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Publication Metadata only 18F-FDG PET/CT imaging in a patient with a rare diagnosis of sarcomatoid malignant peritoneal mesothelioina(Lippincott Williams & Wilkins, 2013) Tokmak, Handan; Demirkol, Onur M.; Kaban, Kerim; N/A; Mandel, Nil Molinas; Dilege, Şükrü; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 194197; 122573Malignant peritoneal mesothelioma is an uncommon but deadly disease arising from serosal surfaces of the peritoneum. Asbestos exposure is the most recognized risk factor. We report a case of diffuse, sarcomatoid malignant peritoneal mesothelioma who presented to the hospital with abdominal pain. The patient had an abdominal MRI scan as initial scanning which demonstrated nonspecific findings suspected of peritoneal carcinomatosis. The patient was admitted to our department for the metabolic characterization of the lesions with F-18-FDG PET/CT imaging and the diagnosis of the primary malignancy. F-18-FDG PET/CT imaging revealed diffusely increased metabolic activity throughout the peritoneum and the histopathological features were compatible with sarcomatoid malignant peritoneal mesothelioma.Publication Metadata only A nation-wide study determining psychosocial care skill perceptions of Turkish nurses working with cancer patients(Wiley, 2018) Yildirim, Nazmiye Kocaman; Inci, Figen; Hicdurmaz, Duygu; Fernandez, Ritin Santiago; Ozdemir, Sevgul; Ince, Aysegul; Yildirim, Yeter; N/A; Güner, Perihan; Faculty Member; School of Nursing; 101859N/APublication Metadata only A nation-wide study of Turkish oncology nurses' perceptions towards providing care for cancer patients(Wiley, 2018) Inci, Figen; Hicdurmaz, Duygu; Yildirim, Nazmiye Kocaman; Fernandez, Ritin Santiago; Ozdemir, Sevgul; Ince, Aysegul; Yildirim, Yeter; N/A; Güner, Perihan; Faculty Member; School of Nursing; 101859N/APublication Metadata only A platinum-blue complex exerts its cytotoxic activity via dna damage and induces apoptosis in cancer cells(Elsevier, 2016) Adiguzel, Z.; Ozalp-Yaman, S.; Celik, G.; Salem, S.; Cetin, Y. C.; Arda, N.; Acilan, C.; N/A; Önder, Tuğba Bağcı; Faculty Member; School of Medicine; 184359N/APublication Metadata only A primary extended cytoreductive surgery for ovarian cancer: total abdominal hysterectomy and bilateral salpingo-oophorectomy, total omentectomy, total peritonectomy, bilateral diaphragm stripping, cholecystectomy, total colectomy, splenectomy, bilateral pelvic-paraaortic lymphadenectomy, dissection of porta hepatis, liver metastasectomy, and bilateral cardiophrenic lymphadenectomy(Bmj Publishing Group, 2019) Giray, B.; Kumcular, T.; Arvas, M.; N/A; N/A; N/A; N/A; Taşkıran, Çağatay; Vatansever, Doğan; Mısırlıoğlu, Selim; Balık, Emre; Faculty Member; Faculty Member; Faculty Member; N/A; Faculty Member; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; 134190; 193687; N/A; N/A; 18758Introduction/Background: Ovarian cancer is the leading cause of death among gynecological malignancies. Primary cytoreduction for ovarian cancer is associated with significantly improved survival. We aimed to present a primary extended cytoreduction performed in this video. Methodology: A 37 years-old woman was admitted with abdominal swelling and pelvic pain. Pelvic examination revealed out ascites and bilateral adnexal masses. MRI showed 11-cm right adnexal mass, 7-cm left adnexal mass, omental cakes, disseminated peritoneal implants, liver metastases, and enlarged lymph nodes in the right obturator fossa. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, total omentectomy, total peritonectomy, bilateral diaphragmatic stripping, total colectomy, splenectomy, bilateral pelvic-paraaortic lymphadenectomy, cholecystectomy, dissection of the porta hepatis, liver metastasectomy, and transabdominal cardiophrenic lymph node dissection were performed as a part of maximal primarily cytoreduction. Results: We did not encounter any grade 3 or 4 adverse event in post-operative period. Conclusion: Primary cytoreduction for ovarian cancer with no residual disease is a major impact on survival. The management of this condition should be performed with expert multidisciplinary teams in gynecological oncology.Publication Metadata only Achieving global standards in pediatric oncology nursing: pediatric oncology clinical profile of Turkey(Elsevier, 2022) Yılmaz, P.; N/A; Semerci, Remziye; Faculty Member; School of Nursing; 216754Background: Nurses have an important role in improving the quality of care for pediatric oncology patients. In this context, it is important for nurses to apply care within the framework of international standards. This study aimed to examine the status of reaching the global nursing standards determined by SIOP in pediatric oncology nursing in Turkey. Methods: The descriptive study was conducted with nurse managers in 62 pediatric oncology centers in Turkey between February and May 2022. The ‘Information Form' and six global nursing standards created by the SIOP Nurse Working Group were transformed into a form by the researchers. were used for data collection. Participants were asked to respond as ‘Available' or ‘Not Available' in the clinics of these standards. The data were obtained online by reaching the nurse managers in cooperation with the Oncology Nursing Association and the Turkish Pediatric Oncology Group. Results: It was determined the mean number of beds in the clinics was 21.73±11.28, the number of nurses working in the clinics was 14.00±6.96, there were no specialist nurses in 68.2% of the clinics, and specialist nurses were included in the rotations in 18.2% of the clinics. It was found that 27.3% of the clinics met the nurse standard for five patients, I72.7% of the clinics applied for an orientation program, 77.3% of clinics applied at least 10 hours of continuous training program annually. 77.3% of clinics accepted nurses as part of a multidisciplinary team, 63.6% had all resources available for safe pediatric oncology care, 63.6% adopted evidence-based pediatric oncology nursing policies and procedures, and 36.4% were financially supported in research conducted to improve nursing policies and procedures. Conclusions: It was determined that it was insufficient to meet the standards developed for pediatric oncology nurses in pediatric oncology clinics in Turkey. It was determined that the number of specialist nurses working in the clinics is low, the number of patients a nurse takes care of is high, and the nurses are not financially supported enough in their research to develop nursing policies and procedures. It is important that managers and associations have action plans that require pediatric oncology nurses to reach global standards.Publication Metadata only Acinar cell induced autolysis is a frequent occurrence in Cytolyt-fixed pancreatic fine needle aspiration specimens: an analysis of 157 cytology samples(Wiley, 2021) Alwelaie, Yazeed; Point du Jour, Kimberly S.; Pandya, Sonal; Goodman, Abigail L.; Centeno, Barbara A.; Reid, Michelle D.; N/A; Adsay, Nazmi Volkan; Faculty Member; School of Medicine; Koc University Hospital; 286248Background Although 10% formalin is a standard preservative in pancreatic FNAs, the effect of CytoLyt on pancreatic tissue preservation has not been systematically explored. Methods Smears and cell blocks from CytoLyt-fixed (CF-CBs) and formalin-fixed (FF-CBs) pancreatic FNAs were blindly reviewed without knowledge of the fixative used, and the presence of tissue/tumor autolysis was noted. Controls included FF-CBs from pancreatic FNAs, CF-CBs from nonpancreatic FNAs, and 4 pancreatic FNAs with matched CF-CBs and FF-CBs. Results We found that 62 of 85 (73%) pancreatic FNAs with CF-CBs showed significant autolysis, which was most pronounced in acinar cells and/or tumor cells with benign acinar cells in the background, compared with 2 of 46 (4%) FF-CBs (P < .0001) and 3 of 26 (12%) CF-CBs from nonpancreatic FNAs (73% vs 12%; P < .0001). Of the 4 pancreatic FNAs with matched CF-CBs and FF-CBs, all 4 CF-CBs showed marked autolysis versus none of the matched FF-CBs. Of the 23 (27%) pancreatic FNAs with CF-CBs that did not show autolysis, 10 had no acinar cells, and 7 had only minute tissue fragments on CB. Conclusion While CytoLyt is a useful fixative for nonpancreatic FNAs it is a suboptimal fixative for pancreatic FNAs and is associated with tissue/tumor autolysis in the majority of cases, influencing morphologic evaluation, and potentially immunocytochemical staining. Autolysis appears to be due to acinar enzymes whose effect is likely interrupted/inhibited by formalin fixation. Cytopathologists and cytotechnologists should be mindful of this pitfall and should avoid using CytoLyt as a fixative for pancreatic FNAs.Publication Open Access Activated leukocyte cell adhesion molecule regulates the interaction between pancreatic cancer cells and stellate cells(Spandidos Publications, 2016) Zhang, Wei-Wei; Zhan, Shu-Hui; Geng, Chang-Xin; Sun, Xin; Kleeff, Joerg; Xie, Xiang-Jun; N/A; Erkan, Murat Mert; Faculty Member; School of Medicine; 214689Activated leukocyte cell adhesion molecule (ALCAM/CD166) is a transmembrane glycoprotein that is involved in tumor progression and metastasis. In the present study, the expression and functional role of ALCAM in pancreatic cancer cells and pancreatic stellate cells (PSCs) was investigated. Tissue specimens were obtained from patients with pancreatic ductal adenocarcinoma (n=56) or chronic pancreatitis (CP; n=10), who underwent pancreatic resection, and from normal pancreatic tissue samples (n=10). Immunohistochemistry was used to analyze the localization and expression of ALCAM in pancreatic tissues. Subsequently, reverse transcription-quantitative polymerase chain reaction and immunoblotting were applied to assess the expression of ALCAM in pancreatic cancer Panc-1 and T3M4 cells, as well as in PSCs. An enzyme-linked immunosorbent assay was used to measure ALCAM levels in cell culture medium stimulated by hypoxia, tumor necrosis factor (TNF)- and transforming growth factor-. Silencing of ALCAM was performed using ALCAM small interfering (si)RNA and immunocytochemistry was used to analyze the inhibition efficiency. An invasion assay and a cell interaction assay were performed to assess the invasive ability and co-cultured adhesive potential of Panc-1 and T3M4 cells, as well as PSCs. Histologically, ALCAM expression was generally weak or absent in pancreatic cancer cells, but was markedly upregulated in PSCs in pancreatic cancer tissues. ALCAM was highly expressed in PSCs from CP tissues and PSCs surrounding pancreatic intraepithelial neoplasias, as well as in pancreatic cancer cells. ALCAM mRNA was highly expressed in PSCs, with a low to moderate expression in T3M4 and Panc-1 cells. Similar to the mRNA expression, immunoblotting demonstrated that ALCAM protein levels were high in PSCs and T3M4 cells, but low in Panc-1 cells. The expression of TNF- increased, while hypoxia decreased the secretion of ALCAM in pancreatic cancer Panc-1 and T3M4 cells, and also in PSCs. Silencing of ALCAM by siRNA revealed no significant alteration in the invasion of pancreatic cancer cells, however, it inhibited the invasive ability of PSCs, and decreased the interaction between Panc-1 cells and PSCs. In conclusion, ALCAM is upregulated in PSCs of pancreatic cancer tissues, suggesting a potential role of ALCAM in regulating pancreatic cancer cell-PSC interactions.Publication Metadata only Adjuvant chemoradiotherapy after D2 resection in gastric cancer: a single-center observational study(Springer, 2015) Saglam, Esra Kaytan; Yucel, Serap; Saglam, Sezer; Asoglu, Oktar; Yamaner, Sumer; Oral, Ethem N.; Kizir, Ahmet; Kapran, Yersu; Sakar, Burak; Akyuz, Ali; Gulluoglu, Mine; N/A; Balık, Emre; Buğra, Dursun; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 18758; 1758Previous studies demonstrated survival benefits in association with the addition of chemoradiotherapy after surgery in gastric cancer. This study aimed to examine the efficacy in terms of loco-regional control and survival and safety of 5-FU-based adjuvant chemoradiotherapy after D2 curative surgery. This study included 228 patients (81 female, 147 male) treated for gastric cancer with curative surgery plus adjuvant chemoradiotherapy. Majority of the patients underwent at least D2 lymph node resection. Median three cycles of fluorouracil chemotherapy were administered, and 45-Gy radiotherapy was delivered at 1.8 Gy/fraction concomitantly during the second cycle of chemotherapy. Local control, regional control, distant metastasis and overall survival rates were estimated. The median age of the patients was 54 years (range 25-74 years). The most common grade III toxicities were nausea (10 %) and neutropenia (9 %). During radiotherapy, grade IV local skin reaction occurred in one patient. Median duration of follow-up was 47 months. Local, regional and distant recurrence developed in 9 (4 %), 41 (18 %) and 45 (20 %) patients, respectively. Overall 5-year survival rate was 57.2 %, and disease-free 5-year survival rate was 53.8 %. Multivariate analysis identified less than 15 lymph node involvement as an independent predictor of better survival (p < 0.001). Concomitant 5-FU-based chemoradiotherapy seems to be an effective and tolerable adjuvant regimen on local control and survival in curatively resected node-positive stomach cancer, particularly when combined with D2 resection.Publication Open Access Adjuvant chemotherapy for gastric cancer in elderly patients has same benefits as in younger patients(Medknow Publications, 2018) Karaca, Mustafa; Tural, Deniz; Koçoğlu, Hakan; Bilgetekin, İrem; Özet, Ahmet; N/A; Selçukbiricik, Fatih; Faculty Member; School of MedicineObjective: The age-adjusted mortality rate due to gastric cancer was reported to increase with age. This study aims to investigate the results of adjuvant chemotherapy in patients aged 65 years or older comparing with younger patients and focusing on its impact on survival. Materials and Methods: A total of 406 patients with nonmetastatic gastric cancer that consisted of 283 patients younger than 65 years (range: 23-64 years) and 123 patients 65 years of age or older (range: 65-75 years) were retrospectively evaluated. Categorical and continuous variables were summarized using the descriptive statistics and compared with Chi-square and Mann-Whitney U-tests, respectively. Cancer-specific survival rates were estimated by the Kaplan-Meier method. Results: Median age at diagnosis was 58 years (range: 23-75 years). There was no significant difference in gender, tumor localization in the stomach (cardia/noncardia), tumor histology, perineural invasion, lymphovascular invasion, histopathological characteristics of the tumor, and tumor stage between groups. No significant difference was detected in survival between groups. The median survivals were 20.8 months (range: 17-24.6) in patients younger than 65 years and 19.5 months (range: 14.8-24.1) in patients 65 years of age or older (P = 0.9). Conclusions: We showed that adjuvant chemotherapy in elderly patients with gastric cancer has same effectiveness as nonelderly patients. However, further well-designated prospective studies are needed to confirm these findings.