; N/A; 327618; 285581; 153511; 153504
    [The authors regret < that there was an error in the prevalence of T1DM in the introduction section. The correct prevalence should be 0.75/1000 in Turkey>. The authors would like to apologise for any inconvenience caused. © 2023 Elsevier B.V.
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    Efficacy and tolerability of immediate switch from sodium channel blockers to Lacosamide
    (Academic Press Inc Elsevier Science, 2023) 0000-0002-3752-1825; 0000-0001-7718-4299; N/A; 0000-0002-7671-7097; N/A; Yilmaz, Melek Kandemir; Atmaca, Murat Mert; Guler, Selda Keskin; N/A; N/A; N/A; Department of Computer Engineering; N/A; Gürses, Rabia Candan; Çelebi, Özlem; Buluş, Eser; Duman Arda; Özgün, Orhan Talha; Faculty Member; Doctor; Doctor; Undergraduate Student; Undergraduate Student; School of Medicine; N/A; N/A; College of Engineering; School of Medicine; Koç University Hospital; 110149; N/A; N/A; N/A; N/A
    Lacosamide (LCM) is a new-generation anti-seizure medication approved for monotherapy and add-on therapy for focal-onset epilepsy. It has novel pharmacodynamics and favorable pharmacokinetic qualities with good clinical response. This study aims to evaluate the effectiveness and tolerability of LCM when used in the immediate switch from sodium channel blockers in patients with focal-onset and generalized-onset epilepsies. This retrospective, multicenter observational study was conducted with adult patients who received LCM as mono-or polytherapy through immediate switch with 6 to 52 months follow-up. The clinical data obtained during the follow-up period were analyzed to assess retention rate, seizure freedom, more than 50% seizure reduction, and adverse effects. A total of 32 patients (eight females, 24 males) with a median age of 49.75 (range, 23-86) years, median age at epilepsy onset of 32.58 (range, 0.5-85) years, and median epilepsy duration of 17.17 (range, 1-46) years were included in this study. Seizure frequency was between 1 and 90 in the past 6 months. Seven (21.9%) of the patients had structural brain lesions and 27 (84.4%) of the patients had EEG abnormalities. The adverse effects leading to switching were hyponatremia, rash, elevated liver enzymes, pain, and erectile dysfunction. At 14.34 (range, 6-52) months follow-up, 30 (93.75%) patients in total retained LCM, 20 (66.7%) of them were seizure-free, and 13 were on LCM monotherapy. Responder rate was 81.25%. Eight (25%) of the patients experienced adverse effects after the immediate switch. One patient with generalized-onset epi-lepsy needed to quit LCM due to an increase in seizures. Seizure frequency did not change in three patients in the focal-onset group. Immediate switch to LCM showed favorable outcomes with a signifi-cant reduction in seizure frequency, high retention rates, and tolerable adverse effect profiles in both focal-onset and generalized-onset seizures.& COPY; 2023 Elsevier Inc. All rights reserved.