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Publication Metadata only Increasing the packing density of assays in paper-based microfluidic devices(Aip Publishing, 2021) Becher, Elaina; Ghaderinezhad, Fariba; Özkan, Mehmed; Yetişen, Ali Kemal; N/A; Department of Mechanical Engineering; N/A; Department of Media and Visual Arts; Dabbagh, Sajjad Rahmani; Taşoğlu, Savaş; Havlucu, Hayati; Özcan, Oğuzhan; N/A; Faculty Member; PhD Student; Faculty Member; Department of Mechanical Engineering; Department of Media and Visual Arts; Graduate School of Sciences and Engineering; College of Engineering; Graduate School of Social Sciences and Humanities; College of Social Sciences and Humanities; N/A; 291971; N/A; 12532Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.