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Publication Metadata only “Doing What Matters in Times of Stress” to decrease psychological distress during Covid-19: a rammed controlled pilot trial(Wolters Kluwer Medknow Publications, 2022) Uygun, Ersin; Karaoğlan Kahiloğulları, Akfer; Department of Psychology; Department of Psychology; N/A; Acartürk, Ceren; Kurt, Gülşah; İlkkurşun, Zeynep; Faculty Member; Teaching Faculty; Master Student; Department of Psychology; College of Social Sciences and Humanities; College of Social Sciences and Humanities; Graduate School of Social Sciences and Humanities; 39271; 368619; N/ADespite the increasing psychological distress during Covid-19, utilisation of face-to-face psychological interventions decreased profoundly. The aim of this study involving two parallel, two-armed pilot randomised controlled trials was to examine the effectiveness of a guided self-help intervention "Doing What Matters in Times of Stress" (DWM) in decreasing psychological distress in Turkish and Syrian participants. Seventy-four Turkish nationals and 50 Syrian refugee adults with psychological distress were randomly allocated to a DWM group or wait-list control group. The primary outcome measure was the Patient Health Questionnaire 9 postintervention. Secondary outcome measures were the Generalised Anxiety Disorder Scale, posttraumatic stress disorder (PTSD) Checklist for DSM-5, Generalized Self-Efficacy Scale and Acceptance and Action Questionnaire-II postintervention. Although this study was not powered to detect a significant effect for DWM postassessment between DWM and the control group, results showed a significant improvement in depression symptoms among Turkish participants in the DWM group (d = 0.46) and in PTSD symptoms among Syrian participants in the DWM group (d = 0.67) from pre- to postintervention assessment. These results indicate the potential of DWM to decrease mental health problems during the pandemic and importance of a fully powered, definitive controlled trial to examine its effectiveness both for the host community and refugees to reduce psychological distress during Covid-19.Publication Metadata only A case-control candidate gene study on base excision repair mechanism (BER) as a novel therapeutic target in bipolar disorder(Wiley, 2022) Ozerdem, Aysegul; Veldic, Marin; Singh, Balwinder; Frye, Mark; Schulze, Thomas; Biernacka, Joanna; Winham, Stacey J.; N/A; Ceylan, Deniz; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; 137755N/APublication Metadata only A correlation network analysis of dissociative experiences(Routledge Journals, Taylor & Francis Ltd, 2019) Schimmenti, Adriano; N/A; Şar, Vedat; Faculty Member; School of Medicine; 8542The interrelationships between the symptom domains of dissociation, such as the loss of continuity in subjective experience, the inability to access personal information, and the distortions about the perception of self and the environment, need to be better understood. In the current study, 2274 adults from Italy completed the Dissociative Experiences Scale-II (DES-II), and their responses were examined within a correlation network analysis framework. Fifteen dissociative experiences showed the strongest associations with the other dissociative experiences included in the measure, and they were selected for further analysis. A partial correlation network was calculated to reveal the associations between such experiences, and a community detection analysis was used to explore whether they formed distinct clusters in the network. Subsequently, a Bayesian network was estimated to examine the direction of the associations among the dissociative experiences, and a directed acyclic graph (DAG) was generated to estimate a potentially causal model of their relationships. The community detection analysis revealed three clusters of experiences that were conceptualized in terms of trance, experiential disconnectedness, and segregated behaviors. Dissociative amnesia was a common denominator of all the three clusters. The analysis of the DAG further suggested that dissociation can be conceptualized as a network in which dissociative experiences are layered into groups of symptoms that interact among them. Cognizance of the configuration and interactions among the dissociative domains and their related symptoms may be critical for better understanding the internal logic behind the dissociative processes and for addressing them effectively in clinical practice.Publication Metadata only A meta-analysis of anxiety disorder comorbidity in pediatric bipolar disorder(Elsevier Science Inc, 2016) Taşkıran, Ali Sarper; Eser, Hale Yapıcı; Mutluer, Tuba; Kılıç, Özge; Özcan, Aslıhan; Necef, Işıl; Yalçınay-İnan, Merve; Öngür, Dost; Other; Faculty Member; Faculty Member; Doctor; Other; Doctor; Doctor; N/A; School of Medicine; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A College of Engineering; School of Medicine; School of Medicine; N/A; N/A; School of Medicine; N/A; N/A; Koç University Hospital; 195168; 134359; 305311; N/A; N/A; N/A; N/A; N/AObjectives: AD are among the most prevalent comorbid conditions in pediatric bipolar disorder (PBD). There are conflicting results in the literature regarding prevalence of AD subtypes, and significant discrepancy with PBD course of illness (episodic or chronic) or diagnostic criteria (narrow or broad). Our aim in conducting meta-analysis is to investigate the prevalence of subtypes of comorbid anxiety disorders and its relations with the onset (childhood or adolescent) and course (episodic or chronic) of PBD. Methods: We have conducted a systematic research of Pubmed by using “bipolar disorder, affective psychosis, generalized anxiety disorder, panic, social phobia, obsessive compulsive disorder and anxiety disorder” as keywords to search in title/abstract until September 2015. Among 3202 articles, a total of 430 abstracts were found to be related; 82 were conducted in pediatric population, which were read in full text by at least two authors and data was extracted for outcome measures. Articles that include the data from the same population sample were excluded. Data was analyzed with random effects model using R statistical program package. Results: Data from 33 studies were included in the final analysis. The prevalence of any AD in PBD was 44 percent (95% CI 0.38–0.50), prevalence of AD subtypes were GAD 25 percent (95% CI 0.18–0.36); Separation Anxiety Disorder (SAD) 22 percent (95% CI 0.14–0.33); OCD 17 percent (95% CI 0.11–0.23); Social Phobia (SP) 15 percent (95% CI 0.08–0.27); Panic Disorder (PD) 10 percent (95% CI 0.05–0.19). When only episodic PBD were concerned, prevalence rates differed, with any AD 38 percent (95% CI 0.28–0.48); GAD 19 percent (95% CI 0.08–0.41); SAD 21 percent (95% CI 0.10–0.40); OCD 11 percent (95% CI 0.03–0.29); SP 11 percent (95% CI 0.04–0.27); PD 9 percent (95% CI 0.03–0.23). Prevalence of any AD (34% (95% CI 0.23-0.48), GAD and SAD were found as lower and OCD, SP and PD were slightly higher in adolescent onset compared to childhood onset PBD. Conclusions: Youth with BD are at increased risk of AD; nearly one in two has an AD. GAD and SAD are among the most prevalent comorbidities. AD are seen less with episodic and adolescent onset PBD. AD should be carefully investigated alongside the mood symptoms in PBD, as comorbidity may change course, treatment and subtyping of the disorder.Publication Metadata only A postgraduate training program for early career psychiatrists serving patients with bipolar disorder(Wiley, 2022) Ceylan, Deniz; Yorguner, Nese; Tan, Devran; Altinbas, Kursat; Cakir, Sibel; N/A; Ceylan, Deniz; Faculty Member; School of Medicine; 137755N/APublication Metadata only A revised and expanded version of the Turkish childhood trauma questionnaire (CTQ-33): overprotection-overcontrol as additional factor(Routledge Journals, Taylor & Francis Ltd, 2021) Türk-Kurtça, Tuğba; N/A; N/A; N/A; N/A; Şar, Vedat; Necef, Işıl; Mutluer, Tuba; Fatih, Parmis; Faculty Member; Doctor; Faculty Member; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 8542; N/A; 305311; N/AThis study was concerned with a culture-sensitive revision of the Turkish version of the Childhood Trauma Questionnaire (CTQ-28) and expansion of the instrument through integration of a dimension assessing overprotection - overcontrol (OP-OC). Participants (n = 783) were 37 dissociative and 78 non-dissociative and non-psychotic psychiatric outpatients, and 668 non-clinical people. They completed the revised and expanded version of the CTQ, Dissociative Experiences Scale, Beck Depression Scale, and Relationship Scales Questionnaire. A test-retest assessment was conducted on 25 non-clinical individuals. Among twenty-one alternative and the twenty-five original statements, the items of subsections were selected by correlations between item and item deleted total scores for each subset of original and alternative statements. The 33-item final version (CTQ-33) included five statements for each subsection including OP-OC and three denial items. The principal component analysis on items of the CTQ-33 with a varimax rotation yielded six factors including OP-OC. The inner consistency and the test-retest reliability were good. OP-OC correlated particularly with emotional abuse and neglect, and other types of trauma. There were significant correlations between CTQ-33 and depression, dissociation, and fearful attachment scores. The CTQ-33 differentiated psychiatric from non-clinical groups. The Turkish CTQ-33 is a reliable and valid instrument. OP-OC by caregivers may be as traumatic as other types of childhood adversities. Cross-cultural research would illuminate the significance of OP-OC beyond Turkish culture. The possibility of intergenerational transmission of trauma through OP-OC by fearful parents in and after times of cultural upheaval and political oppression should be considered for future research.Publication Metadata only A study on the adaptation of the HIV/AIDS-related stigma scale into Turkish(Wiley, 2022) Bahar, Zuhal; Cal, Ayse; Cavusoglu, Figen; Deveci, Aydin; Badur, Selim; Bahar, Ismail Hakki; Beşer, Ayşe; Faculty Member; School of Nursing; 143490Purpose This study aims to test the validity and reliability of the Turkish version of the HIV/AIDS-related Stigma Scale. Design and Methods The study has a methodological design. The sample included a total of 428 participants. of the participants, 198 were HIV/AIDS patients, 230 were HIV-negative individuals. The data were analyzed using the Exploratory and Confirmatory Factor Analysis. Findings The Turkish version of the HIV/AIDS-related Stigma Scale was found to be valid and reliable for the Turkish society. Cronbach's alpha was 0.93 for the community perspectives subscale and 0.89 for the patient perspectives subscale, and all the model fit indices were acceptable. Practice Implications The level of stigmatization revealed by the scale helps gain an insight into the community and patient perspectives on HIV/AIDS.Publication Metadata only Abnormal high-energy phosphate molecule metabolism during regional brain activation in patients with bipolar disorder(Nature Publishing Group (NPG), 2015) Yuksel, C.; Du, F.; Ravichandran, C.; Goldbach, J. R.; Thida, T.; Lin, P.; Gelda, J.; O'Connor, L.; Sehovic, S.; Gruber, S.; Ongur, D.; Cohen, B. M.; Department of Psychology; Dora, Begüm; PhD Student; Department of Psychology; College of Social Sciences and Humanities; N/AConverging evidence suggests bioenergetic abnormalities in bipolar disorder (BD). In the brain, phosphocreatine (PCr) acts a reservoir of high-energy phosphate (HEP) bonds, and creatine kinases (CK) catalyze the transfer of HEP from adenosine triphosphate (ATP) to PCr and from PCr back to ATP, at times of increased need. This study examined the activity of this mechanism in BD by measuring the levels of HEP molecules during a stimulus paradigm that increased local energy demand. Twenty-three patients diagnosed with BD-I and 22 healthy controls (HC) were included. Levels of phosphorus metabolites were measured at baseline and during visual stimulation in the occipital lobe using P-31 magnetic resonance spectroscopy at 4T. Changes in metabolite levels showed different patterns between the groups. During stimulation, HC had significant reductions in PCr but not in ATP, as expected. In contrast, BD patients had significant reductions in ATP but not in PCr. In addition, PCr/ATP ratio was lower at baseline in patients, and there was a higher change in this measure during stimulation. This pattern suggests a disease-related failure to replenish ATP from PCr through CK enzyme catalysis during tissue activation. Further studies measuring the CK flux in BD are required to confirm and extend this finding.Publication Metadata only Alterations in expressions of DNA base excision repair (BER) genes in unipolar and bipolar depression(N/A, 2022) Yılmaz, Selda; Akan, Pınar; Özerdem, Ayşegül; N/A; Ceylan, Deniz; Baysal, Kemal; Faculty Member; Faculty Member; School of Medicine; School of Medicine; 137755; 119184N/APublication Metadata only An examination of the mediating role of maladaptive emotion regulation strategies in the complex relationship between interpersonal needs and suicidal behavior(Frontiers Media Sa, 2024) Bakhshesh-Boroujeni, Michael; Farajpour-Niri, Sepideh; Hekmati, Issa; Asgarabad, Mojtaba Habibi; Department of Psychology; Eskin, Mehmet; Department of Psychology; Graduate School of Social Sciences and Humanities; College of Social Sciences and HumanitiesBackground: Studies have shown that psychological factors, notably interpersonal needs and emotion regulation, play a significant role in suicidal behavior. Interpersonal needs are significant contextual components that affect emotion regulation and contribute to a wide range of dysfunctional behaviors, such as suicidal behavior. It has been postulated that emotion regulation mediates the associations between proximal and distal risk factors of suicidal behavior. Method: The sample consisted of 340 community-dwelling individuals (62.5% women;SD = 0.48) with an age range of 18 through 55 (M = 30.23;SD = 8.54) who completed the interpersonal needs questionnaire, the suicide behaviors questionnaire-revised, and the cognitive emotion regulation questionnaire. The Structural Equation Modeling (SEM) approach was utilized to evaluate a mediation model. Results: The findings indicate that interpersonal needs (i.e., perceived burdensomeness r = .55, p <.01 and thwarted belongingness r = .25, p <.01) and putatively maladaptive cognitive emotion regulation strategies (i.e., self-blame;r = .38, p <.01, catastrophizing;r = .55, p <.01, rumination;r = .40, p <.01, and other blame;r = .44, p <.01) have strong associations with suicidal behavior, and these strategies have a mediating effect on the association between interpersonal needs and suicidal behavior. Conclusions: Our findings show that contextual-interpersonal needs, which underpin suicidal behavior, are significantly influenced by maladaptive emotional processes. Thus, therapeutic outcomes might be enhanced by focusing on the content of the associated cognitions and trying to reduce maladaptive regulatory processes like rumination and catastrophization.