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Publication Metadata only A comparison of the survival and implantation rates of blastocysts that were vitrified on postfertilization day five, six and seven(Taylor & Francis Ltd, 2019) Berrin, Avci; Isil, Kasapoglu; Goktan, Kuspinar; Seda, Saribal; Gurkan, Uncu; N/A; Ata, Mustafa Barış; Faculty Member; School of Medicine; 182910The goal of this retrospective cohort study was to compare survival, implantation, clinical and ongoing pregnancy rates between blastocysts that were vitrified on post-fertilization days 5, 6 and 7. Before vitrification, blastocysts were evaluated in terms of morphology and blastocyst expansion, inner cell mass and trophectoderm quality. They were thawed and transfered in a subsequent artificial cycle. Embryo implantation rates were 39%, 25% and 25% for blastocysts that were vitrified on days 5, 6, and 7, respectively (p = 0.006). Clinical and ongoing pregnancy rates were 19%, 12%, 13% (p = 0.100) and 9%, 7%, 12% (p = 0.99) for days 5, 6 and 7 blastocysts, respectively. Day 5 blastocysts had significantly higher full-collapsing score after assisted-hatching compared to days 6 and 7 blastocysts (p = 0.014). As blastocyst quality increased, implantation and clinical pregnancy rates increased in all groups and both parameters were statistically significantly higher on day 5 blastocysts than on days 6 or 7 (p = 0.001). It was clearly found that good quality blastocysts obtained on day 5 have higher implantation and clinical pregnancy rates than 6th and 7th day cryopreserved embryos. There were no statistically significant differences between the cryopreserved embryos on days 6 and 7 regarding the implantation, clinic and ongoing pregnancy rates.Publication Metadata only A drop in serum progesterone(p4) levels between 5th and 7th days of triggering ovulation is associated with lower ongoing pregnancy rate(opr) in intrauterine insemination cycles(Oxford Univ Press, 2022) Orhan, N.; Gunalp, G. S.; Yarali, H.; Mumusoglu, S.; N/A; Bozdağ, Gürkan; Faculty Member; School of Medicine; 55090N/APublication Metadata only A novel flexible progestin primed ovarian stimulation protocol: comparison of pregnancy outcomes with the flexible GnRH antagonist protocol in an oocyte donation program(Elsevier, 2019) Eraslan, Alper; Angun, Berk; N/A; Yıldız, Şule; Türkgeldi, Engin; Ata, Mustafa Barış; Faculty Member; Faculty Member; Faculty Member; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; Koç University Hospital; N/A; 134205; 329649; 232576Publication Metadata only Activin-a promotes luteal regression by down-regulating the expression of steroidogenic enzymes and up-regulating BMP-6 and activin-A subunit in human luteal granulosa cells(Elsevier, 2015) Güzel, Yılmaz; Seyhan Ata, Ayşe; Balaban, Başak; N/A; Akın, Nazlı; Bildik, Gamze; Urman, Cumhur Bülent; Öktem, Özgür; Master Student; Master Student Faculty Member; Faculty Member; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; 12147; 102627Publication Metadata only Agonist trigger is associated with defective progesterone production and decreased LH receptor and VEGF expression in luteal granulosa cells that are partially reversed by hCG(Oxford University Press (OUP), 2017) Seyhan, A.; Balaban, B.; N/A; N/A; N/A; N/A; Akın, Nazlı; Bildik, Gamze; Urman, Cumhur Bülent; Öktem, Özgür; Master Student; Teaching Faculty; Faculty Member; Faculty Member; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; 12147; 102627N/APublication Metadata only Altered expression of Notch signaling, Tlr receptors, and surfactant protein expression after prostaglandin inhibition may be associated with the delayed labor in LPS-induced mice(Springer/Plenum Publishers, 2022) Avcı, Sema; Kuşçu, Nilay; Durkut, Begüm; Kılınç, Leyla; Üstünel, İsmail; N/A; Özenci, Çiler Çelik; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 127168Purpose This study aims to investigate whether indomethacin (IND) delays preterm birth by regulating the Notch pathway, Tlr receptors, and Sp-A in the placenta in lipopolysaccharide (LPS)-induced preterm labor (PTL) model. Methods CD-1 mice were distributed to the pregnant control (PC), Sham, PBS, IND (2 mg/kg; i.p.), LPS (25 mu g/100 mu l; intrauterine), and LPS + IND groups. The injections were performed on day 14.5 of pregnancy. Placentae were collected on day 15.5 of pregnancy, and immunohistochemical analyzes were performed. Differences in staining intensities between the Cox-1, Notch-1 (N1), Dll-1, Jagged-2 (Jag-2), Tlr-2, and Tlr-4 proteins were compared. Results Preterm labor rates were 100% and 66% (preterm delivery delayed 5 h) in the LPS and LPS + IND groups, respectively. In LPS-treated mice, a general morphological deterioration was observed in the placenta. Total placental mid-sagittal measurement was significantly reduced in the LPS-treated group, while it was similar to the PC group in the LPS + IND group. Cox-1 expression in the LZ increased, and Sp-A expression decreased after LPS injection, and IND administration diminished this increase. N1 expression increased in the labyrinth zone (LZ) and the junctional zone (JZ). Dll-1 and Jag-2 expression increased in the JZ after LPS injection (p < 0.0001). IND administration diminished Tlr-2 expression in the LZ and Tlr-4 expression in the JZ after LPS injection. Conclusion In conclusion, PG (prostaglandin) inhibition may alter Notch signaling, Tlr, and Sp-A protein expression and may be associated with delayed labor in LPS-induced mice.Publication Open Access An example from the rural areas of Turkey: women breast cancer risk levels and application and knowledge regarding early diagnosis-scan of breast cancer(Aves, 2017) Türk, Rukiye; Terzioglu, Füsun; Taşkın, Lale; N/A; Eroğlu, Kafiye; Faculty Member; School of Nursing; 6061Objective: This research has been conducted for the purpose of determining the cancer risk levels of women living in a small village of in Saraycık village of Ankara and their knowledge and application of breast cancer early diagnose-scan methods. Materials and Methods: 317 women were taken as examples for the study. Data were collected by giving survey forms to women and conducting face-to-face interviews. In determining breast cancer risk, ''the form to determine the breast cancer risk'' has been used. For breast cancer informational questions, one point has been given for each correct answer. In evaluating the data, number, percentage calculations, average and standard deviation, Mann-Whitney U (MU), Kruskal-Wallis (KW), One-way analysis of variance (F) independent sample T (t) tests have been used. Results: It has been found that breast cancer risk is low, the knowledge level about cancer early recognition methods are medium among the women. It has been determined that 74.4% women didn't perform breast self-examination. 89.6% of women don't have mammography taken and 88.6% don't have their breast examined by health personnel. Conclusion: In our study, it has been found that the risk levels of women are low, their knowledge about early diagnosis and cure are at a medium level and their use of these methods are inadequate. For this reason, we suggest that responsibility of healthcare professionals have to be increased in determining breast cancer risk among women and education and advisory services for this subject to be offered.Publication Metadata only Anogenital distance in newborn infants conceived by assisted reproduction and natural conception(Oxford Univ Press, 2020) Ercin, S.; Ertas, S.; Dundar, O.; N/A; Öktem, Özgür; Yakın, Kayhan; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 102627; 106822N/APublication Metadata only Antimetabolite cancer drug gemcitabine selectively impacts preantral and antral follicle cohorts in the ovary as evidenced by quantitatively histomorphometric, hormonal and cell viability markers(Oxford Univ Press, 2014) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Kılıç, Yağmur; Şahin, Gizem Nur; Karanfil, Işıl; Eryılmaz, Baldan; Yılmaz, Pelinsu; Özkanbaş, Necmettin Can; Öktem, Özgür; Undergraduate Student; PhD Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; School of Medicine; Graduate School of Health Sciences; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; N/A; N/A; N/A; N/A; 102627N/APublication Metadata only Antral follicles developing from primary and preantral follicles in culture: are we getting closer to obtaining mature oocytes from in vitro grown follicles in human?(Oxford Univ Press, 2014) Sahin, G.; N/A; N/A; Urman, Cumhur Bülent; Öktem, Özgür; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 12147; 102627N/A