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Department: search.filters.department.Department of PsychologySubject: search.filters.subject.Cell biology

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Now showing 1 - 3 of 3
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    Interval timing: stopping the internal stopwatch by photostimulation
    (Cell Press, 2017) Department of Psychology; Balcı, Fuat; Faculty Member; Department of Psychology; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Social Sciences and Humanities; 51269
    Animals use estimates of time intervals to adaptively guide their anticipatory actions. New research on mice shows that photostimulation of the neural pathway that coordinates drinking behavior delays subsequent anticipatory responses by pausing/resetting the internal stopwatch.
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    The negative association between religiousness and children's altruism across the world
    (Cell Press, 2015) Decety, Jean; Cowel, Jason M.; Lee, Kang; Mahasneh, Randa; Malcolm-Smith, Susan; Zhou, Xinyue; Department of Psychology; Selçuk, Bilge; Faculty Member; Department of Psychology; College of Social Sciences and Humanities; 52913
    In our paper, we reported cross-cultural differences in how the religious environment of a child negatively impacted their sharing, their judgments of the actions of others, and how their parents evaluated them. An error in this article, our incorrect inclusion of country of origin as a covariate in many analyses, was pointed out in a correspondence from Shariff, Willard, Muthukrishna, Kramer, and Henrich (https://doi.org/10.1016/j.cub.2016.06.031). When we reanalyzed these data to correct this error, we found that country of origin, rather than religious affiliation, is the primary predictor of several of the outcomes. While our title finding that increased household religiousness predicts less sharing in children remains significant, we feel it necessary to explicitly correct the scientific record, and we are therefore retracting the article. We apologize to the scientific community for any inconvenience caused.
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    PublicationOpen Access
    The ventral hippocampus CA3 is critical in regulating timing uncertainty in temporal decision-making
    (Elsevier, 2021) Çavdaroğlu, Bilgehan; Riaz, Sadia; Shi, Yuqing; Ito, Rutsuko; Department of Psychology; Balcı, Fuat; Faculty Member; Department of Psychology; KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Social Sciences and Humanities; 51269
    Timing uncertainty is a critical component of temporal decision-making, as it determines the decision strategies that maximize reward rate. However, little is known about the biological substrates of timing uncertainty. In this study, we report that the CA3 subregion of the ventral hippocampus (vCA3), a relatively unexplored area in timing, is critical in regulating timing uncertainty that informs temporal decision making. Using a variant of the differential reinforcement of low rates of responding (DRL) task that incorporates differential levels of approach-avoidance conflict, rats were trained to wait a minimum of 6 s to earn a reward that was paired with varying durations of foot shock. Post-training chemogenetic inhibition of the vCA3 reduced timing uncertainty without affecting mean wait times, irrespective of the level of conflict experienced. Simulations based on the information-processing variant of scalar expectancy theory (SET) revealed that the vCA3 may be important in modulating decision threshold or switch closure latency variability. © 2021 The Author(s)The neural substrate of timing uncertainty, an inherent component of optimal temporal decision making, is not well known. Using a temporal decision-making task combined with chemogenetics, Çavdaroğlu et al. demonstrate that pyramidal cells in the CA3 subregion of the ventral hippocampus are important in modulating timing uncertainty.